[The effect of administration of beta-carotene in an oil solution on its blood serum level and antioxidant status of patients with duodenal ulcer and erosive gastritis]. / Vliianie prema maslianogo rastvora beta-karotina na ego uroven' v syvorotke krovi i antioksidantnyi status bol'nykh iazvoi dvenadtsatiperstnoi kishki i érozivnym gastritom.

Adequately good consumption of beta-carotene was observed in patients with duodenal ulcer and erosive gastritis after daily treatment with 18 mg of the carotinoid used as 0.1% oil solution: concentration of beta-carotene was increased approximately 3-fold in blood serum of these patients. Concentration of retinol was not increased in blood serum after treatment with beta-carotene, thus indicating that the drug treatment was not dangerous. Treatment with beta-carotene led to improvement in the state of the antioxidative system of these patients as resistance of erythrocytes to peroxide hydrolysis was increased while content of malonic dialdehyde was decreased in blood serum. The carotene treatment contributed to arresting pain syndrome in patients with ulcers, to cicatrization of ulcers and to disappearance of gastric mucosal membrane erosion.

[Lipid peroxidation upon the use of omega-3 polyunsaturated fatty acids in the treatment of hypertension and ischemic heart disease]. / Perekisnoe okislenie lipidov pri ispol'zovanii v lechenii gipertonii i ishemicheskoi bolezni serdtsa polinenasyshchennykh zhirnykh kislot semeistva omega3.

Anti-atherosclerotic diet containing 10 or 20 g of ichthyenic oil, used for treatment of 29 patients with cardiovascular diseases, caused an increase in content of polyunsaturated omega 3 fatty acids species in the patients erythrocyte membranes; this pattern may be used as a sensitive criterion of evaluation of the diet fatty component effect. Despite an increase of oxidation potential substrates in tissues, elevation of malonyl dialdehyde in blood plasma and hemolysis of erythrocytes in presence of H2O2 were not observed. This suggests absence of lipid peroxidation induction in adequate consumption of antioxidants.

[The vitamin E allowance of rats on different combinations of sunflower and soybean oils in their diets]. / Obespechennost' krys vitaminom E pri razlichnykh sochetaniiakh podsolnechnogo i soevogo masel v ikh ratsionakh.

Soybean oil and its combinations with sunflower oil, as 1:1 and 1:3, were used in the rations intended for rats. As it is evidenced by the data on the content of tocopherol in the tissues, malonic dialdehide in the liver, diene conjugates in the liver and red blood cells, and red blood cell resistance, the fatty products used in the rations sufficiently provided the animals with antioxidants. The role of tocopherol isomers and phosphatides, as synergists of antioxidants in varying combinations of soybean and sunflower oils, formed for simultaneous intake of linoleic and linolenic acids with the ration, has been analyzed.

[Effect of diets of different isomer composition of fatty acids on the blood vessel wall, blood lipids and platelet aggregation]. / Vliianie ratsionov s razlichnym izomernym sostavom zhirnykh kislot na stenku krovenosnykh sosudov, lipidy krovi i agregatsiiu trombotsitov.

It was established in rat experiments that prolonged (4.5 months) use of the diet with a high content of spatial (trans-) and positional isomers of fatty acids exerted an adverse effect on the laboratory animals. They showed the impairment of the hemostasis integrity; namely of the walls of blood vessels (aorta, intraorgan arteries of the heart and kidneys), blood lipids, fatty acid composition and aggregation properties of platelets. The animals developed alterations similar to those occurring with the use of the diets rich in saturated fatty acids. The vessels manifested dystrophic alterations of elasticity and smooth muscle cells, whereas blood an increase in the content of atherogenic lipoproteins associated with a high content of total lipids and cholesterol. The ADP-induced enhancement of platelet aggregation was observed in experiments in vitro.

[Effect of vitamin E deficiency and of qualitatively varying dietary fats on the structure of the aorta and of the heart and kidney arteries in rats]. / Vliianie nedostatochnosti vitamin E i kachestvenno razlichnykh zhirov pishchi na struktury aorty i arterii serdtsa i pochek u krys.

Rats kept for 8 months on vitamin E deficient diet or given butter in an amount of 50 % of the diet caloric value developed similar morphological changes in aortal walls and in intraorgan arteries of the heart and kidneys. These changes marked by derangement of the elastic base of the vascular wall were most pronounced in rats kept on E-avitaminosis diet. In these animals changes in vascular elasticity developed in the presence of the intima edema, occasionally, of the media, formation of the thickening of the vascular wall, appearance of calcinosis areas in it. As a rule, changes in coronary vessels were associated with myocardial structure impairment manifesting in the form of foci of necrosis in the muscle layer, in reparative cellular reaction and foci of substitution sclerosis.

[Effect of the quality characteristics of the fatty component of the diet on the fatty acid makeup of the erythrocytic and thrombocytic membranes in healthy persons]. / Vliianie kachestvennykh osobennostei zhirovogo komponenta ratsiona na zhirnokislotnyi sostav membran éritrotsitov i trombotsitov u zdorovykh liudei.

Practically healthy males received rations in which principal sources of fat in the descending order were butter, sunflower and mustard oil. The influence of qualitative properties of the ration's fat on the lipids metabolism in the plasma and the coefficient of the metabolization effectiveness of essential fatty acids (CEM) of the food into the membranes lipids was studied. The CEM was calculated by studying the fatty acids composition of the erythrocytes and thrombocytes stroma. Inclusion in the ration of butter alone, raised the cholesterol level, a fall of the plasma phospholipids level and a significant drop of the CEM. Substitution of sunflower oil for butter led to normalization of these figures. Mustard oil had no effect. Changes in the CEM of the erythrocytes stroma proceeded slowly, significant differences having been discovered only after 6 weeks of the butter consumption. The thrombocytes CEM changed quickly, a stable fatty acids composition of thrombocytes with this ration being established by the end of the 2nd week. The qualitative properties of the ration's fat exercise a sufficiently strong influence on the effective metabolization of fatty acids in the food into the lipid structures of the erythrocytes and thrombocytes membranes in a healthy subject, it being characterized by the CEM changes.