ABSTRACT
Introducción: Los trastornos musculoesqueléticos (TME) representan un importante problema de salud entre los trabajadores de países industrializados siendo la principal causa de incapacidad temporal (IT) y permanente (IP) en nuestro país. En la industria de la alimentación se llevan a cabo tareas que implican movimientos repetitivos, posturas forzadas y estáticas derivando en patologías de miembro superior y columna. Este tipo de labores pueden originar patologías tendinosas entre las que se encuentra la epicondilitis, desencadenada por movimientos repetitivos de extensión de la muñeca y prono-supinación del antebrazo. Objetivos: Establecer la prevalencia de expedientes de IP presentados por epicondilitis en trabajadores de la industria alimentaria. Estratificar los expedientes de IP presentados por los trabajadores de la industria alimentaria, tanto los expedientes por epicondilitis como los expedientes por el resto de TME, en función de: edad, género, Comunidades Autónomas (CCAA), código CIE-9, quién inicia el expediente, calificación, resolución, tipo de contingencia, régimen de cotización y clasificación CNO-11. Analizar las variables contingencia y la calificación respecto al resto de variables. Identificar sector susceptible de implementar mejoras en la actividad preventiva. Método: El presente estudio descriptivo transversal se llevará a cabo mediante la recogida de información a través de la base de datos Alfa (Automatización del Procedimiento de Gestión de Prestaciones) del Instituto Nacional de la Seguridad Social (INSS). Se utilizará el programa estadístico R Core Team 2021, versión 4.0.5. para el análisis descriptivo de los datos. (AU)
Introduction: Musculoskeletal disorders (MSDs) represent a major health problem among workers in industrialized countries and are the main cause of temporary and permanent work disability in our country. In the food industry, tasks that involve repetitive movements, forced and static postures are carried out, resulting in upper limb and spine pathologies. This type of work can cause tendon pathologies, among which is epicondylitis, triggered by repetitive movements of wrist extension and prono-supination of the forearm. Objectives: To establish the prevalence of Permanent Disability files filed for epicondylitis presented in food industry workers. To stratify the Permanent Disability files presented by food industry workers, both the files for epicondylitis and the files for the rest of musculoskeletal disorders, according to: age, gender, Autonomous Community, CIE-9 code, who initiates the file, qualification, resolution, type of professional contingency, contribution regime and CNO-11 classification. To analyze the professional contingency and qualification variables with respect to the rest of variables. To identify sectors susceptible to implementing improvements in preventive activity. Method: This cross-sectional descriptive study will be carried out by collecting the data through the Alfa database (Automation of the Benefit Management Procedure) of the National Social Security Institute. The statistical program R Core Team 2021, version 4.0.5. will be used for the descriptive analysis of the data. (AU)
Subject(s)
Humans , Male , Female , Adult , Middle Aged , Professional Impairment , Musculoskeletal Diseases , Elbow Tendinopathy/epidemiology , Food Industry , Cross-Sectional Studies , Epidemiology, DescriptiveABSTRACT
Congenital leukemia is a rare disease with particular biological and clinical characteristics which differs from those of older children and adults. Here, we describe two cases of congenital acute lymphoblastic leukemia in two newborns with different clinical presentations (leukemia cutis vs. splenomegaly and respiratory distress) and fatal outcome. Both cases shared the expression of myeloid antigens (CD65) and cytogenetic disorders involving the MLL gene (location 11q23) which are associated to extremely poor prognosis.
Subject(s)
Precursor Cell Lymphoblastic Leukemia-Lymphoma/congenital , Precursor Cell Lymphoblastic Leukemia-Lymphoma/diagnosis , Fatal Outcome , Female , Humans , Infant, Newborn , Male , Precursor Cell Lymphoblastic Leukemia-Lymphoma/therapyABSTRACT
Renin-angiotensin system (RAS) in the bone marrow is related to proliferation and cellular differentiation. We investigated the effect of ACE inhibitors (ACEI) captopril (>1mM) and trandolapril (>0.05 mM) and losartan (0.2 mM) on K562 cell line and K562 transfected with c-myc, bcl-x and bcl-2 (KmycB, Kbclx and Kbcl2 respectively). RAS components, proliferation, apoptosis and c-myc expression were analyzed. ACEI and losartan inhibited cell growth, decreased c-myc expression and increased apoptosis. These effects seem to be associated to angiotensin II-induced Smad activation. This work offers a new possible line of treatment for some acute myeloid leukemias and a new area of clinical research.
