Constraints on Gaussian Error Channels and Measurements for Quantum Communication.

Joint Gaussian measurements of two quantum systems are important for quantum communication between remote parties and are often used in continuous-variable teleportation or entanglement-swapping protocols. Many of the errors in real-world implementations can be modeled by independent Gaussian error channels acting prior to measurement. In this work we study independent single-mode Gaussian error channels on two modes A and B that take place prior to a joint Gaussian measurement. We determine the set of pairs of such channels that render all Gaussian measurements separable, and therefore unsuitable for entanglement swapping or teleportation of arbitrary input states. For example, if the error channels are loss with parameters lA,lB followed by added noise with parameters nA,nB then all Gaussian measurements are separable if and only if lA+lB+nA+nB≥1.

NUCLEAR FACTOR-ERYTHROID-2-RELATED FACTOR REGULATES SYSTEMIC AND PULMONARY BARRIER FUNCTION AND IMMUNE PROGRAMMING AFTER BURN AND INHALATION INJURY.

ABSTRACT: Major burn injury is associated with systemic hyperinflammatory and oxidative stresses that encompass the wound, vascular, and pulmonary systems that contribute to complications and poor outcomes. These stresses are exacerbated if there is a combined burn and inhalation (B+I) injury, which leads to increases in morbidity and mortality. Nuclear factor-erythroid-2-related factor (NRF2) is a transcription factor that functions to maintain homeostasis during stress, in part by modulating inflammation and oxidative injury. We hypothesized that the NRF2-mediated homeostasis after burn alone and combined B-I injury is insufficient, but that pharmacological activation of the NRF2 pathway has the potential to reduce/reverse acute hyper inflammatory responses. We found that, after burn and B+I injury, Nrf2 -/- mice have higher mortality and exhibit greater pulmonary edema, vascular permeability, and exacerbated pulmonary and systemic proinflammatory responses compared with injured wild-type (WT) controls. Transcriptome analysis of lung tissue revealed specific Nrf2 -dependent dysregulated immune pathways after injury. In WT mice, we observed that B+I injury induces cytosolic, but not nuclear, accumulation of NRF2 protein in the lung microenvironment compared with sham-injured controls. Bardoxolone methyl (CDDO-Me)-containing microparticles (CDDO-MPs) were developed that allow for dilution in saline and stable release of CDDO-Me. When delivered intraperitoneally into mice 1 hour after B+I injury, CDDO-MPs significantly reduced mortality and cytokine dysfunction compared with untreated B-I animals. These data implicate the role of NRF2 regulation of pulmonary and systemic immune dysfunction after burn and B+I injury, and also a deficiency in controlling immune dysregulation. Selectively activating the NRF2 pathway may improve clinical outcomes in burn and B+I patients.

High-Fidelity Indirect Readout of Trapped-Ion Hyperfine Qubits.

We propose and demonstrate a protocol for high-fidelity indirect readout of trapped ion hyperfine qubits, where the state of a ^{9}Be^{+} qubit ion is mapped to a ^{25}Mg^{+} readout ion using laser-driven Raman transitions. By partitioning the ^{9}Be^{+} ground-state hyperfine manifold into two subspaces representing the two qubit states and choosing appropriate laser parameters, the protocol can be made robust to spontaneous photon scattering errors on the Raman transitions, enabling repetition for increased readout fidelity. We demonstrate combined readout and back-action errors for the two subspaces of 1.2_{-0.6}^{+1.1}×10^{-4} and 0_{-0}^{+1.9}×10^{-5} with 68% confidence while avoiding decoherence of spectator qubits due to stray resonant light that is inherent to direct fluorescence detection.

Entanglement Thresholds of Doubly Parametric Quantum Transducers.

Doubly parametric quantum transducers, such as electro-optomechanical devices, show promise for providing the critical link between quantum information encoded in highly disparate frequencies such as in the optical and microwave domains. This technology would enable long-distance networking of superconducting quantum computers. Rapid experimental progress has resulted in impressive reductions in decoherence from mechanisms such as thermal noise, loss, and limited cooperativities. However, the fundamental requirements on transducer parameters necessary to achieve quantum operation have yet to be characterized. In this work we find simple, protocol-independent expressions for the necessary and sufficient conditions under which doubly parametric transducers in the resolved-sideband, steady-state limit are capable of entangling optical and microwave modes. Our analysis treats the transducer as a two-mode bosonic Gaussian channel capable of both beamsplitter-type and two-mode squeezing-type interactions between optical and microwave modes. For the beamsplitter-type interaction, we find parameter thresholds that distinguish regions of the channel's separability, capacity for bound entanglement, and capacity for distillable entanglement. By contrast, the two-mode squeezing-type interaction always produces distillable entanglement with no restrictions on temperature, cooperativities, or losses. Counterintuitively, for both interactions, we find that achieving quantum operation does not require either a quantum cooperativity exceeding one, or ground-state cooling of the mediating mode. Finally, we discuss where two state-of-the-art implementations are relative to these thresholds and show that current devices operating in either mode of operation are in principle capable of entangling optical and microwave modes.

Direct observation of deterministic macroscopic entanglement.

Quantum entanglement of mechanical systems emerges when distinct objects move with such a high degree of correlation that they can no longer be described separately. Although quantum mechanics presumably applies to objects of all sizes, directly observing entanglement becomes challenging as masses increase, requiring measurement and control with a vanishingly small error. Here, using pulsed electromechanics, we deterministically entangle two mechanical drumheads with masses of 70 picograms. Through nearly quantum-limited measurements of the position and momentum quadratures of both drums, we perform quantum state tomography and thereby directly observe entanglement. Such entangled macroscopic systems are poised to serve in fundamental tests of quantum mechanics, enable sensing beyond the standard quantum limit, and function as long-lived nodes of future quantum networks.