Estrategias para un envejecimiento exitoso / Strategies for successful ageing

En los últimos años ha habido un aumento en el interés por la medicina antienvejecimiento con un crecimiento de la industria de productos que prometen prolongar la vida y restaurar todo padecimiento o «defecto» producido por la edad. El entendimiento del envejecimiento ha evolucionado, dando cabida a la posibilidad de intervenir en diferentes vías metabólicas y celulares y así, retrasar la aparición de las enfermedades crónicas degenerativas que aparecen con la edad y que finalmente son las causantes de la vulnerabilidad que nos lleva a la muerte. Esperamos poder ayudar al clínico a orientar a sus pacientes, quienes ante la información abrumadora que reciben por Internet, acuden al consultorio llenos de preguntas, esperando recibir del médico la respuesta absoluta para aumentar su longevidad y calidad de vida. Este artículo analiza la actividad física, las dietas, los suplementos y fármacos que se están explorando como medidas antienvejecimiento y de los que múltiples estudios clínicos han arrojado resultados alentadores medibles y reproducibles (AU)

There has been an increase in the interest of anti-ageing medicine in the last few years, with a growth in the industry of products that promise to prolong life and restore all the suffering or «defects» produced by age. The understanding of ageing has changed over the years, giving rise to the possibility of intervening in different metabolic and cellular pathways, and thus, delaying the appearance of the degenerative chronic diseases that appear with age, and that are finally the causing factors of the vulnerability that leads to our death. It is hoped that we can help the clinician to orientate their patients, who, due to the overwhelming amount of information they receive by the Internet, arrive at the clinic full of questions, waiting to receive absolute answer from their physician in order to increase their longevity and quality of life. This article presents an analysis of the physical activity, diets, supplements and drugs that are being investigated as anti-ageing measures and of the many clinical studies that have produced encouraging, measurable and reproducible results (AU)

[Strategies for successful ageing]. / Estrategias para un envejecimiento exitoso.

There has been an increase in the interest of anti-ageing medicine in the last few years, with a growth in the industry of products that promise to prolong life and restore all the suffering or "defects" produced by age. The understanding of ageing has changed over the years, giving rise to the possibility of intervening in different metabolic and cellular pathways, and thus, delaying the appearance of the degenerative chronic diseases that appear with age, and that are finally the causing factors of the vulnerability that leads to our death. It is hoped that we can help the clinician to orientate their patients, who, due to the overwhelming amount of information they receive by the Internet, arrive at the clinic full of questions, waiting to receive absolute answer from their physician in order to increase their longevity and quality of life. This article presents an analysis of the physical activity, diets, supplements and drugs that are being investigated as anti-ageing measures and of the many clinical studies that have produced encouraging, measurable and reproducible results.

Spontaneous rupture of an aneurysm of the sinus of Valsalva into the right atrium, associated with an atrial septal aneurysm.

Aneurysms of the sinus of Valsalva (SV) and the atrial septum are a rare association. We report the case of a 28-year-old woman, who was admitted to our department complaining of progressive dyspnea of 10 days of evolution, five hours previous to her admission to the hospital; she presented sudden oppressive anterior chest pain, accompanied by palpitations. The presence of rupture of the right SV to the right atrium was clinically confirmed, by echocardiography and hemodynamic studies. In addition, an associated atrial septal aneurysm was found. She underwent surgical correction through sinusplasty without requiring aortic valve replacement. The patient presented persistent postoperative atrioventricular block, which required a permanent pacemaker. Clinical evolution was satisfactory. To our knowledge, this case is a rare combination of two isolated malformations, without previous events that could explain the rupture of the right SV.

Spontaneous rupture of an aneurysm of the sinus of Valsalva into the right atrium, associated with an atrial septal aneurysm / Ruptura espontánea de un aneurisma del seno de Valsalva a la aurícula derecha en una paciente con aneurisma del septum interatrial

Aneurysms of the sinus of Valsalva (SV) and the atrial septum are a rare association. We report the case of a 28-year-old woman, who was admitted to our department complaining of progressive dyspnea of 10 days of evolution, five hours previous to her admission to the hospital; she presented sudden oppressive anterior chest pain, accompanied by palpitations. The presence of rupture of the right SV to the right atrium was clinically confirmed, by echocardiography and hemodynamic studies. In addition, an associated atrial septal aneurysm was found. She underwent surgical correction through sinusplasty without requiring aortic valve replacement. The patient presented persistent postoperative atrioventricular block, which required a permanent pacemaker. Clinical evolution was satisfactory. To our knowledge, this case is a rare combination of two isolated malformations, without previous events that could explain the rupture of the right SV.

Los aneurismas del seno de Valsalva y del septum interauricular son una asociación rara. Informamos el caso de una mujer de 28 años de edad con un cuadro de disnea progresiva en los últimos 10 días, al cual se agregó dolor precordial opresivo, cinco horas previas a su ingreso. Se comprobó clínicamente, por ecocardiografía y hemodinamia la presencia de ruptura del seno de Valsalva derecho hacia el atrio derecho. Un hallazgo interesante fue la presencia de un aneurisma del septum interauricular asociado. La paciente fue sometida a corrección quirúrgica con plastía del seno de Valsalva, sin requerir reemplazo valvular aórtico. En el postoperatorio presentó bloqueo aurículo-ventricular persistente, requiriendo implante de marcapaso definitivo. Su evolución fue satisfactoria. Este es un caso de una rara asociación de dos malformaciones aisladas.