ABSTRACT
Oxidative stress has long been recognized to play an important role in the pathogenesis of chronic obstructive pulmonary disease (COPD) and aging, initiating oxidative damage of biomolecules. In this study the development of imbalances in the system of lipid peroxidation and increase the level of the marker of oxidative damage to DNA - 8-hydroxy-deoxyguanosine (8-ÐÐdG) in patients with COPD and healthy individuals. Evaluation of the relationship between the parameters of the system of lipid peroxidation and the level of 8-ÐÐdG allowed to drill down to different oxidative mechanisms in the pathogenesis of COPD in patients of middle or old age.
Subject(s)
DNA Damage/physiology , Deoxyguanosine/analogs & derivatives , Pulmonary Disease, Chronic Obstructive/metabolism , 8-Hydroxy-2'-Deoxyguanosine , Age Factors , Aged , Biomarkers/analysis , Biomarkers/metabolism , Deoxyguanosine/analysis , Deoxyguanosine/metabolism , Female , Humans , Lipid Peroxidation , Male , Middle Aged , Oxidative Stress/physiology , Statistics as TopicABSTRACT
The aging process is characterized by progressive limitation of the adaptive capacities of the organism determining the level of human health. The analysis of the functioning systems involved in the adaptation of structural and functional modifications of the-body, is one of the important areas of the research in the medicine. Investigation of mechanisms of adaptive reactions is possible on the basis of an assessment of the correlation of the relationship of homeostatic functions of various body systems. A number of clinical studies during the last decades showed ontogenetic variability of the lipid spectrum of cell membranes, immune, lipid peroxidation-antioxidant protection systems, blood system, involved in the adaptation of the underlying cellular and molecular levels. The relationship of some homeostatic systems during physiological aging was investigated. We found the increase in the amount of intersystem relationship, the power of intersystem and intrasystem relationship. The observed complexity of structural and functional interactions, of homeostatic systems of the aging body indicates age-dependent cooperative systems, aimed at preserving the relationships between them, and a smaller balance of adaptive reactions in the elderly. The study of the nature of intersystem and intrasystem integrations with age aspects allowed showing the adaptive strategy of an aging organism, aimed at preserving its functional integrity.
