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2.
Acta Neurochir (Wien) ; 150(4): 351-8; discussion 358, 2008 Apr.
Article in English | MEDLINE | ID: mdl-18297232

ABSTRACT

BACKGROUND: Placement of detachable coil(s) for intracranial aneurysms has become one of the standard methods of management. Although detailed analysis of post-procedure changes in aneurysmal lumen is essential, technical difficulties often limit such evaluation. Development of higher magnetic field systems is steadily widening clinical usage of magnetic resonance imaging (MRI) primarily due to its significantly higher signal to noise ratio. OBJECTIVE: In this study, we evaluated a multi-planar reconstruction (MPR) technique of magnetic resonance angiography (MRA) on a 3.0T system in an attempt to develop a routine method of post-procedure evaluation following detachable coil placement. METHODS: Eleven patients with an intracranial aneurysm following placement of a Guglielmi detachable coil (GDC) participated in the study. Time of flight (TOF) magnetic resonance angiography (MRA) was obtained immediately after, and up to two years after coil embolisation utilising a GE 3.0T system. Data was analysed using standard maximum intensity projection (MIP) as well as the MPR technique and the results were compared to conventional catheter angiography. RESULTS: The study demonstrated that, compared to MIP, MPR can provide further information of alteration in aneurysm lumen, especially in analysis of: 1) jet of blood flow, 2) thrombus formation, 3) neck remnant or re-filling of blood, 4) location and shape of coils including compaction, and 5) coil protrusion into the parent artery. CONCLUSIONS: Combined MPR/MIP analysis of high-field MRA appears to be a powerful non-invasive method for evaluating GDC-treatment that can potentially replace conventional catheter angiography in many clinical situations.


Subject(s)
Embolization, Therapeutic , Image Processing, Computer-Assisted , Imaging, Three-Dimensional , Intracranial Aneurysm/therapy , Magnetic Resonance Angiography , Adult , Aged , Angiography, Digital Subtraction , Cerebral Arteries/pathology , Equipment Failure , Female , Follow-Up Studies , Humans , Intracranial Aneurysm/pathology , Magnetic Resonance Angiography/instrumentation , Male , Middle Aged , Sensitivity and Specificity
3.
Eur Neurol ; 46(3): 121-5, 2001.
Article in English | MEDLINE | ID: mdl-11598329

ABSTRACT

Functional magnetic resonance imaging studies on spoken versus written language processing were performed in 20 right-handed normal volunteers on a high-field (3.0-tesla) system. The areas activated in common by both auditory (listening) and visual (reading) language comprehension paradigms were mapped onto the planum temporale (20/20), primary auditory region (2/20), superior temporal sulcus area (2/20) and planum parietale (3/20). The study indicates that the planum temporale represents a common traffic area for cortical processing which needs to access the system of language comprehension. The destruction of this area can result in comprehension deficits in both spoken and written language, i.e. a classical case of Wernicke's aphasia.


Subject(s)
Magnetic Resonance Imaging , Reading , Speech Perception/physiology , Temporal Lobe/physiopathology , Visual Perception/physiology , Adolescent , Adult , Aphasia, Broca/physiopathology , Aphasia, Wernicke/physiopathology , Auditory Cortex/physiopathology , Brain Mapping , Female , Humans , Male , Neural Pathways/physiopathology , Parietal Lobe/physiopathology , Reference Values
4.
Neurosci Res ; 40(4): 351-8, 2001 Aug.
Article in English | MEDLINE | ID: mdl-11463481

ABSTRACT

Brain activation associated with reading was investigated in ten normal Japanese volunteers (five highly literate in both Japanese and English) and ten American native English speakers (five highly literate in both English and Japanese) in order to determine the neuroanatomic substrates employed in reading the first language (L1), and to determine the effect of L1 on the neurosubstrates involved in reading the second language (L2). The study was performed using blood oxygenation level dependent (BOLD) contrast functional magnetic resonance imaging (fMRI) on a high-field (3.0T) system specifically optimized for fMRI. The activation patterns in Japanese subjects reading Japanese (L1) were substantially different from the patterns obtained in American subjects reading English text (L1). The activation patterns reading L2 were virtually identical to the patterns seen when reading L1 in both Japanese and English natives highly literate in both language systems. The results demonstrated that the neuroanatomical substrates underlying the cognitive processing of reading are differentially determined based on the language system. The study further indicates that the cognitive processes for reading in the second language involve the same cortical structures employed for the first language, supporting the hypothesis that the second language represents the cognitive extension of the first language.


Subject(s)
Cerebral Cortex/physiology , Cerebrovascular Circulation/physiology , Language , Reading , Verbal Behavior/physiology , Adult , Brain Mapping , Cerebral Cortex/anatomy & histology , Functional Laterality/physiology , Humans , Magnetic Resonance Imaging
5.
Brain Res ; 907(1-2): 208-21, 2001 Jul 13.
Article in English | MEDLINE | ID: mdl-11430904

ABSTRACT

The purpose of this study was to determine whether regional differences in metabolites can be seen chronologically in permanent focal cerebral ischemia using 1H magnetic resonance spectroscopic imaging (MRSI), and whether these changes reflect pathological outcome. Regional variation in metabolites after permanent focal ischemia were investigated longitudinally in rats using 1H MRSI for a total of 7 days and then compared to histopathological findings. Four hours after the induction of ischemia, N-acetyl-L-aspartate (NAA) levels in the lateral caudo-putamen and the somatosensory cortex, core ischemic regions, decreased 22 and 40%, respectively. This reduction in NAA was coupled with a marked rise in lactate. In the medial caudo-putamen, the ischemic rim, however, NAA was preserved in spite of a marked increase in lactate. By 24 h post ischemia, the levels of NAA in medial caudo-putamen (ischemic rim in caudate) also decreased significantly. However NAA in cingulated cortex (ischemic rim in cortex) decreased more gradually between 24 and 48 h. This regional difference can reflect the severity of metabolic derangement in the acute stage. After 96 h following ischemia, the levels of all metabolites detected by 1H MRSI had decreased and the levels of NAA decline reflected the severity of histopathological damage. In conclusion, the regional metabolic differences could be assessed by 1H MRSI chronologically, and the depth of NAA decline reflected histopathological changes in the chronic stage.


Subject(s)
Brain Ischemia/metabolism , Magnetic Resonance Imaging , Animals , Aspartic Acid/analogs & derivatives , Aspartic Acid/analysis , Biomarkers , Brain Ischemia/pathology , Caudate Nucleus/metabolism , Circle of Willis , Energy Metabolism , Glutamic Acid/analysis , Glutamine/analysis , Gyrus Cinguli/metabolism , Ligation , Magnetic Resonance Imaging/methods , Male , Necrosis , Putamen/metabolism , Rats , Rats, Sprague-Dawley , Somatosensory Cortex/metabolism , Time Factors , gamma-Aminobutyric Acid/analysis
6.
Neurosci Res ; 37(3): 237-44, 2000 Jul.
Article in English | MEDLINE | ID: mdl-10940458

ABSTRACT

A new technique for functional magnetic resonance imaging (fMRI) time series analysis is presented. The technique referred to here as independent component-cross correlation-sequential epoch (ICS) analysis is a hybrid technique of two standard methodologies of biological signal analysis, namely, data driven methods, represented by independent component analysis, and hypothesis driven methods, represented by a general linear model. The technique successfully identified four functionally discrete areas within the primary sensorimotor cortex (SMI) in normal human subjects based on blood oxygenation level dependent (BOLD) contrast functional magnetic resonance imaging (fMRI) time series performed on a high field (3.0 T) system. Each of the four areas identified corresponded to the four physiological subdivisions of SMI, recognized in primates to be essential for voluntary hand motion, namely, 4 anterior (MI-4a) and 4 posterior (MI-4p) of the primary motor cortex, and 3a and the 'classical' (Brodmann areas 1, 2, and 3b) primary sensory cortex, respectively. ICS analysis appears to be a highly reliable and versatile technique for fMRI time series analysis.


Subject(s)
Magnetic Resonance Imaging/methods , Motor Cortex/physiology , Algorithms , Humans , Motor Cortex/blood supply , Oxygen/blood , Somatosensory Cortex/blood supply , Somatosensory Cortex/physiology
7.
Neurology ; 53(7): 1599-601, 1999 Oct 22.
Article in English | MEDLINE | ID: mdl-10534279

ABSTRACT

Cortical activation associated with stereopsis was studied in eight right-handed neurosurgeons professionally trained in stereoscopic vision. The activation map associated with viewing three-dimensional images, as contrasted to viewing the corresponding two-dimensional images of identical contents (images of MR angiography), showed consistent activation in the cortex adjacent to the intraparietal sulcus. The study further demonstrated a dominant role of the right hemisphere in perceptual processing of stereopsis in humans.


Subject(s)
Depth Perception/physiology , Magnetic Resonance Imaging , Mental Processes/physiology , Perception/physiology , Adult , Brain/anatomy & histology , Brain Mapping , Humans , Magnetic Resonance Angiography , Male , Oxygen/blood , Reproducibility of Results
8.
J Neurosurg ; 90(4): 791-5, 1999 Apr.
Article in English | MEDLINE | ID: mdl-10193629

ABSTRACT

The utility of three-dimensional anisotropy contrast (3DAC) magnetic resonance (MR) axonography, a method sensitive to neuronal fibers and their directionality, was investigated in the clinical setting using a 3-tesla MR imaging system based on a General Electric Signa platform. The study focused on healthy volunteers and patients with common structural central nervous system disorders, namely chronic infarction, brainstem cavernous hemangioma, supratentorial meningioma, and astrocytoma. Three orthogonal anisotropic diffusion-weighted images were first obtained. Three primary colors were each assigned to a diffusion-weighted image, respectively, and the images were subsequently combined into a single-color image in full-color spectrum (3DAC MR axonography image). Fiber-tract definition in the cerebral peduncle of the midbrain of healthy volunteers showed intersubject variation, with two general patterns recognized: dispersed (60% of cases) and compact (40% of cases). Pathological alterations in the fiber tracts were readily identified in cases involving wallerian degeneration of the pyramidal tract, as illustrated in the cases of chronic infarction. Displacement of major tracts, such as the medial lemniscus or corticospinal tract, as well as fiber directionality, was also easily recognized in cases of mass lesions. As an imaging method uniquely capable of providing information regarding axonal connectivity, 3DAC MR axonography appears to have promising potential for routine clinical application.


Subject(s)
Axons/ultrastructure , Image Processing, Computer-Assisted/methods , Magnetic Resonance Imaging/methods , Astrocytoma/ultrastructure , Brain Neoplasms/ultrastructure , Brain Stem/ultrastructure , Cerebral Infarction/pathology , Chronic Disease , Color , Diffusion , Hemangioma, Cavernous/ultrastructure , Humans , Image Processing, Computer-Assisted/instrumentation , Magnetic Resonance Imaging/instrumentation , Meningioma/ultrastructure , Nerve Fibers/ultrastructure , Neural Pathways/ultrastructure , Neurons/ultrastructure , Pyramidal Tracts/ultrastructure , Supratentorial Neoplasms/ultrastructure , Wallerian Degeneration/pathology
9.
Neurosci Res ; 32(4): 355-62, 1998 Dec.
Article in English | MEDLINE | ID: mdl-9950063

ABSTRACT

The widely accepted method of blood oxygenation level dependent functional magnetic resonance imaging (BOLD-fMRI) is a subtractive approach of state related analysis based on pictorial statistics, analogous to its predecessor, H2O(15) positron emission tomography (H2O(15)-PET). Although BOLD-fMRI has been shown to have several definite advantages over H2O(15)-PET, it has also been found to be much more artifact prone. This is primarily due to pixel misalignment of raw image data. Furthermore, similar to H2O(15)-PET, conventional means for pictorial analysis in BOLD-fMRI tends to be limited by the relatively low specificity of the observed activation. To overcome this limitation, we investigated a technique for BOLD-fMRI, sequential epoch analysis (SEA), on a high-field (3.0 T) system. The method allows for experimental designs comparable to neurophysiological techniques in primates and enables determination of activation of a selected cerebral cortical region of interest corresponding to a specific task. Utilizing SEA, we successfully identified a specific area within the premotor cortex which is activated complementary to the contralateral hand motion. The findings have strong implications regarding the neurological substrate responsible for the well described clinical phenomenon of physiological mirror movements in infants. The current study validated SEA BOLD-fMRI on a high-field system as a complementary method in the pictorial analysis of conventional fMRI, effectively offsetting the inherent problems of the conventional method, principally pixel misalignment and the relatively low specificity of the observed activation.


Subject(s)
Magnetic Resonance Imaging/methods , Motor Cortex/physiology , Movement/physiology , Adolescent , Adult , Brain Mapping , Humans , Magnetic Resonance Imaging/instrumentation , Reproducibility of Results
10.
Neuroreport ; 9(17): 3853-6, 1998 Dec 01.
Article in English | MEDLINE | ID: mdl-9875717

ABSTRACT

The cortical areas subserving music literacy were investigated using high-field (3 Tesla) functional magnetic resonance imaging (fMRI). The activation pattern associated specifically with music score reading was compared with that associated with reading text in a subject's primary and secondary language. While the areas of activation were predominantly identical for all three reading modalities, there were areas within the occipital cortex activated exclusively by music score reading. Grand analysis of the activation patterns of eight pianists unequivocally identified that the principal cortical area needed for music literacy is the cortex flanking the right transverse occipital sulcus (musical brain).


Subject(s)
Magnetic Resonance Imaging/methods , Music , Reading , Adult , Humans , Male , Reference Values
11.
J Neuroimaging ; 6(2): 119-21, 1996 Apr.
Article in English | MEDLINE | ID: mdl-8634486

ABSTRACT

A case of acute thalamic hematoma not detected by computed tomography (CT) but unequivocally diagnosed by magnetic resonance imaging (MRI) is presented. A 79-year-old woman presented with acute left hemiparesis. The results of CT obtained on admission as well as on the seventh hospital day were negative for a hematoma. By contrast, serial MRIs exhibited chronological changes in the relaxation properties characteristics of acute hematoma in the thalamus. The case illustrates that contrary to widespread practice, CT cannot absolutely be relied on for the detection of acute intracerebral hematoma.


Subject(s)
Cerebral Hemorrhage/diagnostic imaging , Hematoma/diagnostic imaging , Thalamic Diseases/diagnostic imaging , Tomography, X-Ray Computed , Acute Disease , Aged , Cerebral Hemorrhage/diagnosis , Diagnosis, Differential , Female , Hematoma/diagnosis , Hemiplegia/etiology , Humans , Magnetic Resonance Imaging , Thalamic Diseases/diagnosis
12.
Neuroreport ; 7(3): 726-8, 1996 Feb 29.
Article in English | MEDLINE | ID: mdl-8733731

ABSTRACT

The effects of diabetes mellitus on the kinetic constants of aldose reductase and sorbitol dehydrogenase in rat brain were investigated non-invasively in vivo using the 3-fluoro-3-deoxy-D-glucose (3-FDG) 19-fluorine (19F) nuclear magnetic resonance (NMR) method. While forward flux or both aldose reductase and sorbitol dehydrogenase (k1 and k2) were significantly increased, there was no corresponding increase in reverse flux (k3 and k4), and leakage of fructose (k5) was negligible. These findings indicate that the enzymatic kinetics of aldose reductase sorbitol (ARS) in diabetic brain undergo alteration favoring intracellular sorbitol and fructose accumulation, the frequently implicated biochemical basis of diabetic complications.


Subject(s)
Aldehyde Reductase/metabolism , Diabetes Mellitus, Experimental/metabolism , L-Iditol 2-Dehydrogenase/metabolism , Animals , Deoxyglucose/analogs & derivatives , Deoxyglucose/pharmacology , Fluorine Radioisotopes , Fluorodeoxyglucose F18 , Kinetics , Magnetic Resonance Spectroscopy , Rats , Rats, Sprague-Dawley
13.
J Neurosurg ; 83(6): 1023-8, 1995 Dec.
Article in English | MEDLINE | ID: mdl-7490616

ABSTRACT

The recent development of magnetic resonance (MR) axonography, which uses three-dimensional anisotropy contrast (3DAC), a new algorithm for the treatment of an apparent diffusion tensor, has provided an unprecedented opportunity for visualizing the anatomical details of the spinal cord in live animals. In this study, the authors investigated the sensitivity of the 3DAC method in detecting pathological conditions by obtaining chronological MR axonography of the rat spinal cord immediately after induction of cardiac arrest. The results clearly demonstrated that 3DAC is highly sensitive to any perturbation of physiological conditions. Trichromatic coefficient analyses indicated postmortem changes observed pictorially are indeed due to loss of anisotropy. The study further indicated the presence of at least two independent factors responsible for observed physiological anisotropy. Considering its rather simple implementation process and high anatomical resolution as well as its sensitivity to pathological alteration, MR axonography based on the 3DAC method appears to be the ideal noninvasive imaging technique for assessment of the spinal cord in biomedicine.


Subject(s)
Postmortem Changes , Spinal Cord/pathology , Animals , Anisotropy , Axons/pathology , Death, Sudden, Cardiac/pathology , Diffusion , Image Processing, Computer-Assisted , Magnetic Resonance Imaging , Mathematics , Rats , Rats, Sprague-Dawley , Spinal Cord/physiopathology , Time Factors
14.
Life Sci ; 56(14): 1201-6, 1995.
Article in English | MEDLINE | ID: mdl-7475897

ABSTRACT

The potential neuroprotective effects of guanidinoethane sulfate (GES) on delayed neuronal death of hippocampal CA1 neurons were investigated using a gerbil model of forebrain ischemia. Neuronal densities of CA1 neurons in the saline control group (255.1 +/- 11.7 cells/mm) and guanidinoethane sulfate pretreated control group (249.0 +/- 9.4 cells/mm) showed no significant differences. By contrast, in animals subjected to ischemia, CA1 neurons of the guanidinoethane sulfate pretreated group showed a significantly higher number of surviving neurons (61.1 +/- 55.11 cells/mm) compared to the saline group (17.75 +/- 12.73 cells/mm) (p < 0.05, t-test). The study indicated that although partial, guanidinoethane sulfate is neuroprotective towards gerbil hippocampal CA1 neurons against ischemic insult.


Subject(s)
Brain Ischemia/pathology , Cell Death/drug effects , Hippocampus/pathology , Neurons/drug effects , Neuroprotective Agents/pharmacology , Taurine/analogs & derivatives , Animals , Brain Ischemia/drug therapy , Gerbillinae , Male , Neurons/physiology , Taurine/pharmacology , Taurine/therapeutic use
15.
Neuroreport ; 5(16): 2053-6, 1994 Oct 27.
Article in English | MEDLINE | ID: mdl-7865743

ABSTRACT

In spite of dramatic advancement in biomedical imaging technologies, non-invasive visualization of anatomic detail of the spinal cord has remained a major challenge. Here, a novel color-coded contrast method for magnetic resonance imaging (MRI) which provides superb resolution of the spinal cord in live animals, comparable to that of histological preparations, is described. The method, referred to here as three dimensional anisotropy (3DAC) contrast MRI, displays cross-sectional images in the full visible color spectrum, encoding directional information regarding intravoxel anisotropic water motion in space. Since neuronal fibers, especially axons, possess significantly higher intravoxel anisotropic water motion compared with other elements in the nervous system, 3DAC is highly sensitive to axonal direction and density. Axonography of the spinal cord of rats obtained using this technique showed anatomic detail at a resolution hitherto unobtainable in live animals.


Subject(s)
Axons/ultrastructure , Magnetic Resonance Imaging/methods , Spinal Cord/ultrastructure , Animals , Anisotropy , Color , Diffusion , Rats , Rats, Sprague-Dawley
16.
Brain Res Dev Brain Res ; 80(1-2): 121-6, 1994 Jul 15.
Article in English | MEDLINE | ID: mdl-7955336

ABSTRACT

Maturational changes in intracellular brain phosphocreatine (PCr) transport were investigated using 31P-nuclear magnetic resonance diffusion spectroscopy. The diffusivities of PCr showed significant maturational facilitation in rat brain in vivo. Physicochemical analysis of the cytosol microenvironment as a multicomponent solution, where one of the components is a dilute polymer, indicated that the observed developmental facilitation of PCr diffusivity is likely to be due to a decline in the concentration of the free amino acid taurine. Changes in the concentrations of biopolymers (i.e., proteins or lipids) have only little effect, if any, on PCr diffusivity. PCr diffusivity values of rat brain measured in vivo showed excellent quantitative agreement with the predicted values estimated using a model for multicomponent diffusion. The study confirmed that the taurine/N-acetylaspartate exchange observed during postnatal development of rat brain plays a major, it not unique, role in maturational facilitation of intracellular high-energy phosphate transport.


Subject(s)
Brain/growth & development , Cytosol/metabolism , Phosphocreatine/pharmacokinetics , Albumins/chemistry , Animals , Aspartic Acid/analogs & derivatives , Aspartic Acid/pharmacology , Chemical Phenomena , Chemistry, Physical , Diffusion , Magnetic Resonance Spectroscopy , Models, Biological , Phosphocreatine/chemistry , Rats , Rats, Sprague-Dawley , Taurine/metabolism , Viscosity
17.
Neuroreport ; 4(8): 1035-8, 1993 Aug.
Article in English | MEDLINE | ID: mdl-8241459

ABSTRACT

A new category of agents, brain pH alkaline shifters, is described. Using the prototype agent, guanidinoethane sulfate (GES), the actual alkaline shift in pH was demonstrated in adult mice brain by 31-phosphorus (31P) nuclear magnetic resonance (NMR) in vivo spectroscopy. This alkaline shift was also shown to effectively reduce the extent of brain intracellular lactic acidosis brought about by anoxic insult. These findings support the notion that a pH alkaline shift may protect the brain against the deleterious effects of lactic acidosis. Since higher pH has been shown to significantly reduce beta-amyloid deposition, alkaline shifters may also have therapeutic potential in Alzheimer's disease.


Subject(s)
Alkalies/metabolism , Brain/metabolism , Taurine/analogs & derivatives , Animals , Hydrogen-Ion Concentration , Hypoxia, Brain/metabolism , Lactates/metabolism , Male , Mice , Mice, Inbred Strains , Taurine/metabolism , Taurine/pharmacology
18.
Magn Reson Med ; 29(4): 543-5, 1993 Apr.
Article in English | MEDLINE | ID: mdl-8464370

ABSTRACT

Noninvasive investigation of aldose reductase activities in rat testis was performed using 3-fluoro-3-deoxy-D-glucose (3-FDG) and nuclear magnetic resonance (NMR) spectroscopy/imaging. Quantitative determination of testis aldose reductase activities, expressed as the sorbitol index, showed a value similar to that of brain. Sorbitol imaging demonstrated aldose reductase activities in testis to be confined primarily to the central region of this organ. The 3-FDG 19F NMR method appears to have clinical potential in the evaluation of testicular function, especially that of spermatogenesis, noninvasively.


Subject(s)
Aldehyde Reductase/metabolism , Deoxyglucose/analogs & derivatives , Magnetic Resonance Imaging , Magnetic Resonance Spectroscopy , Testis/enzymology , Animals , Fluorine Radioisotopes , Male , Rats , Rats, Sprague-Dawley , Sorbitol , Testis/anatomy & histology
19.
Magn Reson Med ; 29(1): 122-4, 1993 Jan.
Article in English | MEDLINE | ID: mdl-8419732

ABSTRACT

31-Phosphorus (31P) nuclear magnetic resonance (NMR) spectroscopy of fetal brain in utero was obtained entirely noninvasively in rat utilizing image selected in vivo spectroscopy (ISIS). The results were in excellent agreement with the data obtained using the surface coil method in the late stage fetus, namely, high phosphomonoester (PME), low phosphocreatine (PCr), and high intracellular pH. Localized spectroscopy provides unprecedented opportunities for the investigation of fetal brain metabolism in utero.


Subject(s)
Brain/metabolism , Fetus/metabolism , Magnetic Resonance Spectroscopy , Animals , Phosphates/chemistry , Rats , Rats, Sprague-Dawley
20.
Neurosci Res ; 15(1-2): 115-23, 1992 Oct.
Article in English | MEDLINE | ID: mdl-1336578

ABSTRACT

A quantitative analysis of taurine effect (facilitation of acid handling capacity of brain in response to anoxia/hypoxia by high levels of cytosolic taurine) was performed utilizing multinuclear (1H, 31P) in vivo nuclear magnetic resonance (NMR) spectroscopy and in vitro titration analysis. Taurine effects observed in vivo showed excellent quantitative agreement with the predicted values estimated based on brain taurine levels. The study confirmed that high levels of cytosolic taurine indeed facilitate acid buffering capacity of brain and this taurine effect can be readily explained by the physical, and need not involve metabolic, properties of taurine. Taurine appears to be a key component of the brain cytosol system in the fetus.


Subject(s)
Acidosis, Lactic/metabolism , Brain Chemistry/drug effects , Taurine/pharmacology , Animals , Blood Glucose/metabolism , Chromatography, High Pressure Liquid , Female , Hydrogen-Ion Concentration , Lactates/blood , Magnetic Resonance Spectroscopy , Phosphocreatine/metabolism , Pregnancy , Rats , Rats, Sprague-Dawley , Taurine/metabolism
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