[Drug surveillance in hospitalized patients in miscellany ward at children's hospital]. / Farmacovigilancia en pacientes hospitalizados en la sala de miscelánea de un hospital infantil.

BACKGROUND: surveillance of the use of drugs after their commercialization is indispensable for detecting infrequent, but important, adverse effects. The objective was to evaluate adverse reactions and drug interactions detected during the treatment of the patients hospitalized in a pediatric hospital. METHODS: a prospective study in the North Child Hospital "Juan de la Cruz Martínez Maceira," Santiago de Cuba, was carried out, applying the method of intensive surveillance of the hospitalized patients, adapted to our conditions, which were previous informed consent in a sample of 28 patients with different pathologies and pharmacological treatments. The data out was evaluated by Naranjo's algorithm, applying descriptive statistics. RESULTS: ten adverse reactions and three drug interactions were detected after relating clinical and biosocial aspects with pharmacological analysis. CONCLUSIONS: the method of intensive surveillance applied allowed us to identify the adverse reactions and the patients' drug interactions. The pharmacological measures proposals facilitated identifying the number of drug interactions which produce adverse reactions.

Farmacovigilancia en la sala de miscelánea de un hospital infantil

Introducción; después de comercialización de los medicamentos es indispensable la vigilancia de su uso para detectar efectos adversos pocos frecuentes, pero importantes. Por ello el objetivo de este trabajo es evaluar las reacciones adversas y las interacciones medicamentosas detectadas en el tratamiento de los pacientes de un hospital pediátrico.Métodos; estudio prospectivo en el Hospital Infantil Norte Juan de la Cruz Martínez Maceíra de Santiago de Cuba, aplicando el método de vigilancia intensiva del paciente hospitalizado, adaptados a nuestras condiciones, previo consentimiento informado en una muestra de 28 pacientes con diferentes patologías y tratamientos farmacológicos. Los datos obtenidos se evaluaron con el algoritmo de Naranjo, aplicando la estadística descriptiva. Resultados; se detectaron 10 reacciones adversas y tres interacciones medicamentosas, eventos que luego de relacionarlos con aspectos clínicos y biosociales se analizaron farmacológicamente. Conclusiones; el método de vigilancia intensiva aplicado permitió identificar las reacciones adversas e interacciones medicamentosas de los pacientes. Las medidas farmacológicas propuestas posibilitaron disminuir el número de interacciones medicamentosas que produjeron reacciones adversas y así elevar el nivel de vida de los pacientes que reciben estos tratamientos(AU)

Background; the surveillance on the use of drugs after its commercialization is indispensable to detect frequent, but important few adverse effects. The objective was to evaluate adverse reactions and drug interactions detected during the treatment of the patients hospitalized in a Room of Miscellany. Methods; a prospective study in the North Child Hospital Juan de la Cruz Martinez Maceira, Santiago de Cuba, was carried out, applying the method of the hospitalized patient's intensive surveillance, adapted to our conditions previous informed consent in a sample of 28 patients with different pathologies and pharmacological treatments. The data out was evaluated by the Naranjo's algorithm, applying descriptive statistic. Results: ten adverse reactions and three drug interactions were detected. Events that after relating them with clinical and biosocíaí aspects, were analyzed pharmacologically. Conclusions; the method of intensive surveillance applied allowed to identify the adverse reactions and the patients' drug interactions. The pharmacological measures proposals facilitated identified the number of drug interactions wich produce adverse reactions (AU)