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Hepatobiliary Pancreat Dis Int ; 13(4): 423-7, 2014 Aug.
Article in English | MEDLINE | ID: mdl-25100128

ABSTRACT

BACKGROUND: Although biliary decompression with metallic stenting is the preferred treatment for inoperable bile duct cancer (BDC), maintenance of patency is still unsatisfactory. We tried to assess the effectiveness and safety of external beam radiotherapy (EBRT) for prolonging stent patency in patients having uncovered metallic stents. METHOD: We retrospectively reviewed 50 patients who received endoscopic stenting, of whom 18 received EBRT (RT group) and 32 did not (non-RT group). RESULTS: No difference was found in baseline characteristics between the two groups. Although stent patency was longer in the RT group than that in the non-RT group (140.7+/-51.3 vs 136.4+/-34.9 days, P=0.94), the difference was not statistically significant. There were a lower rate of stent occlusion (27.8% vs 50.0% of patients, P=0.12) and a longer overall survival (420.1+/-73.2 vs 269.1+/-41.7 days, P=0.11) in the RT group than in the non-RT group, and the difference again was not statistically significant. The development of adverse reactions did not differ (55.6% vs 53.1% of patients, P=0.91). There was no serious adverse reaction in both groups (P=0.99). CONCLUSIONS: EBRT did not significantly improve stent patency in patients with inoperable BDC having uncovered metallic stents. However, EBRT was safe. Future trials with refined protocols for better efficacy are expected.


Subject(s)
Bile Duct Neoplasms/complications , Cholangiopancreatography, Endoscopic Retrograde/instrumentation , Cholestasis/therapy , Decompression/instrumentation , Dose Fractionation, Radiation , Metals , Stents , Aged , Bile Duct Neoplasms/diagnosis , Cholangiopancreatography, Endoscopic Retrograde/adverse effects , Cholestasis/diagnosis , Cholestasis/etiology , Cholestasis/radiotherapy , Decompression/adverse effects , Decompression/methods , Female , Humans , Male , Palliative Care , Prosthesis Design , Prosthesis Failure , Radiotherapy, Adjuvant , Retrospective Studies , Risk Factors , Time Factors , Treatment Outcome
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