ABSTRACT
BACKGROUND: Seizure can be triggered by the non-ketotic hyperglycemia (NKH). Recently we analysed 18 cases of NKH induced seizure to identify the causes for NKH, seizure types, prognosis, and the differences of clinical presentation between the patient with chronic brain structural lesion (CBSL) and the patient without. METHODS: Eighteen patients with NKH induced seizure were selected from the database. Data regarding brain images, clinical symptoms, co-morbid illnesses, blood laboratories, and prognosis were collected. Patients were divided into two groups according to the presence of CBSL. RESULTS: The patients with CBSL showed more generalized tonic-clonic seizure (GTCS) than without. Focal seizures in this group appeared to be originated from the pre-existing lesion in many situations. The poor compliance to anti-diabetic treatment and physical stresses were most common causes for NKH. One year seizure remission without anti-epileptic drug treatment was achieved in 17 of 18 patients. CONCLUSIONS: The patients with CBSL might have more GTCS than without. The impairment of inhibitory mechanism surrounding the focal irritative zone might be one of plausible explanation for this phenomenon. The prognosis was favorable. Further large studies are required.
Subject(s)
Humans , Brain , Compliance , Hyperglycemia , Prognosis , SeizuresABSTRACT
OBJECTIVE: Perfusion computed tomography (PCT) has the ability to measure quantitative value and produce maps of mean transit time (MTT), cerebral blood flow (CBF), and cerebral blood volume (CBV). We assessed cerebral hemodynamics by using these parameters and acetazolamide (ACZ) challenge for pre- and post-procedural evaluation in patients with unilateral cerebrovascular stenotic disease. METHODS: Thirty patients underwent pre-procedural PCT with ACZ challenge, and 24 patients (80%) was conducted follow up PCT after angioplasty with same protocol. The mean MTT, CBF, and CBV were measured and compared in both middle cerebral arterial (MCA) territories before and after ACZ challenge. Hemispheric ratio and percent change after ACZ challenge were calculated before and after angioplasty. RESULTS: The mean stenosis rate was 76.6%. Significant increases in MTT (32.6%, p=0.000) and significant decreases in CBF (-14.2%, p=0.000) were found in stenotic side MCA territories. After ACZ challenge, there were significant changes in MTT (37.4%, p=0.000), CBF (-13.1%, p=0.000), and CBV (-10.5%, p=0.001) in pre-procedural perfusion study. However, no significant increases were found in MTT, or decreases in CBF and CBV in post-procedural study. There were no significant changes after ACZ challenge also. In addition, the degrees of these changes (before and after ACZ challenge) were highly correlated with the stenotic degrees in pre-procedural perfusion study. CONCLUSION: PCT with ACZ challenge appears to be a useful tool to assess the cerebral perfusion status especially in patients with unilateral symptomatic stenotic disease.
Subject(s)
Humans , Acetazolamide , Angioplasty , Blood , Blood Volume , Constriction, Pathologic , Follow-Up Studies , Hemodynamics , PerfusionABSTRACT
Cerebrospinal fluid (CSF) plays an important role in providing brain tissue with a stable internal environment as well as in absorbing mechanical and thermal stresses. From its initial composition, derived from the amniotic fluid trapped by the closure of neuropores, CSF is modified by developing and differentiating ependymal cells lining the ventricular surface or forming the choroid plexus. Its osmolarity and ionic composition brings about a change through the action of many channels expressed on the ependymal cells. Some newly discovered transient receptor potential (TRP) channels are known to be expressed in the choroid plexus ependyma. To detect additional TRP channel expression, immunohistochemical screening was performed at the choroid plexus of 13-, 15-, 17-, and 19-day embryos, using antibodies against TRPV1, TRPV3, and TRPA1, and the expression was compared with those in the adult TRP channels. The level of TRP channel expression was higher in the choroid plexus which suggests more active functioning of TRP channels in the developing choroid plexus than the ventricular lining ependyma in the 15- and 17-day embryos. All the expression of TRP channels decreased at the 19th day of gestation. TRPA1 was expressed at a higher level than TRPV1 and TRPV3 in almost all stages in both the choroid plexus and ventricular lining epithelium. The highest level of TRPV1 and TRPV3 expression was observed in association with the glycogen deposits in the cytoplasm of the choroid plexus ependymal cells of the 15- and 17-day embryos.
Subject(s)
Adult , Animals , Female , Humans , Pregnancy , Rats , Amniotic Fluid , Antibodies , Brain , Choroid Plexus , Cytoplasm , Embryonic Development , Embryonic Structures , Ependyma , Epithelium , Glycogen , Mass Screening , Osmolar Concentration , Transient Receptor Potential ChannelsABSTRACT
Spontaneous bilateral cerebellar infarction in the territory of the superior cerebellar arteries is extremely rare. Occasionally there have been reports of bilateral cerebellar infarction due to vertebrobasilar atherosclerotic occlusion or stenosis, whereas no report of bilateral cerebellar infarction due to complicated hemodynamic changes. In this report, we present a patient with bilateral cerebral infarctions related to stenoses of bilateral internal carotid arteries, in whom vertebrobasilar system was supplied by multiple collaterals from both posterior communicating arteries and right external carotid artery. We performed stent-angioplasty of bilateral internal cerebral arterial stenosis, and then acute infarction developed on bilateral superior cerebellar artery territories. The authors assumed that the infarction occurred due to hemodynamic change between internal carotid artery and external carotid artery after stent-angioplasty for stenosis of right internal carotid artery.
Subject(s)
Humans , Arteries , Carotid Artery, External , Carotid Artery, Internal , Carotid Stenosis , Cerebral Infarction , Constriction, Pathologic , Hemodynamics , InfarctionABSTRACT
OBJECTIVE: The purpose of this study is to investigate the results of treatment using stent-angioplasty for symptomatic middle cerebral arterial (MCA) stenosis and comparison of in-stent restenosis between drug-eluting stents (DES), bare metal coronary stents (BMS) and self-expanding stents (SES). MATERIALS AND METHODS: From Jan. 2007 to June. 2012, 34 patients (mean age +/- standard deviation: 62.9 +/- 13.6 years) with MCA stenosis were treated. Inclusion criteria were acute infarction or transient ischemic attacks (TIAs) and angiographically proven symptom related severe stenosis. Stents used for treatment were DES (n = 8), BMS (n = 13) and SES (n = 13). National Institutes of Health Stroke Scale (NIHSS) at admission was 2.5 +/- 3.1 and mean stenosis rate was 79.0 +/- 8.2%. Assessment of clinical and angiographic results was performed retrospectively. RESULTS: Among 34 patients, periprocedural complications occurred in four cases (11.8%), however, only two cases (6.0%) were symptomatic. All patients were followed clinically (mean follow-up period; 40.7 +/- 17.7 months) and 31 were followed angiographically (91.2%. 13.4 +/- 8.5 months). There was no occurrence of repeat stroke in all patients; however, mild TIAs related to restenosis occurred in three of 34 patients (8.8%). The mean NIHSS after stent-angioplasty was 1.7 +/- 2.9 and 0.8 +/- 1.1 at discharge. The modified Rankin score (mRS) at discharge was 0.5 +/- 0.9 and 0.3 +/- 0.8 at the last clinical follow-up. In-stent restenosis over 50% occurred in five of 31 angiographically followed cases (16.1%), however, all of these events occurred only in patients who were treated with BMS or SES. Restenosis rate was 0.0% in the DES group and 20.8% in the other group (p = 0.562); it did not differ between BMS and SES (2/11 18.2%, 3/13 23.1%, p = 1.000). CONCLUSION: Stent-angioplasty appears to be effective for symptomatic MCA stenosis. As for restenosis, in our study, DES was presumed to be more effective than BMS and SES; meanwhile, the results did not differ between the BMS and SES groups.
Subject(s)
Humans , Angioplasty , Constriction, Pathologic , Drug-Eluting Stents , Follow-Up Studies , Infarction , Ischemic Attack, Transient , Middle Cerebral Artery , Stents , StrokeABSTRACT
No abstract available.
Subject(s)
Cerebral Infarction , Diffusion Magnetic Resonance Imaging , Polycythemia , Polycythemia VeraABSTRACT
The persistent trigeminal artery(PTA) is the most common type of persistent carotid-basilar anastomosis, usually diagnosed by cerebral angiography or autopsy. PTA is usually associated with hypoplasia or atresia of the vertebrobasilar artery and may result in symptoms of vertebrobasilar insufficiency caused by decreased perfusion of the brainstem. We report a patient with PTA who presented with symptoms of vertebrobasilar insufficiency. An 80-year-old woman with a history of hypertension, hyperlipidemia, and unstable angina pectoris presented with recurrent dizziness, dysarthria, and a tendency to fall to the left side. PTA was identified with hypoplasia of the vertebrobasilar system and mild stenosis of the bilateral proximal internal carotid arteries on brain MR angiography and cerebral angiography.
Subject(s)
Aged, 80 and over , Female , Humans , Angina, Unstable , Angiography , Arteries , Autopsy , Brain , Brain Stem , Carotid Artery, Internal , Cerebral Angiography , Constriction, Pathologic , Dizziness , Dysarthria , Hyperlipidemias , Hypertension , Magnetic Resonance Angiography , Perfusion , Vertebrobasilar InsufficiencyABSTRACT
PURPOSE: To evaluate the usefulness of post-enhanced delayed FLAIR (fluid-attenuated inversion-recovery) images in the diagnosis of leptomeningitis. MATERIALS AND METHODS: We obtained the pre- and post-enhanced FLAIR images of 7 rabbits every hour after infusing triple doses of contrast, and we measured the signal intensities of the CSF (cerebrospinal fluid) and the brain parenchyma. Five leptomeningitis patients and 5 volunteers were enrolled to obtain the pre-enhanced FLAIR images, the early post-enhanced FLAIR images and the delayed post-enhanced FLAIR images, with using a standard dose of contrast, and to measure the signal intensities of the CSF and brain parenchyma. The statistical significances were determined by a mixed procedure and the Wilcoxon rank-sum test (p<0.05). RESULTS: In the rabbits, the signal intensities of the CSF began to increase after an hour of contrast infusion, but those of the parenchyma did not increase. The time of maximum CSF enhancement was 2 hours after contrast infusion (p<0.001; standard estimate=750.43) and we obtained the post-enhanced delayed FLAIR images for clinical studies according to this result. The signal intensities of the CSF in the subarachnoid space were higher in the patient group compared with those of the normal control group on both the early post-enhanced FLAIR images and the delayed post-enhanced FLAIR images (p=0.0096) (p=0.0391). In the patient group, changes of signal intensities of the CSF in the subarachnoid space were more conspicuous on the delayed post-enhanced FLAIR images than on the early post-enhanced FLAIR images (p=0.0042). However, those of the parenchyma were not different in either group. CONCLUSION: The post-enhanced delayed FLAIR images obtained at 2 hours after contrast infusion are more useful for making the the diagnosis of leptomeningitis than are the post-enhanced early FLAIR images.
Subject(s)
Humans , Rabbits , Brain , Diagnosis , Meningitis , Subarachnoid Space , VolunteersABSTRACT
Loss of pain and temperature sensation due to lateral medullary infarction are well known and classically involve the ipsilateral side of the face and the lower part of the body on the controlateral side. This pattern of sensory loss below a certain level on the trunk, usually a sign of spinal cord disease, may also appear following a lesion in the lateral medullar, due to damage to the spinothalamic tract. A 72-year-old hypertensive man developed sudden dizziness, headache, and gait ataxia. On neurologic examination, he had left limb and gait ataxia. Five days later he noted loss of pain and temperature sensation on the right leg and trunk with a sensory level at T4 with preservation of touch, vibration, and joint position sense in all limbs. Brain MRI showed a small infarct in the left lower lateral medulla. Brain MR angiography showed stenosis of the right proximal carotid artery, left distal vertebral artery, and mid-basilar artery. We report a case of sensory defects with a sensory level on the trunk that occured as the result of lesion of the lower lateral medulla.
Subject(s)
Aged , Humans , Angiography , Arteries , Brain , Carotid Arteries , Constriction, Pathologic , Dizziness , Extremities , Gait Ataxia , Headache , Infarction , Joints , Leg , Magnetic Resonance Imaging , Medulla Oblongata , Neurologic Examination , Proprioception , Sensation , Spinal Cord Diseases , Spinothalamic Tracts , Vertebral Artery , VibrationABSTRACT
No abstract available.
Subject(s)
Humans , Evoked Potentials , Neural Conduction , PoisoningABSTRACT
Eclampsia is a syndrome characterized by pregnancy-induced hypertension, edema, proteinuria, and generalized tonic-clonic convulsions, occurring between 20 and 40 weeks of gestation or within 48 hours of postpartum. A convulsion that shows up more than 48 hours after delivery is late postpartum eclampsia. A 40-year-old woman was admitted due to a headache and generalized tonic-clonic seizures in 14 days of postpartum. Two months prior to the admission, she had been admitted to the hospital because of mild proteinuria. Her blood pressure on arrival was 160/100 mmHg. There were no focal neurologic signs. She was given lorazepam and valproate sodium intravenously and her convulsion was stopped. A brain MRI showed multiple bilateral high signal intensities in the both deep white matter and the parieto-occipital cortex. Cerebral angiography showed a diffuse vasospasm. We report a patient with late postpartum eclampsia occurring 14 days after parturition whose seizures was accompanied by preceding headache and proteinuria as a pre-eclamptic sign.
Subject(s)
Adult , Female , Humans , Pregnancy , Blood Pressure , Brain , Cerebral Angiography , Eclampsia , Edema , Headache , Hypertension, Pregnancy-Induced , Lorazepam , Magnetic Resonance Imaging , Neurologic Manifestations , Parturition , Postpartum Period , Proteinuria , Seizures , Valproic AcidABSTRACT
Fibromuscular dysplasia (FMD) is a rare, segmental nonatheromatous angiopathy of unknown etiology affecting small to medium-sized arteries. The most common angiographic pattern is the classic string-of-beads appearance. But the tubular stenosis type of the FMD is a rare finding and has not been reported previously. We report a case who presented with recurrent intracerebral hemorrhages, whose angiographic features were long tubular stenosis type of FMD affecting the both internal carotid arteries associated with terminal carotid occlusions.
Subject(s)
Arteries , Carotid Artery, Internal , Cerebral Hemorrhage , Constriction, Pathologic , Fibromuscular DysplasiaABSTRACT
Rasmussen's encephalitis is a rare autoimmune disorder characterized by intractable epilepsy and progressive unilateral hemispheric dysfunction as well as mental deterioration. Although the disorder typically begins in childhood, a few cases have been reported with symptom onset in adulthood showing variable clinical characteristics. We report a 63-year-old woman with adult-onset partial seizure with intermittent secondary generalization, progressive right hemiparesis, and aphasia, who showed positive response to high-dose steroid and antiepileptic drugs.
Subject(s)
Female , Humans , Middle Aged , Anticonvulsants , Aphasia , Encephalitis , Epilepsy , Generalization, Psychological , Paresis , SeizuresABSTRACT
Lateral medullary syndrome is one of the most well known and best characterized vascular syndromes of the vertebrobasilar circulation. This syndrome is most often caused by unilateral occlusive disease of the ipsilateral vertebral artery or its posterior inferior cerebellar artery branch. Bilateral lateral medullary syndromes are rare and the prognosis of this condition is grave. A 70-year-old hypertensive, diabetic woman developed sudden dizziness and gait ataxia. On neurologic examination, she had dysarthria, hoarseness, nystagmus, absent gag reflex, sensory changes on the right hemibody, and left limb and gait ataxia. Brain MRI revealed left middle and inferior lateral medullar infarction. Brain MR angiography revealed occlusion of the right vertebral artery and mild stenosis at the origin of the left vertebral artery with distal occlusion. Seven months later, she developed right lateral medullary syndrome. Repeated brain MRI revealed right upper lateral medullar and cerebellar infarction. We report a case of bilateral lateral medullary syndromes due to two consecutive medullary infarcts.
Subject(s)
Aged , Female , Humans , Angiography , Arteries , Brain , Brain Stem Infarctions , Constriction, Pathologic , Dizziness , Dysarthria , Extremities , Gait Ataxia , Hoarseness , Infarction , Lateral Medullary Syndrome , Magnetic Resonance Imaging , Neurologic Examination , Prognosis , Reflex , Vertebral ArteryABSTRACT
Water intoxication associated with hyponatremia is a rare and sometimes fatal complication of oxytocin. We report a 18-year-old primigravida who presented with vomiting, seizures, and stuporous mental state after abortion with oxytocin infusion. The serum sodium was 116 mEq/L and serum osmolality was 234 mosm/kg. The serum sodium level as well as clinical symptoms were improved after hypertonic saline infusion. We suggest that the serum electrolytes and osmolarity should be examined in patients who presenting with seizure and altered mental state with history of labour or abortion.
Subject(s)
Adolescent , Humans , Electrolytes , Hyponatremia , Osmolar Concentration , Oxytocin , Seizures , Sodium , Stupor , Vomiting , Water IntoxicationABSTRACT
Methyl bromide is presently used as a fumigant for insects in soil, grains or fruit in storage or transport. It is a neurotoxic agent and has been responsible a number of deaths or acute poisonings among occupationally exposed persons. We report 2 patients, who had worked fumigation warehouse, presented with seizures and altered mental state. The serum concentrations of bromide were elevated 32.9 and 42.5 mg/l, respectively. Brain MRI showed bilateral symmetric high signal intensities in the splenium of corpus callosum, the globus pallidus, the quadrigeminal plate, the periaqueductal gray matter, the red nucleus, the substantia nigra, the medial lemniscus, the pontine tegmentum, the dentate nucleus, and the medulla. There was no brain lesion in the other patient. Appropriate and supervised handling of the chemical and regular education to workers are important to avoid the risk of methyl bromide poisoning.
Subject(s)
Humans , Brain , Edible Grain , Cerebellar Nuclei , Corpus Callosum , Education , Fruit , Fumigation , Globus Pallidus , Insecta , Magnetic Resonance Imaging , Occupations , Periaqueductal Gray , Poisoning , Red Nucleus , Seizures , Soil , Substantia Nigra , Tectum MesencephaliABSTRACT
PURPOSE: To compare the reliability of lateralization between seizure semiology and ictal scalp EEG findings in mesial temporal lobe epilepsy (MTLE) patients, and to examine the advantage of the combined use of these two methods. METHODS: We independently reviewed the ictal scalp EEG recordings and clinical seizure semiology of 243 seizures recorded in 58 consecutive MTLE patients. All patients were seizure-free for at least 1 year postoperatively. Each seizure was lateralized on the basis of ictal semiology and ictal scalp EEG patterns according to strictly defined criteria, respectively. Individual patients were also lateralized based on these data. RESULTS: Seizure semiology analysis lateralized 64.6 % of seizures and 82.8 % of patients. Ictal scalp EEG analysis lateralized 74.5% of seizures and 74.1% of patients. Combination of the information from the two methods allowed for lateralization in a greater portion of both seizures (79.8%) and patients (89.7%). CONCLUSION: This study suggests that combination of ictal scalp EEG findings and seizure semiology improves the lateralization of individual seizures and patients. Therefore, it is worth lateralizing with standardized combined ictal EEG and semiology analysis for noninvasive presurgical evaluation in TLE patients.
Subject(s)
Humans , Electroencephalography , Epilepsy, Temporal Lobe , Scalp , Seizures , Temporal LobeABSTRACT
A 49-year-old woman was admitted with a three-month history of myalgia and progressive proximal and distal muscle weaknesses. Physical examination showed diffuse enlargement of the thyroid gland and mild muscle atrophy. Serum creatine kinase was slightly increased and electromyography showed a myopathic pattern. Muscle biopsy showed nonspecific myopathic changes. Serum thyroid-stimulating hormone was very low, whereas thyroxine (T4) was greatly increased as well as anti-thyroglobulin, anti-microsome, and TSH-receptor antibody. The patient's symptoms were improved during the treatment with propilthiouracil.
Subject(s)
Female , Humans , Middle Aged , Biopsy , Creatine Kinase , Electromyography , Graves Disease , Hyperthyroidism , Muscle Weakness , Muscular Atrophy , Muscular Diseases , Myalgia , Physical Examination , Thyroid Gland , Thyrotropin , ThyroxineABSTRACT
BACKGROUND: Intracranial lipomas are uncommon benign lesions of the central nervous system. They preferentially occur near the midline, most frequently in the pericallosal cistern, and are often associated with various neurologic and systemic anomalies. Since the advent of CT scanning and MR imaging, unexpected findings of intracralial lipomas have increased. We identified 11 cases of intracranial lipomas diagnosed by CT and MR and analyzed their characteristic clinical and radiologic findings. METHODS: We retrospectively reviewed 11 cases of intracranial lipomas. MR was used in all cases and CT in three. RESULTS: There were seven men and four women whose ages ranged from six months to 76 years, with a mean of 39 years. Six (55%) lipomas were located in the quadrigeminal plate and five (45%) in the pericallosal area. The pericallosal lipomas were divided into three cases of curvilinear type and two cases of tubulonodular type. Of the six quadrigeminal lipomas, five cases (83%) were associated with either hypoplasia of the unilateral (four) or bilateral (one) superior and/or inferior colliculus. One case of quadrigeminal lipoma was associated with hypoplasia of the cerebellar vermis, agenesis of the septum pellucidum, and glioblastoma multiforme. All cases of pericallosal tubulonodular type were associated with dysgenesis of the corpus callosum and enlarged ventricles. However, all cases of pericallosal curvilinear type were not associated with other anomalies. Four (36%) cases found incidentally were asymptomatic. Seizure was the most frequent clinical presentation in five (45%) cases, followed by headaches in three (27%) and mental retardation in one (9%). Of five seizures cases, three had secondary generalized seizures and two had generalized tonic clonic seizures. CONCLUSIONS: Quadrigeminal and pericallosal lipomas were the most common types of intracranial lipomas. Sixty-three percent of the lesions were associated with adjacent brain malformations of varying degrees. Four cases were asymptomatic, while the others presented with seizures, headache, and mental retardation. (J Korean Neurol Assoc 19(2):149~154, 2001)
Subject(s)
Female , Humans , Male , Brain , Brain Neoplasms , Central Nervous System , Corpus Callosum , Glioblastoma , Headache , Inferior Colliculi , Intellectual Disability , Lipoma , Magnetic Resonance Imaging , Retrospective Studies , Seizures , Septum Pellucidum , Tectum Mesencephali , Tomography, X-Ray ComputedABSTRACT
BACKGROUND: Intracranial lipomas are uncommon benign lesions of the central nervous system. They preferentially occur near the midline, most frequently in the pericallosal cistern, and are often associated with various neurologic and systemic anomalies. Since the advent of CT scanning and MR imaging, unexpected findings of intracralial lipomas have increased. We identified 11 cases of intracranial lipomas diagnosed by CT and MR and analyzed their characteristic clinical and radiologic findings. METHODS: We retrospectively reviewed 11 cases of intracranial lipomas. MR was used in all cases and CT in three. RESULTS: There were seven men and four women whose ages ranged from six months to 76 years, with a mean of 39 years. Six (55%) lipomas were located in the quadrigeminal plate and five (45%) in the pericallosal area. The pericallosal lipomas were divided into three cases of curvilinear type and two cases of tubulonodular type. Of the six quadrigeminal lipomas, five cases (83%) were associated with either hypoplasia of the unilateral (four) or bilateral (one) superior and/or inferior colliculus. One case of quadrigeminal lipoma was associated with hypoplasia of the cerebellar vermis, agenesis of the septum pellucidum, and glioblastoma multiforme. All cases of pericallosal tubulonodular type were associated with dysgenesis of the corpus callosum and enlarged ventricles. However, all cases of pericallosal curvilinear type were not associated with other anomalies. Four (36%) cases found incidentally were asymptomatic. Seizure was the most frequent clinical presentation in five (45%) cases, followed by headaches in three (27%) and mental retardation in one (9%). Of five seizures cases, three had secondary generalized seizures and two had generalized tonic clonic seizures. CONCLUSIONS: Quadrigeminal and pericallosal lipomas were the most common types of intracranial lipomas. Sixty-three percent of the lesions were associated with adjacent brain malformations of varying degrees. Four cases were asymptomatic, while the others presented with seizures, headache, and mental retardation. (J Korean Neurol Assoc 19(2):149~154, 2001)