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1.
Sci Adv ; 7(7)2021 Feb.
Article in English | MEDLINE | ID: mdl-33568473

ABSTRACT

Isotopic ratios and, in particular, the water D/H ratio are powerful tracers of the evolution and transport of water on Mars. From measurements performed with ExoMars/NOMAD, we observe marked and rapid variability of the D/H along altitude on Mars and across the whole planet. The observations (from April 2018 to April 2019) sample a broad range of events on Mars, including a global dust storm, the evolution of water released from the southern polar cap during southern summer, the equinox phases, and a short but intense regional dust storm. In three instances, we observe water at very high altitudes (>80 km), the prime region where water is photodissociated and starts its escape to space. Rayleigh distillation appears the be the driving force affecting the D/H in many cases, yet in some instances, the exchange of water reservoirs with distinctive D/H could be responsible.

2.
Nature ; 568(7753): 521-525, 2019 04.
Article in English | MEDLINE | ID: mdl-30971830

ABSTRACT

Global dust storms on Mars are rare1,2 but can affect the Martian atmosphere for several months. They can cause changes in atmospheric dynamics and inflation of the atmosphere3, primarily owing to solar heating of the dust3. In turn, changes in atmospheric dynamics can affect the distribution of atmospheric water vapour, with potential implications for the atmospheric photochemistry and climate on Mars4. Recent observations of the water vapour abundance in the Martian atmosphere during dust storm conditions revealed a high-altitude increase in atmospheric water vapour that was more pronounced at high northern latitudes5,6, as well as a decrease in the water column at low latitudes7,8. Here we present concurrent, high-resolution measurements of dust, water and semiheavy water (HDO) at the onset of a global dust storm, obtained by the NOMAD and ACS instruments onboard the ExoMars Trace Gas Orbiter. We report the vertical distribution of the HDO/H2O ratio (D/H) from the planetary boundary layer up to an altitude of 80 kilometres. Our findings suggest that before the onset of the dust storm, HDO abundances were reduced to levels below detectability at altitudes above 40 kilometres. This decrease in HDO coincided with the presence of water-ice clouds. During the storm, an increase in the abundance of H2O and HDO was observed at altitudes between 40 and 80 kilometres. We propose that these increased abundances may be the result of warmer temperatures during the dust storm causing stronger atmospheric circulation and preventing ice cloud formation, which may confine water vapour to lower altitudes through gravitational fall and subsequent sublimation of ice crystals3. The observed changes in H2O and HDO abundance occurred within a few days during the development of the dust storm, suggesting a fast impact of dust storms on the Martian atmosphere.

4.
Medisur ; 12(2): 426-430, abr. 2014.
Article in Spanish | LILACS | ID: lil-760262

ABSTRACT

La piometra es una acumulación de pus en la cavidad endometrial. Aparece cuando existe una estenosis del orificio cervical debida a procesos malignos de cuerpo uterino o de cérvix, tras tratamientos con cirugía o radioterapia y por atrofia senil. Se presenta el caso de una paciente de 84 años remitida al Servicio de Urgencias Hospitalarias del Hospital Universitario Basurto, en Bilbao, España por el médico de la residencia donde se encuentra institucionalizada debido a que presentaba fiebre mantenida desde hacía dos semanas, sin focalidad aparente, diagnosticada como infección urinaria y tratada con amoxicilina-clavulánico. Por los exámenes imagenológicos se diagnosticó piometra en útero bicorne. Fue sometida al drenaje del piometra por vía vaginal, bajo anestesia general, tras dilatación mecánica del canal cervical. Se puso tratamiento con ertapenen. La evolución fue satisfactoria. Por lo poco común del caso se decidió su presentación.


Pyometra is an accumulation of pus in the endometrial cavity. It occurs when there is a stenosed cervical os as a result of malignant growths in the uterus or cervix, surgery or radiation therapy and senile atrophy. We present the case of an 84-year-old female patient referred to the Emergency Service of the Basurto University Hospital in Bilbao, Spain by the doctor of the nursing home where she is institutionalized because of a two-week history of continued fever without apparent cause. She was diagnosed with urinary tract infection and treated with amoxicillin/clavulanate. Based on the imaging tests, a pyometra in bicornuate uterus was diagnosed. She underwent drainage of the pyometra via the vaginal route, under general anesthesia, after mechanical dilation of the cervical canal. Treatment with ertapenen was prescribed. Progression was satisfactory. Given the rarity of this case, we decided to present it.

5.
Rev. cuba. cir ; 52(3): 218-222, jul.-sep. 2013.
Article in Spanish | LILACS | ID: lil-696698

ABSTRACT

La gangrena gaseosa de la mama es una enfermedad rara y potencialmente mortal descrita como consecuencia de un traumatismo, por complicaciones infecciosas de la cirugía o por una trombosis venosa. También se ha relacionado ocasionalmente con otras causas tales como la diabetes mellitus, el envenenamiento con monóxido de carbono o la cirugía plástica. Presentamos un caso de gangrena gaseosa de mama en una mujer diabética de 74 años. Esta rara infección representa una emergencia médico-quirúrgica(AU)


Gas gangrene of the breast is a rare and potentially lethal disease following trauma, as a result of infectious complications from surgery or venous thrombosis. Other rare etiologies, such as diabetes mellitus, carbon monoxide poisoning, and plastic surgery, have also been reported as related to this illness. A case of gas gangrene of the breast found in a 74-year-old diabetic woman was presented in this paper. This rare infection is a medical and surgical emergency situation(AU)


Subject(s)
Humans , Female , Aged , Breast Diseases/diagnosis , Gas Gangrene/pathology , Mastectomy/methods
6.
Prog. obstet. ginecol. (Ed. impr.) ; 56(3): 135-139, mar. 2013.
Article in Spanish | IBECS | ID: ibc-110328

ABSTRACT

Objetivo. Presentación de nuestra experiencia desde octubre del 2009 hasta diciembre del 2011 y comparación de los resultados y las complicaciones con el amplio estudio publicado en el American Journal of Obstetrics and Gynecology (AJOG) en 2011. Material y métodos. Estudio prospectivo de nuestros primeros 55 carcinomas de cuerpo uterino: 50 adenocarcinomas endometrioides, 2 adenocarcinomas seroso-papilares de endometrio y 3 tumores müllerianos mixtos (TMM), tratados mediante laparoscopia asistida por robot (da Vinci) en el Hospital Universitario de Basurto desde octubre del 2009 hasta diciembre del 2011. Las variables analizadas han sido: edad, índice de masa corporal (IMC), tipos histológicos, estadios, tipos de tratamientos, medias del tiempo quirúrgico, media del número de ganglios obtenidos y número y porcentaje de ganglios invadidos, sangrado operatorio y conversiones a laparotomía. Así mismo, se han analizado el número y el porcentaje de las complicaciones intraoperatorias, postoperatorias y totales. Resultados. Media de ganglios pélvicos: 14,44 vs. 13,16. Tiempo operatorio: 181,1/286,5 min vs. 196,33 min. Conversión a laparotomía: 5,45% vs. 2,9%. Complicaciones totales: 16,36% vs. 6,4%. Conclusiones. 1) El número de ganglios pélvicos obtenidos y el tiempo operatorio son similares a los publicados en el estudio del AJOG; 2) la conversión a laparotomía y el porcentaje de complicaciones totales son superiores a los referidos en el estudio del AJOG, quizás debido al menor número de casos y a la menor experiencia (curva de aprendizaje); 3) la laparoscopia asistida por robot es una vía adecuada y con gran futuro en el tratamiento y la estadificación de los carcinomas de cuerpo uterino(AU)


Objective. To present our experience from October 2009 though December 2011 and to compare outcomes and complications with a large study published in the American Journal of Obstetrics and Gynecology (AJOG) in 2011. Material and methods. We performed a prospective study of our first 55 corpus uteri carcinomas: 50 endometrioid adenocarcinomas, two papillary serous carcinomas and three Müllerian adenosarcomas, treated with robot-assisted laparoscopy (da Vinci) in the Basurto University Hospital from October 2009 through December 2011. The variables analyzed were age, body mass index, histologic type, stages, treatment, mean operating time, mean of number of lymph nodes retrieved, the mean number and percentage of involved lymph nodes, surgical bleeding and conversion to laparotomy. We also analyzed the number and the percentage of operative, post-operative and total complications. Results. The mean number of pelvic nodes was 14.44 vs. 13.16. Operating time was 181.1/286.5minutes vs 196.33minutes. Conversion to laparotomy was 5.45% vs. 2.9%. The percentage of total complications was 16.36% vs. 6.4%. Conclusions. 1) The number of pelvic nodes retrieved and the operating time were similar to those reported by the AJOG study. 2) Conversion to laparotomy and the percentage of total complications were higher than those reported in the AJOG study, possibly due to the smaller number of cases and the lesser experience (learning curve). 3) Robot-assisted laparoscopy is a viable approach with an excellent future in the treatment and staging of corpus uteri carcinomas(AU)


Subject(s)
Humans , Female , Pregnancy , Adult , Laparoscopy , Robotics/methods , Robotics , Uterine Neoplasms/therapy , Uterine Neoplasms , Endometrial Neoplasms , Carcinoma, Endometrioid/surgery , Carcinoma, Endometrioid , Robotics/organization & administration , Robotics/trends , Body Mass Index , Uterus/pathology , Uterus , Prospective Studies , Postoperative Complications/prevention & control , Postoperative Complications/therapy , Postoperative Complications
7.
Rev. cuba. obstet. ginecol ; 38(4): 0-0, oct.-dic. 2012.
Article in Spanish | LILACS | ID: lil-665701

ABSTRACT

La vasa previa es una afección rara asociada a una elevada mortalidad perinatal. Los vasos sanguíneos fetales cruzan por encima del orificio cervical interno y son el resultado de una inserción velamentosa del cordón umbilical. Se presenta un caso de sufrimiento fetal agudo letal causado por rotura de un vaso previo durante el segundo periodo del parto. Se comenta la etiología y el manejo clínico de esta afección.


Vasa previa is a rare condition associated with high perinatal mortality. Fetal blood vessels cross over the internal os and they are the result of an insertion cord velamentous. We report a case of fatal acute fetal distress caused by rupture of a vessel in the second period before delivery. We discuss the etiology and clinical management of this condition.

8.
Rev. esp. geriatr. gerontol. (Ed. impr.) ; 47(5): 210-213, sept.-oct. 2012. tab
Article in Spanish | IBECS | ID: ibc-105539

ABSTRACT

Objetivo. El número de pacientes ancianas con cáncer de mama está en aumento y, una proporción elevada de estas pacientes mayores no recibe el tratamiento convencional. Analizamos las características clínicas y biológicas de los tumores a esta edad y la supervivencia en función del tratamiento local o sistémico. Material y método. Estudiamos retrospectivamente a 96 pacientes consecutivas de 80 o más años con cáncer primario de mama diagnosticadas en nuestra Unidad entre enero del 2002 y septiembre del 2008. De ellas, 54 se sometieron a cirugía con o sin tratamiento hormonal adyuvante y 42 recibieron hormonoterapia primaria. Resultados. Las pacientes de más de 80 años tuvieron tumores con características biológicas más favorables, incluyendo tumores que expresaban receptores esteroideos y ausencia de expresión de c-erb B2. La supervivencia global fue de 50 meses para el grupo sometido a cirugía y 44 meses para el grupo no sometido a cirugía. La supervivencia libre de recaída local en el grupo operado fue de 44 meses, mientras que la supervivencia libre de progresión local fue de 18 meses en el grupo no operado. Conclusiones. En una cohorte de mujeres octogenarias, la supervivencia fue similar en las que recibieron tratamiento hormonal o quirúrgico, aunque las primeras tuvieron un período de supervivencia libre de progresión o recidiva local menor(AU)


Background. The number of elderly patients with breast cancer is increasing, and a large proportion of these older patients do not receive conventional treatment. Clinical and biological characteristics of tumours at this age and survival according to local or systemic therapy were analysed. Material and method. A total of 96 consecutive early breast cancer patients over 80 years of age diagnosed in our Unit between January 2002 and September 2008 were retrospectively investigated. Of them, 54 underwent surgery with or without adjuvant hormonal treatment, and 42 received primary hormonal therapy. Results. Tumours of patients 80 years old or older had more favourable biological characteristics, including expression of steroid receptors, and absence of c-erb B2 expression. Overall survival was 50 months for the group subjected to surgery, and 44 months for the group who did not undergo surgery. The survival free of local recurrence in the surgery group was 44 months, whereas it was 18 months in the non-surgery group. Conclusion. In a cohort of patients aged 80 years and older, survival was similar in those who received hormonal or surgical therapy, although the former had a shorter period of progression-free survival or local recurrence(AU)


Subject(s)
Humans , Female , Aged , Aged, 80 and over , Breast Neoplasms/diagnosis , Breast Neoplasms/therapy , Hormones/therapeutic use , Radio Waves/therapeutic use , Aromatase Inhibitors/therapeutic use , Retrospective Studies , Comorbidity , Cohort Studies , Quality of Life
9.
Rev Esp Geriatr Gerontol ; 47(5): 210-3, 2012.
Article in Spanish | MEDLINE | ID: mdl-22868226

ABSTRACT

BACKGROUND: The number of elderly patients with breast cancer is increasing, and a large proportion of these older patients do not receive conventional treatment. Clinical and biological characteristics of tumours at this age and survival according to local or systemic therapy were analysed. MATERIAL AND METHOD: A total of 96 consecutive early breast cancer patients over 80 years of age diagnosed in our Unit between January 2002 and September 2008 were retrospectively investigated. Of them, 54 underwent surgery with or without adjuvant hormonal treatment, and 42 received primary hormonal therapy. RESULTS: Tumours of patients 80 years old or older had more favourable biological characteristics, including expression of steroid receptors, and absence of c-erb B2 expression. Overall survival was 50 months for the group subjected to surgery, and 44 months for the group who did not undergo surgery. The survival free of local recurrence in the surgery group was 44 months, whereas it was 18 months in the non-surgery group. CONCLUSION: In a cohort of patients aged 80 years and older, survival was similar in those who received hormonal or surgical therapy, although the former had a shorter period of progression-free survival or local recurrence.


Subject(s)
Breast Neoplasms/therapy , Aged, 80 and over , Breast Neoplasms/mortality , Breast Neoplasms/pathology , Female , Humans , Neoplasm Staging , Retrospective Studies , Survival Rate
10.
Prog. obstet. ginecol. (Ed. impr.) ; 55(4): 193-195, abr. 2012.
Article in Spanish | IBECS | ID: ibc-99713

ABSTRACT

La aparición de úlceras genitales en niñas y mujeres jóvenes, de aparente origen no venéreo, es una entidad infrecuente, descrita ya a principios del siglo pasado, conocida como úlcera vulvar aguda o de Lipschütz. Es una entidad de incidencia baja, por lo que es poco conocida y genera confusión cuando se presenta. La falta de una etiología clara y su presentación en una población a caballo entre la población pediátrica y mujeres jóvenes aumentan esta confusión. Detallamos un caso a continuación (AU)


The development of genital ulcers, of apparently non-venereal origin, in adolescents and young girls is a rare entity known as acute genital ulcer or Lipschütz ulcer. Because of their low incidence, these ulcers are little known and can cause confusion when they occur. This confusion is increased by the lack of a clear cause and the occurrence of these ulcers in an age group that falls between the pediatric and young adult populations. We describe a case of Lipschütz ulcer treated in our hospital (AU)


Subject(s)
Humans , Female , Child , Adolescent , Genital Diseases, Female/complications , Genital Diseases, Female/diagnosis , Genitalia, Female/injuries , Ulcer/complications , Ulcer/diagnosis , Vulva/injuries , Adrenal Cortex Hormones/therapeutic use , Hematologic Tests/methods , Hematologic Tests , Gangrene/complications , Gangrene/therapy
11.
Prog. obstet. ginecol. (Ed. impr.) ; 54(11): 568-574, nov. 2011. tab, ilus
Article in Spanish | IBECS | ID: ibc-91172

ABSTRACT

Objetivos. Valorar la utilidad de la determinación del pH vaginal en el primer control del embarazo para el diagnóstico de vulvovaginitis y su relación con la patología obstétrica. Material y métodos. Hemos realizado el estudio en 200 embarazadas de bajo riesgo. Efectuamos el pH vaginal en el primer control del embarazo a las gestantes. Independientemente de su sintomatología, tomamos cultivo de exudado vaginal (CEV) a 103 pacientes; a las otras 97 pacientes lo realizamos si tenían síntomas y/o un pH > 4,5. Solo pusimos tratamiento si eran sintomáticas. Seguimos la evolución de sus embarazos para valorar su patología obstétrica y sus partos. Resultados. La media de pH en la muestra fue 4,41 (4,04–4,78). Encontramos una asociación estadísticamente muy significativa entre la elevación de pH vaginal superior a 4,5 y el aislamiento mediante cultivo de Gardnerella vaginalis (G. vaginalis) (p<0,000), con un OR de 35,15 (4,67–730,39). La mayoría de los cultivos fueron normales, y los gérmenes aislados por orden de frecuencia fueron: Candida albicans (C. albicans) (17,5%), G. vaginalis (7,8%) y Streptococcus agalactiae (7,8%), siendo más del 85% de las gestantes portadoras asintomáticas. La patología obstétrica registrada en nuestra muestra ha sido: amenazas de parto prematuro (2%), roturas prematuras de membranas (2%), partos pretérmino (4,5%) y abortos espontáneos (6%). Conclusiones. El pH vaginal puede ser una buena prueba de cribado para el diagnóstico de vaginosis bacterianas. El germen más prevalente en nuestra muestra ha sido C. albicans siendo la mayoría de gestantes portadoras asintomáticas. No hemos encontrado relación entre la patología obstétrica registrada y los gérmenes aislados en los cultivos de exudado vaginal (AU)


Objective. To assess the usefulness of vaginal pH determination in the first prenatal visit in the diagnosis of vulvovaginitis and its association with obstetric abnormalities. Material and methods. We determined vaginal pH in the first prenatal visit in 200 low-risk pregnancies. In 103 women, vaginal secretions were cultured, independently of their symptoms. In the remaining 97 women, culture was performed only if symptoms were present and/or pH was >4.5. Treatment was prescribed in symptomatic women only. The pregnancies were followed up to evaluate obstetric abnormalities and data on deliveries. Results. The mean pH in the study sample was 4.41 (4.04–4.78). We found a statistically significant association (P<.000) between an increase in vaginal pH over 4.5 and isolation through culture of Gardnerella vaginalis (G. vaginalis), with an OR of 35.15 (4.67–730.39). Most cultures were normal. In order of frequency, the identified microorganisms were Candida albicans (C. albicans) (17.5%), G. vaginalis (7.8%) and Streptococcus agalactiae (7.8%). More than 85% of the carriers were asymptomatic. Obstetric pathology in our sample consisted of preterm labor (2%), premature rupture of membranes (2%), preterm delivery (4.5%) and miscarriage (6%). Conclusions. Vaginal pH determination might be an effective screening test for the diagnosis of bacterial vaginosis. The most prevalent microorganism in our sample was C. albicans and most carriers were asymptomatic. We found no relationship between obstetric pathology and the microorganisms isolated in cultures of vaginal secretions (AU)


Subject(s)
Female , Pregnancy , Adult , Humans , Vulvovaginitis/diagnosis , Gardnerella vaginalis/isolation & purification , Candida albicans/isolation & purification , Streptococcus agalactiae/isolation & purification , Vulvovaginitis/pathology , Mass Screening/methods
12.
Prog. obstet. ginecol. (Ed. impr.) ; 54(8): 436-440, ago. 2011.
Article in Spanish | IBECS | ID: ibc-89855

ABSTRACT

Las gestaciones múltiples comportan una exacerbación de los signos y síntomas propios del embarazo y suponen una situación de riesgo tanto para la madre como para los fetos. Una de dichas complicaciones es el síndrome de perfusión arterial inversa gemelar (PAIG, también llamado secuencia TRAP). Es un proceso muy raro (1% de los embarazos gemelares) o 0,3/10,000 recién nacidos vivos que consiste en la coexistencia de un feto normal (llamado «bomba») y un feto acardio. El feto anormal, presenta, en la mayoría de los casos, desarrollo incompleto del polo cefálico, del corazón, de los miembros superiores y de numerosas vísceras. Los miembros inferiores están relativamente bien conservados aunque son frecuentes el pie zambo así como las anomalías en los dedos del pie. Es frecuente el edema en la mitad superior del feto acardio que sugiere higroma quístico. Presentamos un caso acorde con lo referido con anterioridad (AU)


Multiple gestations involve an exacerbation of the signs and own symptoms of the pregnancy, and suppose a situation of risk for the mother as for the fetuses. One of these complications is the twin reverse arterial perfusion (TRAP), a very rare process (1% of the multiple gestations) or 0,3/10000 borned alive, that consists of the coexistence of a normal fetus (called “pump”) and an acardiac fetus. The abnormal fetus, displays, in most of the cases, incomplete development of the cephalic pole, heart, superior members and numerous organs. The lower members are relatively well conserved although the foot is usually bad conformed as well as the anomalies in the toes are frequent. Is frequent the edema in superior half of the fetus. We displayed an agreed case about this matter occurred in our hospital (AU)


Subject(s)
Humans , Female , Pregnancy , Adult , Pregnancy, Multiple , Pregnancy, Multiple/genetics , Fetus/abnormalities , Fetus/surgery , Myocardial Perfusion Imaging , Pregnancy, Multiple/radiation effects , Diseases in Twins/genetics
13.
Rev. cuba. cir ; 49(4): 69-73, oct.-dic. 2010.
Article in Spanish | LILACS, CUMED | ID: lil-584333

ABSTRACT

La evisceración intestinal a través de la vagina después de una histerectomía es una complicación rara. Se presenta el caso de mujer posmenopáusica que presentó una evisceración transvaginal del intestino delgado después de que se le realizara una histerectomía abdominal. Se revisa la epidemiología, causas, diagnóstico y tratamiento(AU)


Transvaginal intestinal evisceration after hysterectomy is a uncommon complication. This is the case of a postmenopausal women presenting with transvaginal evisceration of the small intestine after a abdominal hysterectomy. Epidemiology, causes, diagnosis and treatment are analyzed(AU)


Subject(s)
Humans , Female , Aged, 80 and over , Pelvic Exenteration/methods , Postoperative Complications/etiology , Hysterectomy, Vaginal/adverse effects , Laparotomy/methods , Anti-Bacterial Agents/therapeutic use
14.
Prog. obstet. ginecol. (Ed. impr.) ; 53(3): 116-119, mar. 2010. ilus
Article in Spanish | IBECS | ID: ibc-78224

ABSTRACT

La cirugía es el tratamiento más adecuado para el adenocarcinoma (ACA) de endometrio en estadios tempranos, con lesiones confinadas al útero (estadios I/II).Aunque la vía laparotómica se utiliza todavía con gran frecuencia, la laparoscopia está progresando en gran medida para el tratamiento de estos tumores.Los resultados obtenidos en el tratamiento del ACA de endometrio por vía laparoscópica son excelentes, similares a la laparotomía, con costes parecidos y múltiples ventajas. Por todo ello, la laparoscopia está empezando a ser la vía preferida para muchos ginecólogos oncólogos.Presentamos a continuación un caso de ACA de endometrio, pT: Ib/G1, tratado por laparoscopia: histerectomía vaginal asistida por laparoscopia (HVAL)+doble anexectomía (DA)+citología (C)+linfadenectomía pélvica (LP) en el que se presentó una metástasis en introito vaginal a los 7 meses del tratamiento y otra inguinal a los 14 meses (AU)


Surgery is the optimal treatment for early-stage endometrial adenocarcinoma, with lesions confined to the uterus (stages I/II).Although laparotomy is still frequently employed, the use of laparoscopy to treat these tumors is increasing.The results obtained by laparoscopic surgery in the treatment of endometrial adenocarcinoma are excellent, similar to those of laparotomy, with multiple benefits and similar costs. Therefore, laparoscopy is becoming the preferred option for many gynecological oncologists.We report a case of endometrial carcinoma, pT: Ib/G1 treated by laparoscopy consisting of laparoscopic assisted vaginal hysterectomy+double annexectomy+cytology+pelvic lymphadenectomy, which progressed to vaginal introitus metastasis at 7 months of treatment and inguinal metastasis at 14 months (AU)


Subject(s)
Humans , Female , Middle Aged , Adenocarcinoma/diagnosis , Adenocarcinoma/surgery , Laparoscopy/methods , Endometrial Neoplasms/complications , Endometrial Neoplasms/diagnosis , Neoplasm Metastasis/diagnosis , Neoplasm Metastasis/physiopathology , Neoplasm Metastasis/therapy , Hysterectomy/methods , Adenocarcinoma/physiopathology , Adenocarcinoma , Metrorrhagia/complications , Metrorrhagia/etiology
15.
Prog. obstet. ginecol. (Ed. impr.) ; 53(2): 59-61, feb. 2010.
Article in Spanish | IBECS | ID: ibc-76432

ABSTRACT

Entre las complicaciones de la anticoncepción hormonal destacan las cardiovasculares (doble riesgo de accidente cerebrovascular e infarto isquémico, y riesgo cuatro veces mayor de presentar complicaciones tromboembólicas). A pesar de que la aparición de hipertensión arterial (HTA) es poco frecuente, se han descrito casos de HTA acelerada acompañada de daño renal. Este efecto adverso se ha documentado en relación con los anticonceptivos orales y no se han encontrado en la literatura científica referencias al uso de anticonceptivos transdérmicos pese a la diferencia en su farmacodinamia. Presentamos el caso clínico de una paciente de 22 años que desarrolló HTA maligna con fallo renal tras sustituir anticonceptivos orales por vía transdérmica y que cedió al detener el tratamiento. Son necesarios más estudios para aclarar esta posible relación, pero este hecho aislado remarca la importancia de la recomendación sobre la toma de presión arterial como parámetro de control clínico de las usuarias de anticoncepción hormonal (AU)


Cardiovascular complications are one of the risks of hormonal contraception use (a two-fold risk of stroke and ischemic infarct and a four-fold risk of thromboembolic complications). Although the development of hypertension is infrequent, cases of accelerated hypertension accompanied by renal failure have been described. This adverse effect has been reported in relation to oral contraceptives but there are no references in the literature to the use of transdermal contraceptives, despite differences in the pharmacodynamics between the two routes of administration. We report the case of a 22-year-old woman who developed malignant hypertension with renal failure after replacing oral contraceptives for the transdermal patch. The hypertension resolved after discontinuing transdermal contraceptive use. Further studies are required to clarify this possible association but this isolated case highlights the importance of blood pressure measurement in the monitoring of hormonal contraception users (AU)


Subject(s)
Humans , Female , Adult , Hypertension/complications , Hypertension/drug therapy , Contraceptive Agents/pharmacology , Contraceptive Agents/therapeutic use , Contraceptive Devices/adverse effects , Contraceptive Devices , Contraceptive Devices, Female , Amlodipine/therapeutic use , Risk Factors , Fluorescent Antibody Technique, Direct , Losartan/therapeutic use
16.
Prog. obstet. ginecol. (Ed. impr.) ; 50(11): 621-624, nov. 2007. tab
Article in Es | IBECS | ID: ibc-64659

ABSTRACT

Objetivo: Analizar el valor de la resonancia magnética (RM) en el estudio de la invasión cervical del carcinoma de endometrio en nuestro medio. Material y métodos: Estudio retrospectivo realizado sobre las RM pélvicas (dinámico, con contraste intravenoso con gadolinio) realizadas de manera sistemática en el estudio preoperatorio de los carcinomas endometriales en nuestro servicio. Se realizaron 124 RM pélvicas de las pacientes diagnosticadas de carcinoma de endometrio entre los años 2000 y 2004. Después se contrastaron los resultados con el estudio anatomopatológico de la pieza quirúrgica. Resultados: De las 124 neoplasias analizadas, en 14 había invasión cervical en el estudio histológico, 7 de las cuales eran superficiales (invasión glandular) y otras 7 invadían el estroma. La RM presentó concordancia con la histología en 120 casos. La sensibilidad de este método fue del 71,42%, la especificidad del 97,34%, el valor predictivo positivo (VPP) del 76,92%, el valor predictivo negativo (VPN) del 96,49% y el VPN corregido (VPNc) del 99,09%. Conclusiones: La RM pélvica con contraste intravenoso (gadolinio) es una buena técnica para descartar la invasión cervical (VPNc: 99,09%) en el carcinoma de endometrio y también para confirmar la invasión, aunque en menor medida (VPP: 76,92%)


Objective: To assess the value of magnetic resonance (MRI) in the evaluation of cervical invasion in endometrial carcinoma in our service. Material and methods: We performed a retrospective study of pelvic MRI scans (dynamic, intravenous contrast media with gadolinium) systematically performed in the presurgical study of endometrial carcinoma in our service. A total of 124 pelvic MRI scans were performed in women diagnosed with endometrial carcinoma between 2000 and 2004. The results were compared with those of histological analysis of the surgical specimen. Results: Of the 124 neoplasms studied, 14 were found to have cervical invasion on histological analysis, seven were superficial (glandular invasion) and a further seven invaded the stroma. The results of MRI were concordant with those of histology in 120 patients. The sensitivity of MRI was 71.42%, specificity was 97.34%, the positive predictive value (PPV) was 76.92%, the negative predictive value (NPV) was 96.49% and the corrected negative predictive value (cNPV) was 99.09%. Conclusions: Pelvic MRI with endovenous contrast media (gadolinium) is a good technique to rule out cervical invasion (cNPV: 99.09%) in endometrial carcinoma and, to a lesser extent, to confirm invasion (PPV: 76.92%)


Subject(s)
Humans , Female , Adult , Middle Aged , Aged , Magnetic Resonance Spectroscopy/methods , Neoplasm Invasiveness/diagnosis , Endometrial Neoplasms/diagnosis , Uterine Cervical Neoplasms/pathology
17.
Prog. obstet. ginecol. (Ed. impr.) ; 50(2): 103-105, feb. 2007. ilus
Article in Es | IBECS | ID: ibc-051459

ABSTRACT

Presentamos 2 casos de disgerminomas ováricos tratados en nuestro servicio en el último año. Son tumores que afectan a mujeres jóvenes, por lo que debemos realizar un tratamiento conservador que les permita mantener la fertilidad. La cirugía conservadora, asociada si es necesario a quimioterapia, consigue muy buenos resultados. En el primer caso se realizó cirugía conservadora por tratarse de una mujer joven


We present two cases of ovarian dysgerminoma treated in our hospital in the last year. These tumors affect young women and consequently conservative treatment should be provided to preserve fertility. Conservative surgery associated with chemotherapy, if necessary, provides good results. In the first case, conservative surgery was performed because the patient was a young woman


Subject(s)
Female , Adult , Middle Aged , Humans , Dysgerminoma/surgery , Dysgerminoma/diagnosis , Ovarian Neoplasms/surgery , Ovarian Neoplasms/diagnosis , Biomarkers, Tumor/blood , Tomography, X-Ray Computed
18.
Radiología (Madr., Ed. impr.) ; 47(1): 29-31, ene.-feb. 2005. ilus
Article in Es | IBECS | ID: ibc-036908

ABSTRACT

Presentamos tres casos de linfoma primario de mama en mujeres con edades muy diferentes. Esta patología es muy infrecuente, especialmente en su presentación primaria, y los hallazgos mediante las diferentes técnicas radiológicas disponibles (mamografía, ecografía) son muy inespecíficos. No obstante, existen ciertas características que nos pueden orientar hacia el diagnóstico. Por el momento no existe un tratamiento estándar para esta patología, sino que éste ha de adecuarse a las circunstancias de la paciente


Three cases of primary breast lymphoma affecting women of very different ages are described. Breast lymphoma is very rare, especially as a primary lesion, and the mammographic and ultrasound findings are unspecific. However, certain characteristics can orient the diagnosis. No standard treatment is currently available for this disease and treatment must be adapted to the individual patient’s circumstances


Subject(s)
Female , Adult , Aged , Humans , Lymphoma/diagnosis , Breast Neoplasms/diagnosis , Mammography/methods , Ultrasonography, Mammary/methods , Palpation
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