ABSTRACT
PURPOSE: To estimate the risk of radiation-induced changes in the lung before single-dose treatment (stereotactic body radiation therapy [SBRT]) of lung cancer, the quantitative dose-response and volume-response relations must be known. METHODS AND MATERIALS: A total of 64 patients treated for non-small-cell lung cancer with single doses of 20-30 Gy were classified according to the occurrence or nonoccurrence of perifocal changes in the lung detected by CT. Patients without toxic events in the lung were required to have >or=6 months of follow-up. The mean dose (D(mean)) in the ipsilateral lung and the volume receiving >7 or 10 Gy (V7 and V10, respectively) were used to calculate the dose-response and volume-response curves. The predictive value of additional variables was also investigated. RESULTS: Of the 64 patients, 83% exhibited the selected endpoint. The tolerance values at a 50% probability of toxic events were 1.2 +/- 0.7 Gy for the D(mean) and 5.8 +/- 3.0% and 3.1 +/- 2.0% for V7 and V10, respectively. A nonsignificant shift to higher doses was seen for the dose-response curve for the upper compared with the lower part of the lung. CONCLUSION: The D(mean), V7, and V10 can be used to predict the risk of lung toxicity after SBRT treatment of non-small-cell lung cancer. Because of the lack of patients with low prescribed doses, however, the related uncertainty of this prediction is still relatively large. The D(mean), V7, and V10 are equally well suited. The additional investigated variables did not provide significant advantages. The lower part of the lung appears to be more radiosensitive than the upper.
Subject(s)
Carcinoma, Non-Small-Cell Lung/radiotherapy , Lung Neoplasms/radiotherapy , Lung/radiation effects , Adult , Aged , Aged, 80 and over , Dose-Response Relationship, Radiation , Female , Humans , Male , Middle Aged , Radiation Injuries , Radiation Tolerance , Radiotherapy Dosage , Tomography, X-Ray ComputedABSTRACT
Complex dose-delivery techniques, as currently applied in intensity-modulated radiation therapy (IMRT), require a highly efficient treatment-verification process. The present paper deals with the problem of the scatter correction for therapy verification by use of portal images obtained by an electronic portal imaging device (EPID) based on amorphous silicon. It also presents an iterative method for the scatter correction of portal images based on Monte Carlo-generated scatter kernels. First applications of this iterative scatter-correction method for the verification of intensity-modulated treatments are discussed on the basis of MVCT- and dose reconstruction. Several experiments with homogeneous and anthropomorphic phantoms were performed in order to validate the scatter correction method and to investigate the precision and relevance in view of its clinical applicability. It is shown that the devised concept of scatter correction significantly improves the results of MVCT- and dose reconstruction models, which is in turn essential for an exact online IMRT verification.
