ABSTRACT
OBJECTIVES: To compare the sensitivity of MRI to detect colorectal cancer liver metastases (CRLM) after ingestion of manganese-based contrast agent (CMC-001) with that of a comprehensive intravenous gadobenate dimeglumine protocol, and to assess the safety and acceptability of oral manganese. METHODS: 20 patients suspected of having 1-6 CRLM were included prospectively in this randomised cross-over study. Liver MRI was performed with a one-week interval at 1.5 T and included T1-w VIBE and T2-HASTE, before and after administration of 1.6 g CMC-001 or 0.1 mmol/kg gadobenate dimeglumine. The metastasis-to-liver signal intensity (SI) ratio was calculated. Standard of reference was histopathology after surgery, or combination of other imaging studies and/or follow up. Adverse events (AE) and clinicolaboratory tests were monitored. RESULTS: Of 44 metastases, 41 were detected after CMC-001 (93%) and 42 after gadobenate dimeglumine (95%). Fifteen false-positive lesions were found after CMC-001 and 2 after gadobenate dimeglumine. The metastasis-to-liver SI ratio was significantly higher after CMC-001 than after gadobenate dimeglumine (0.51 and 0.21 respectively, P < 0.0001). More AE occurred after manganese compared to gadobenate dimeglumine. CONCLUSIONS: CMC-001 is as sensitive as an extensive intravenous gadobenate dimeglumine protocol in detecting CRLM. It was relatively well tolerated but had higher rates of gastrointestinal AE. KEY POINTS: ⢠Liver MRI after ingestion of manganese is highly sensitive for detecting metastases ⢠High false-positive rate necessitates further evaluation, in some cases ⢠The MR examination time is short ⢠Oral ingestion of manganese seems safe and relatively well tolerated by patients ⢠Manganese compounds may be useful for liver metastasis surveillance after colorectal cancer.
Subject(s)
Colorectal Neoplasms/pathology , Contrast Media/administration & dosage , Liver Neoplasms/secondary , Magnetic Resonance Imaging/methods , Manganese/administration & dosage , Meglumine/analogs & derivatives , Organometallic Compounds/administration & dosage , Administration, Oral , Aged , Colorectal Neoplasms/diagnostic imaging , Cross-Over Studies , Female , Humans , Injections, Intravenous , Liver Neoplasms/diagnostic imaging , Male , Meglumine/administration & dosage , Middle Aged , Phospholipids/administration & dosage , Predictive Value of Tests , Prospective Studies , Sensitivity and Specificity , Statistics, Nonparametric , Sulfur Hexafluoride/administration & dosage , UltrasonographyABSTRACT
We report two patients with uncommon Gilbert's syndrome with severe unconjugated hyperbilirubinemia which was reduced from 200 to 60-90 micromol/L by long-term administration of rifampicin. Hepatic induction of bilirubin-glucuronosyltransferase was suggested by increased relative amounts of conjugated serum bilirubin. This molecular mechanism was confirmed in primary cultures of human hepatocytes.
