ABSTRACT
PURPOSE: To investigate whether subclinical ciliochoroidal effusion and resulting asymptomatic angle narrowing occurs in patients taking topiramate, by ultrasound biomicroscopy (UBM). METHODS: Chinese patients aged 18-75 years for whom topiramate was indicated were recruited. Examinations including UBM were performed before and 4 weeks after commencement of topiramate. RESULTS: In this pilot of 20 eyes of 20 patients, there were no statistically significant changes in the angle parameters noted on gonioscopy or UBM, including anterior chamber depth, angle-opening distance at 500 mum, trabecular ciliary process distance, trabecular-iris angle, and scleral thickness. CONCLUSION: Short-term use of topiramate does not induce asymptomatic angle narrowing.
Subject(s)
Anterior Eye Segment/drug effects , Fructose/analogs & derivatives , Neuroprotective Agents/adverse effects , Adult , Anterior Eye Segment/diagnostic imaging , Anterior Eye Segment/pathology , Asian People , China , Female , Fructose/adverse effects , Humans , Intraocular Pressure/drug effects , Male , Microscopy, Acoustic , Middle Aged , Pilot Projects , Prospective Studies , Topiramate , Visual Acuity/drug effects , Young AdultABSTRACT
AIM: To document any correlation between previous acute angle-closure attack and the extent of synechial angle closure in chronic primary angle-closure glaucoma (PACG) patients. METHODS: Consecutive cases of chronic PACG with patent peripheral iridotomy had gonioscopy performed. The extents of synechial angle closure of those chronic PACG eyes with previous documented acute angle-closure attack were compared to those eyes without such a history. RESULTS: A total of 102 chronic PACG eyes of 102 patients were recruited. Twenty-seven eyes (26.5%) had a previous documented acute angle closure, while 75 eyes (73.5%) did not. The mean extent of synechial angle closure +/-1 SD was 307+/-68 degrees (range, 150-360 degrees) in those chronic PACG eyes with a history of previous acute angle closure, compared to 266+/-89 degrees (range, 90-360 degrees) in those chronic PACG eyes without such a history (P=0.03, Student's t-test). There were no statistically significant differences between the two groups in age, LogMAR visual acuity, intraocular pressure (IOP), number of glaucoma eye drops, vertical cup-to-disk ratio, mean deviation or pattern SD in Humphrey automated perimetry, and anterior chamber depth (P>0.05). CONCLUSION: Previous acute angle-closure attack correlated with more extensive synechial angle closure in chronic PACG patients in this study.
