ABSTRACT
The detectability of delta-infection among patients with HB virus infections and their effects on the course of hepatitis B are discussed. Anti-delta were detected in 25.2% of 111 patients with HB virus infections. The course of the disease was more severe in cases of combined infection, and delta-superinfection was associated with the clinical picture of CAH, suggesting that combined B + delta infection may be producing a profound liver damage.
Subject(s)
Hepatitis B/complications , Hepatitis D/complications , Adolescent , Adult , Aged , Child , Child, Preschool , Female , Hepatitis Antibodies/analysis , Hepatitis D/diagnosis , Hepatitis D/immunology , Hepatitis Delta Virus/immunology , Humans , Infant , Male , Middle AgedABSTRACT
The paper is concerned with some data on the detection of markers of HBV infection (HBsAg, anti-HBs, HBeAg, anti-HBe, anti-HBc of IgM class) in 277 HB patients of different age groups using highly sensitive methods based on Soviet assays. A clinical course of HB in patients of different age groups was correlated with the regularities of the detection of markers of HBV infection. The diagnostic and prognostic importance of HBV antigens and antibodies to them was shown in patients of different age groups.
Subject(s)
Aging/immunology , Hepatitis B/diagnosis , Biomarkers/analysis , Convalescence , Hepatitis B Antibodies/analysis , Hepatitis B Surface Antigens/analysis , Hepatitis B e Antigens/analysis , Humans , Immunoglobulin M/analysis , Prognosis , Time FactorsABSTRACT
Patients of different age, among them 103 with viral hepatitis B and 120 with viral hepatitis A, were examined for immunoregulatory subpopulations of T lymphocytes and for the effects of HBsAg preparations and human liver-specific lipoprotein (LSL) on the blood E-RFC content. The patients of both mature and elderly age with viral hepatis A demonstrated insignificant, readily reversible alterations in cellular immunity. The patients with viral hepatitis B, particularly elderly ones, showed an evident tendency toward the predominance of the suppressor effects, which correlated with the disease gravity. During incubation of lymphocytes with HBsAg, the stimulating effect was mostly revealed. However, in elderly patients experiencing the stage of late convalescence, there was an increase in HBsAg-specific suppression depending on the disease gravity. The suppressive action of LSL was only recorded in single cases.
