ABSTRACT
PURPOSE: To evaluate the efficacy of two products used for at-home bleaching with different application times. METHODS: 80 participants were enrolled and divided into four groups, (1) 10% carbamide peroxide 1 hour a day; (2) 10% carbamide peroxide overnight; (3) 7.5% hydrogen peroxide 1 hour a day; and (4) 7.5% hydrogen peroxide overnight. The duration of treatment was 14 days. Color measurement was performed using a dental spectrophotometer on the right maxillary central incisor and the canine, at baseline and 2 weeks after. Participants recorded daily tooth sensitivity. To evaluate the influence of concentration and time on bleaching results (ΔE) the one-way ANOVA with Bonferroni post-hoc test and the Student's t-test were used. RESULTS: Group 2 showed the highest value of ΔE (ΔE = 10.59 ± 2.68), followed by Group 4 (ΔE = 8.95 ± 2.32), Group 1 (ΔE = 8.05 ± 3.86), and Group 3 (ΔE = 7.08 ± 1.99). There were differences between Groups 2 and 3 (P= 0.001) and between Groups 2 and 1 (P= 0.032). The same product applied overnight was more effective than applied 1 hour a day (P< 0.05). Different concentrations during the same application time achieved similar results. The reported tooth sensitivity was mild. CLINICAL SIGNIFICANCE: At-home bleaching is time but not concentration dependent and its secondary effects depend on the active agent concentration; therefore, there is no need to use high concentration products. The most effective protocol is low concentrations (10% carbamide peroxide) with overnight use.
