ABSTRACT
To study intestinal colonization by OXA-48-producing Klebsiella pneumoniae (KpO48) after hospital discharge, stool samples from 22 previously colonized subjects were collected. Time from discharge was 33-611 days, without readmissions. Eight subjects (36%) were identified as blaOXA-48 gene carriers. In all of them the hospital-acquired strain of KpO48 had been lost, and the gene was harboured by other strains of K. pneumoniae, Klebsiella oxytoca and/or Escherichia coli. Our findings show intestinal persistence for several months of a plasmid harbouring the OXA-48 carbapenemase gene in a significant proportion of individuals in the absence of antibiotic treatment.
Subject(s)
Carrier State/epidemiology , Enterobacteriaceae Infections/epidemiology , Escherichia coli/isolation & purification , Feces/microbiology , Klebsiella oxytoca/isolation & purification , Plasmids/analysis , beta-Lactamases/genetics , Adolescent , Adult , Aged , Aged, 80 and over , Bacterial Proteins , Carrier State/microbiology , Enterobacteriaceae Infections/microbiology , Escherichia coli/enzymology , Escherichia coli/genetics , Escherichia coli Infections , Female , Genes , Hospitals , Humans , Klebsiella oxytoca/enzymology , Klebsiella oxytoca/genetics , Klebsiella pneumoniae/enzymology , Klebsiella pneumoniae/genetics , Klebsiella pneumoniae/isolation & purification , Male , Middle Aged , Pilot Projects , Time Factors , Young AdultSubject(s)
Klebsiella Infections/microbiology , Klebsiella pneumoniae/enzymology , Klebsiella pneumoniae/isolation & purification , beta-Lactamases/metabolism , Aged , Anti-Bacterial Agents/pharmacology , Bolivia , Genotype , Hospitals , Humans , Klebsiella pneumoniae/classification , Klebsiella pneumoniae/genetics , Microbial Sensitivity Tests , Multilocus Sequence TypingABSTRACT
Introducción: el Streptococcus pyogenes (S. pyogenes) es una etiología poco habitual de meningitis bacteriana a pesar de ser un germen que frecuentemente produce infecciones en otras localizaciones en la edad pediátrica. Material y métodos: se revisaron los casos de bacteriemia por S. pyogenes y los factores de riesgo asociados en la base de datos del Servicio de Microbiología del Hospital Universitario La Paz desde junio de 2002 a junio de 2012. Resultados: únicamente se encontró un caso de bacteremia por S. pyogenes asociado a meningitis, que se describe en este artículo. Conclusiones: a pesar de su baja incidencia, se debe tener en cuenta el S. pyogenes en el diagnóstico diferencial de meningitis bacterianas, especialmente en pacientes con factores de riesgo asociados (AU)
Introduction: Streptococcus pyogenes (S. pyogenes) is a rare cause of meningitis despite being a common source of pediatric infections in other sites. Material and methods: A search was performed of the pediatric patients with S. pyogenes bacteremia in the microbiology database of the Hospital Infantil La Paz from June 2002 until June 2012. Results: A single case of S. pyogenes meningitis was found and is reported in this article. Conclusions: Despite its low incidence, S. pyogenes should be considered in the differential diagnosis of meningitis, particularly in patients with associated risk factors (AU)
