[Multiple-modality treatment of patients with psoriatic arthritis in the early stages of the disease]. / Kompleksne likuvannia khvorykh na psoriatychnyi artryt na rannikh stadiiakh zakhvoriuvannia.

Psoriatic arthritis is encountered in 7 to 44 percent of psoriatic cases. In managing the condition there arise certain difficulties related to our having no clear idea of the genesis of structural-and-functional changes in the locomotor system as well as in the blending of cutaneous and articular lesions. The study is based on the examination and treatment of 63 patients whose age ranged between 25 to 60 years. Instituted in the patients was a multimodality therapy with medicamentous, physiotherapeutic, and orthopedic treatments having been administered. Persistent lesion of the paraarticular tissues diagnosable clinically and by sonography techniques as well was regarded as a direct indication for sinovectomy that was performed in 8 patients. Therapeutic benefit from treatment occurred in 96 percent of patients.

[The diagnosis and combined treatment of humeral fractures complicated by involvement of the radial nerve]. / Diagnostika i kompleksnoe lechenie perelomov plechevoi kosti, oslozhnennykh porazheniem luchevogo nerva.

Diaphysis fractures of the brachium are frequent and rather severe lesions resulting in losses of working capacity for a long term. Diaphysis fractures in association with lesions of the radial nerve of varying severity equal from 3.2 to 17.5%. The authors advocate a complex approach to the diagnosis and treatment of this pathology in 15 patients with an 1 to 5 years following.

[The Whitaker perfusion test in the diagnosis of organic obstruction of the upper urinary tract]. / Perfuzionnyi test Whitaker v diagnostike organicheskoi obstruktsii verkhnikh mochevykh putei.

The X-ray and radioisotopic tools currently used in the diagnosis of upper urinary obstruction fail to take into account the dynamics of the ureter and largely depend on preserved renal function. Therefore Whitaker's test was proposed for this, which involves fluid perfusion along the nephrostomic drain and measurement of intrapelvic pressure. The test was employed in 40 patients and confirmed antegrade pyeloureterographic evidence in 32 (80%) patients, but failed in 8 (20%) patients who were suspected for upper urinary obstruction as shown by anterograde pyeloureterographic findings, whereas the perfusion test excluded the obstruction. The test provided evidence for the obstruction in 6 out of 26 cases, though antegrade pyeloureterography indicated as if the patency of the upper urinary tract were good. The results of Whitaker's test were supported by further clinical examinations and treatment of the patients. Two clinical cases are presented in the paper. It is concluded that Whitaker's perfusion test yields more accurate and objective data on the presence of organic obstruction of the upper urinary tract than do radioisotopic and X-ray tools. So the authors consider it advisable to apply it especially when it is questioned whether the obstruction is present or absent, as well as in patients undergone upper urinary plastic operations.

[Percutaneous endopyelotomy]. / Perkutannaia éndopielotomiia.

The paper deals with an endoscopic correction technique for ureteropelvic stricture, namely percutaneous endopyelotomy. The authors employed the technique in 16 patients both with primary and postoperative strictures of a ureteropelvic segment. Endopyelotomy was concomitant with nephrolith extraction in some cases. The diagnosis and outcomes of the therapy were assessed from X-ray, radioisotopic, and urodynamic findings. The specific features of percutaneous endopyelotomic techniques: paracentetic nephrostomy through the upper and middle calices, introduction of a guidewire along the ureter and an auxiliary wire into the pelvis, bougienage of the nephrostomic fistula and introduction of a nephroscope into the pelvis, dissection of the stricture using a cold knife, and splintage of the ureteropelvic stricture are also described. The authors note good results of the therapy and consider the technique to be highly effective. The technique is found to be superior to open pyeloplasty.

[Plasmapheresis in the complex treatment of nonspecific ulcerative colitis]. / Plazmotsitaferez v kompleksnoi terapii nespetsificheskogo iazvennogo kolita.

An experience with using the apparatus plasmacytapheresis in 16 patients with nonspecific ulcer colitis has revealed its high effectiveness mainly in patients with mild and middle-severity forms of the disease. Convincing data were obtained on the improvement of clinical, biochemical and immunological processes. The method can be used in ambulatory conditions for supporting therapy of the patients.

[The use of the polyene-resistant mutation model in Saccharomyces as a test-system for detecting genetically active substances]. / Ispol'zovanie modeli polienrezistentnykh mutatsii u drozhzhei-sakharomitsetov v kachestve test-sistemy dlia vyiavleniia geneticheski aktivnykh veshchestv.

The simple test-system has been developed to register mutagenic activity of different chemicals using a model of forward polyene-resistant mutations in Saccharomyces cerevisiae.

[Drainage of the thoracic duct in the complex treatment of progressive forms of multiple sclerosis]. / Drenirovanie grudnogo limfaticheskogo protoka v kompleksnoi terapii progredientnykh form rasseiannogo skleroza.

The results of clinical and modern immunological studies (assessment of T- and B-lymphocytes in the blood, cerebrospinal fluid and lymph) promoted the authors to operate (drainage of the thoracic lymphatic duct) on six patients with disseminated sclerosis to try to control their pathologically altered immune homeostasis. A rationale for a new type of pathogenetic therapy of progressive disseminated sclerosis which is tolerant to many therapeutic methods employed previously including immunodepression and immunostimulation is presented.