Evaluation of the last 2 decades in the characteristics of presentation, management and prognosis of serious spontaneous intracerebral hemorrhage in a third level hospital.

OBJECTIVE: To analyze the change in the characteristics of presentation, evolution and treatment in the ICU, as well as the functional evolution at 12 months of spontaneous intracranial hemorrhages (ICHs) treated in an ICU reference center. PATIENT AND METHODS: Descriptive, retrospective study in a Neurocritical Reference Hospital. All admissions of patients with HICE during three periods are studied: 1999-2001 (I), 2015-2016 (II) and 2020-2021 (III). Evolution in the three periods of demographic variables, baseline characteristics of the patients, clinical variables and characteristics of bleeding, evolutionary data in the ICU are studied. At one year we assessed the GOS scale (Glasgow Outcome Score) according to whether they had a poor (GOS 1-3) or good (GOS 4-5) prognosis. RESULTS: 300 admitted patients, distributed in periods: I: 28.7%, II: 36.3% and III: 35%. 56.7% were males aged 66 (55.5-74) years; ICH score 2 (1-3). The ICU stay was 5 (2-14) days with a mortality of 36.8%. GOS 1-3 a year in 67.3% and GOS 4-5 in 32.7%. Comparing the three periods, we observed a higher prevalence in women, and the presence of cardiovascular factors; no changes in etiology; in relation to the location, it increases cerebellar hemorrhage and in the brainstem. Although the severity was greater, the stay in the ICU, the use of invasive mechanical ventilation and tracheostomy were lower. Open surgery has decreased its use by 50%. Mortality continues to be high, stagnating in the ICU at 35% and entails a high degree of disability one year after assessment. CONCLUSIONS: Severe ICH is a complex pathology that has changed some characteristics in the last two decades, with more severe patients, with more cardiovascular history and a greater predominance of brainstem and cerebellar hemorrhage. Despite the increase in severity, better parameters during the ICU stay, with open surgery used 50% less. Mortality remains stagnant at 35% with high disability per year.

Endocarditis con hemocultivos negativos: infección por Mycoplasma hominis / Culture-negative Endocarditis: mycoplasma hominis Infection

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Influencia de los simbióticos en la disfunción multiorgánica: ensayo aleatorizado / The influence of symbiotics in multi-organ failure: Randomised trial

Fundamento y objetivo: Valorar si la utilización de simbióticos mejora la evolución del síndrome de disfunción multiorgánica (SDMO), la respuesta inflamatoria, el patrón de colonización y las infecciones en la Unidad de Cuidados Intensivos (UCI). Pacientes y método: Ensayo clínico de grupos paralelos con distribución aleatoria sobre administración durante 7 días de Simbiotic Drink® en pacientes con SDMO. Si existía contraindicación para su administración, pancreatitis o neutropenia, los pacientes fueron excluidos. Las variables evaluadas son: evolución delSequential Organ Failure Assessment (SOFA), valores sanguíneos de lactato, fibrinógeno y dímero-D, número de infecciones nosocomiales y patrón de colonización. Resultados: Se incluyeron 89 pacientes, 46 en grupo simbiótico (GS) y 43 en grupo control (GC). La edad mediana fue de 69 años y el 68,5% eran varones. No hubo diferencias en las variables demográficas, puntuaciones de gravedad, variables evolutivas y mortalidad, ni en la evolución del SOFA. El GS presenta menor valor de lactato el segundo día, mayor valor de fibrinógeno los días 5 y 7 y menor valor de los dímeros-D el día 7 de evolución. Se tomaron 895 cultivos para valorar la colonización con 528 gérmenes aislados; no se observaron diferencias en los gérmenes resistentes; en mucosas existió mayor colonización por Candida a partir del tercer día en GC, que desaparece tras el cese de la administración de simbióticos. Veintidós pacientes desarrollaron 33 infecciones en UCI, 14 en el GS (42,4%) y 19 en el GC (57,6%), sin diferencias en los microorganismos, con predominio de candidiasis (4 frente a 0 casos). Conclusiones: La administración de simbióticos presenta una tendencia a mejorar los valores precoces de lactato y los tardíos de fibrinógeno/dímeros-D, y colonización menor por Candida en mucosas. Sin embargo, no tiene influencia en la evolución del SDMO (AU)

Background and objective: To assess whether the administration of symbiotic preparations in patients with multi-organ failure (MOF) diminishes the evolution of the failure, the inflammatory response generated, the colonization pattern and the Intensive Care Unit (ICU) infectious illness. Patients and method: Randomized and controlled trial. All patients with MOF were included. Neutropenia and acute pancreatitis patients were excluded. A symbiotic (Simbiotic Drink1) was administered via enteral feeding during the first 7 days. Variables of interest were: Sequential Organ Failure Assessment (SOFA) score evolution, systemic concentrations of lactate, fibrinogen and D-dimer; skin and mucosa colonization and infectious disease register. Results: Eighty-nine patients were included; 46 in the symbiotic group (SG) and 43 in the control group (CG). There were 68.5% males, with a median age of 69 years. There were no significant differences in the patients’ fundamental characteristics (medical history, age, reason for admission, severity scores), nor in the length of ICU stay or in mortality. Comparing the SG with the CG, there were lower lactate levels on the second day, more fibrinogen levels on the days 5 and 7, and lower D-dimer levels on the day 7. Eight hundred and ninety-five cultures were performed for colonization assessment, with isolation of 528 microorganisms. No differences in microbiological resistance were found; there were more colonization in the SG by Candida in mucous membranes after the third day; this situation resolved after stopping symbiotic administration. Twenty-two patients suffered an infectious disease in ICU, 14 in SG (42.4%) and 19 in CG (57.6%). Although no differences were found in the microbiological pattern, there was a predominance of Candida spp. over other microorganisms (4 vs. 0 cases). Conclusions: The symbiotic preparation Simbiotic Drink1, administered in MOF, results in differences to improve the early lactate levels and late fibrinogen/D-dimer levels as well as mucosa colonization by Candida. There were no differences in the ICU evolution (AU)

[The influence of symbiotics in multi-organ failure: randomised trial]. / Influencia de los simbióticos en la disfunción multiorgánica: ensayo aleatorizado.

BACKGROUND AND OBJECTIVE: To assess whether the administration of symbiotic preparations in patients with multi-organ failure (MOF) diminishes the evolution of the failure, the inflammatory response generated, the colonization pattern and the Intensive Care Unit (ICU) infectious illness. PATIENTS AND METHOD: Randomized and controlled trial. All patients with MOF were included. Neutropenia and acute pancreatitis patients were excluded. A symbiotic (Simbiotic Drink) was administered via enteral feeding during the first 7 days. Variables of interest were: Sequential Organ Failure Assessment (SOFA) score evolution, systemic concentrations of lactate, fibrinogen and D-dimer; skin and mucosa colonization and infectious disease register. RESULTS: Eighty-nine patients were included; 46 in the symbiotic group (SG) and 43 in the control group (CG). There were 68.5% males, with a median age of 69 years. There were no significant differences in the patients' fundamental characteristics (medical history, age, reason for admission, severity scores), nor in the length of ICU stay or in mortality. Comparing the SG with the CG, there were lower lactate levels on the second day, more fibrinogen levels on the days 5 and 7, and lower D-dimer levels on the day 7. Eight hundred and ninety-five cultures were performed for colonization assessment, with isolation of 528 microorganisms. No differences in microbiological resistance were found; there were more colonization in the SG by Candida in mucous membranes after the third day; this situation resolved after stopping symbiotic administration. Twenty-two patients suffered an infectious disease in ICU, 14 in SG (42.4%) and 19 in CG (57.6%). Although no differences were found in the microbiological pattern, there was a predominance of Candida spp. over other microorganisms (4 vs. 0 cases). CONCLUSIONS: The symbiotic preparation Simbiotic Drink, administered in MOF, results in differences to improve the early lactate levels and late fibrinogen/D-dimer levels as well as mucosa colonization by Candida. There were no differences in the ICU evolution.