1.
Bioorg Med Chem Lett
; 13(3): 413-7, 2003 Feb 10.
Article
in English
| MEDLINE
| ID: mdl-12565941
ABSTRACT
A new series of cyclooxygenase-2(COX-2) inhibitors with naturally occurring flavone as the main skeleton has been synthesized and their biological activities were evaluated for cyclooxygenase inhibitory activity. Rational structural modifications were applied to potent COX-2 inhibitors to obtain the desired pharmacokinetic profiles for improved oral anti-inflammatory activity.