A Comparative Evaluation of Factors that Affect the Retentive Efficacy of a Partially Customized Abutment Specifically Designed for Single Implant Application in the Esthetic Zone.

PURPOSE: The purpose of this study is to compare the factors of taper, length, angle and number of vertical axial walls that affect the retentive strength of a cemented crown on a partially customizedhybrid abutment in the esthetic zone. MATERIALS AND METHOD: A total of 35 metal copings were used in this study divided into one group with 30 copings cemented to their corresponding 8° tapered abutment with lengths from 3 to 8 mm with 1 mm increments. The remaining five consisted of a standardized metal coping matching a hexagonal abutment with 3 mm vertical axial walls and the sequential removal of 1, 2, and 3 contiguous vertical axial walls. Dislodgment tests were performed for all copings in both groups. Maximum retentive forces were measured in kgF with a conversion factor of 9.807 N to 1 kgF. RESULTS: At each tapered abutment length, the retentive strength increased proportionally and was significantly different from 31.67 ± SD 4.10 kgF to 67.68 ± SD 11.22 kgF, respectively [F (5,24) =20.46, p < 0.001]. An unmodified hexagonal abutment demonstrated the highest retentive strength of 70.15 ± SD 12.97 kgF. Sequential removal of 1, 2, and 3 contiguous vertical axial walls of the hexagonal abutment was 59.89 ± SD 10.06 kgF, 57.01 ± SD 9.62 kgF, and 55.99 ± SD 9.35 kgF, respectively with no significant difference (p > 0.05) in retentive strength. CONCLUSION: A partially customized abutment with vertical axial walls on one side and a profile reduction on the opposite side can provide comparable retention of cemented copings at 1/3 the length and 1/6 the surface area of an 8 mm high abutment with an 8° taper.

Mapping the Potential of Microfluidics in Early Diagnosis and Personalized Treatment of Head and Neck Cancers.

Head and neck cancers (HNCs) account for ~4% of all cancers in North America and encompass cancers affecting the oral cavity, pharynx, larynx, sinuses, nasal cavity, and salivary glands. The anatomical complexity of the head and neck region, characterized by highly perfused and innervated structures, presents challenges in the early diagnosis and treatment of these cancers. The utilization of sub-microliter volumes and the unique phenomenon associated with microscale fluid dynamics have facilitated the development of microfluidic platforms for studying complex biological systems. The advent of on-chip microfluidics has significantly impacted the diagnosis and treatment strategies of HNC. Sensor-based microfluidics and point-of-care devices have improved the detection and monitoring of cancer biomarkers using biological specimens like saliva, urine, blood, and serum. Additionally, tumor-on-a-chip platforms have allowed the creation of patient-specific cancer models on a chip, enabling the development of personalized treatments through high-throughput screening of drugs. In this review, we first focus on how microfluidics enable the development of an enhanced, functional drug screening process for targeted treatment in HNCs. We then discuss current advances in microfluidic platforms for biomarker sensing and early detection, followed by on-chip modeling of HNC to evaluate treatment response. Finally, we address the practical challenges that hinder the clinical translation of these microfluidic advances.

Induction Heating Triggers Antibiotic Release and Synergistic Bacterial Killing on Polymer-Coated Titanium Surfaces.

Infection is a major complication associated with orthopedic implants. It often involves the development of biofilms on metal substrates, which act as barriers to the host's immune system and systemic antibiotic treatment. The current standard of treatment is revision surgery, often involving the delivery of antibiotics through incorporation into bone cements. However, these materials exhibit sub-optimal antibiotic release kinetics and revision surgeries have drawbacks of high cost and recovery time. Herein, a new approach is presented using induction heating of a metal substrate, combined with an antibiotic-loaded poly(ester amide) coating undergoing a glass transition just above physiological temperature to enable thermally triggered antibiotic release. At normal physiological temperature, the coating provides a rifampicin depot for >100 days, while heating of the coating accelerates drug release, with >20% release over a 1-h induction heating cycle. Induction heating or antibiotic-loaded coating alone each reduce Staphylococcus aureus (S. aureus) viability and biofilm formation on Ti, but the combination causes synergistic killing of S. aureus as measured by crystal violet staining, determination of bacterial viability (>99.9% reduction), and fluorescence microscopy of bacteria on surfaces. Overall, these materials provide a promising platform enabling externally triggered antibiotic release to prevent and/or treat bacterial colonization of implants.

Biomimicry and 3D-Printing of Mussel Adhesive Proteins for Regeneration of the Periodontium-A Review.

Innovation in the healthcare profession to solve complex human problems has always been emulated and based on solutions proven by nature. The conception of different biomimetic materials has allowed for extensive research that spans several fields, including biomechanics, material sciences, and microbiology. Due to the atypical characteristics of these biomaterials, dentistry can benefit from these applications in tissue engineering, regeneration, and replacement. This review highlights an overview of the application of different biomimetic biomaterials in dentistry and discusses the key biomaterials (hydroxyapatite, collagen, polymers) and biomimetic approaches (3D scaffolds, guided bone and tissue regeneration, bioadhesive gels) that have been researched to treat periodontal and peri-implant diseases in both natural dentition and dental implants. Following this, we focus on the recent novel application of mussel adhesive proteins (MAPs) and their appealing adhesive properties, in addition to their key chemical and structural properties that relate to the engineering, regeneration, and replacement of important anatomical structures in the periodontium, such as the periodontal ligament (PDL). We also outline the potential challenges in employing MAPs as a biomimetic biomaterial in dentistry based on the current evidence in the literature. This provides insight into the possible increased functional longevity of natural dentition that can be translated to implant dentistry in the near future. These strategies, paired with 3D printing and its clinical application in natural dentition and implant dentistry, develop the potential of a biomimetic approach to overcoming clinical problems in dentistry.

The Effects of a Vertical Compressive Cyclic Load on Abutment Screws and the Stability of the Prosthesis in Nonengaging and Partially Engaging Abutments in a Screw-Retained Splinted Fixed Dental Prosthesis.

PURPOSE: To evaluate the effects of vertical compressive cyclic load on abutment screws and the stability of screw-retained splinted fixed dental prostheses supported by bone-level nonengaging and partially engaging abutments. MATERIALS AND METHODS: Ten standardized two-unit prostheses integrated with nonengaging and partially engaging abutments were 3D-printed and cast in nonprecious metal and attached to two implant analogs with conical connections angled 15 degrees toward the vertical axis in a resin bock. The common path of insertion for the prosthesis with partially engaging abutments to angled implant analogs was created by selectively reducing the abutment surface that obstructed the implant housing. A 500-N average load was applied to each sample while oscillating 30 degrees from the vertical axis at 60 Hz to failure. Prosthesis stability was measured by deflection from the initial position using a linear displacement measuring device. Sample groups were assessed using the independent-samples t test and one-way repeated-measures analysis of variance (ANOVA) with post hoc tests. RESULTS: The mean cycles to failure for nonengaging and partially engaging abutment groups were 27,180 ± 29,420 and 457,890 ± 265,734, respectively. Failed nonengaging samples had 9 out of 10 abutment screws fracture inside the implant housing but with minimal wear to the top of the implant analog. For partially engaging samples, 8 out of 10 implant housings and 7 out of 10 abutment screws fractured at test endpoints. There was no difference in initial deflections between groups. Prostheses supported by nonengaging abutments failed before deflection measurements could be taken after loading. Prosthesis displacement of partially engaged abutments decreased significantly from the initial position after 300,000 load cycles. CONCLUSION: Under the experimental conditions, screw-retained splinted fixed dental prostheses supported by partially engaging abutments are 17 times more stable than prostheses supported by nonengaging abutments. Abutment screw fractures are the most prevalent mode of failure for nonengaging abutments at significantly lower cycles with minimal wear on implant analogs. Partially engaging abutment groups failed from implant housing and abutment screw fractures at higher cycles. Loading appears to concentrate preferentially on the medial side on all angled implant components. Selective removal of the abutment obstruction allows a common path of insertion for multiple implants and partial engagement to implant housings.

Clinical Application of PEEK as a Provisional Fixed Dental Prosthesis Retained by Reciprocated Guide Surfaces of Healing Abutments During Dental Implant Treatment.

PURPOSE: The aim of this study was to evaluate the clinical use of a high-performance polymer, polyether ether ketone (PEEK), as a material for use in provisional fixed dental prostheses (FDPs) that can be retained by reciprocated guide surfaces of hexagonal-shaped healing abutments during dental implant treatment. MATERIALS AND METHODS: Patients requiring teeth replacement with dental implants for partially and fully edentulous cases in the maxilla and mandible were included. The provisional FDP was fabricated with hex castable copings and PEEK granules using the lost wax technique. The common path of insertion was established by reducing the coping that is in obstruction to the healing abutment. Retention was provided by the reciprocated guide surfaces of multiple hexagonal-shaped healing abutments. RESULTS: Twenty-three custom provisional PEEK FDPs supported by 166 implants in 20 partially and fully edentulous patients were provided during the treatment period. The mean functional periods of the provisional PEEK FDPs for maxillary and mandibular cases were 6.95 ± 0.84 months and 1.90 ± 0.62 months, respectively. All provisional PEEK FDPs functioned as intended for the entire treatment period. There were a total of 10 complications: 4 cases had resin and denture veneers debond from the PEEK framework; 3 partially edentulous cases required supplementary screw retention; and 3 implants in separate cases did not osseointegrate, requiring extended use of the provisional prosthesis. Two provisional mandibular PEEK FDPs with prolonged usage (over 2 years) were excluded from calculations. No fracture of the PEEK framework was observed. CONCLUSION: The results from this study suggest that PEEK can be a suitable material for use in provisional FDPs during dental implant treatment. Prosthetic complications were frequent but were resolved intraorally. The reciprocated guide surfaces of multiple hexagonal-shaped healing abutments can provide adequate retention and resistance for edentulous cases during the implant treatment period. However, in partially edentulous cases, a prosthesis without cross-arch stabilization supplementary screw retention was required.