1.
Am J Clin Oncol
; 13(6): 477-9, 1990 Dec.
Article
in English
| MEDLINE
| ID: mdl-2239802
ABSTRACT
One hundred and twenty-four patients with a diagnosis of metastatic gastrointestinal cancer and no prior therapy were included in this clinical study of carmofur monotherapy, 300-500 mg/m2 daily for 6 weeks. For the 115 evaluable patients, the response rates were 19.4% in gastric cancer, 27.2% in cancer of mobile colon, and 12.5% in rectal cancer. No objective responses were seen in 38 patients with pancreatic cancer, although the disease of 13 of these patients has remained stable over a considerably long period of follow-up. The toxicity profile was interesting; the main adverse effects were urinary bladder symptoms and flush. Hematologic toxicity was minimal. The treatment proved to be safe and could be used for outpatients.
Subject(s)
Antineoplastic Agents/therapeutic use , Colonic Neoplasms/drug therapy , Fluorouracil/analogs & derivatives , Pancreatic Neoplasms/drug therapy , Rectal Neoplasms/drug therapy , Stomach Neoplasms/drug therapy , Administration, Oral , Adolescent , Adult , Aged , Antineoplastic Agents/administration & dosage , Antineoplastic Agents/adverse effects , Drug Administration Schedule , Female , Fluorouracil/administration & dosage , Fluorouracil/adverse effects , Fluorouracil/therapeutic use , Humans , Male , Middle Aged
2.
Duodecim
; 90(19): 1295-302, 1974.
Article
in Finnish
| MEDLINE
| ID: mdl-4426278
Subject(s)
Death, Sudden , Infant , Asphyxia/mortality , Female , Finland , Humans , Hypersensitivity/mortality , Infant, Newborn , Male , Respiratory Tract Infections/mortality , Social Class , Vomiting
3.
Comp Gen Pharmacol
; 1(2): 152-4, 1970 Jun.
Article
in English
| MEDLINE
| ID: mdl-5527551