Subject(s)
Common Cold/drug therapy , Ephedrine/therapeutic use , Naproxen/therapeutic use , Adolescent , Child , Child, Preschool , Common Cold/complications , Double-Blind Method , Drug Combinations , Ephedrine/administration & dosage , Female , Fever/drug therapy , Fever/etiology , Headache/drug therapy , Headache/etiology , Humans , Male , Naproxen/administration & dosage , Nasal Obstruction/drug therapy , Nasal Obstruction/etiologySubject(s)
Antifungal Agents/therapeutic use , Candidiasis, Vulvovaginal/drug therapy , Imidazoles/therapeutic use , Adult , Candidiasis, Vulvovaginal/microbiology , Clotrimazole/therapeutic use , Contraception , Female , Humans , Miconazole/analogs & derivatives , Miconazole/therapeutic use , Prospective StudiesSubject(s)
Acetaminophen/therapeutic use , Dipyrone/therapeutic use , Naproxen/therapeutic use , Pain Measurement , Pain/drug therapy , Adult , Autonomic Nervous System/drug effects , Double-Blind Method , Drug Combinations , Electric Stimulation , Electroencephalography/drug effects , Electromyography , Humans , Male , Median Nerve/physiologySubject(s)
Acquired Immunodeficiency Syndrome/complications , Cytomegalovirus Infections/drug therapy , Ganciclovir/therapeutic use , Adult , Cytomegalovirus Infections/complications , Female , Ganciclovir/adverse effects , Gastrointestinal Diseases/drug therapy , Gastrointestinal Diseases/etiology , Gastrointestinal Diseases/pathology , Humans , Male , Neutropenia/chemically induced , Retinitis/etiology , Retinitis/pathology , Thrombocytopenia/chemically inducedABSTRACT
El efecto relajante de las dosis efectivas 50 de androgenos y progestinas sobre las contracciones in vitro del utero de la rata fue prevenido por la administracion previa de Ca2+ o antagonizada por la adicion posterior de este ion. En todos los casos el Ca2+ fue efectivo para antagonizar el efecto inhibitorio de los esteroides. Sin embargo, con la pregnanolona el calcio fue un poco menos potente para revertir la relajacion, a pesar de que la concentracion del esteroide en este caso fue la menor. El analisis matematico usando la ecuacion de Hanes-Woolf para el estudio cinetico de la interacion entre el ion y las hormonas. Los resultados apoyan la idea de que los esteroides podrian ejercer su efecto relajante sobre la contractilidad uterina disminuyendo la permeabilidad de la membrana al ion calcio
Subject(s)
Animals , Rats , Calcium , In Vitro Techniques , Uterine Contraction , Androgens , ProgestinsABSTRACT
The effectiveness of ring A reduced (5 alpha and 5 beta) testosterone (T) derivatives upon the rat uterus spontaneous contractility was tested in vitro. Compounds with the 3 alpha-hydroxy-5 alpha reduced configuration, such as androsterone and androstanediol, and one 5 beta reduced (5 beta-dihydrotestosterone) elicited a remarkable inhibitory effect upon the myometrial activity. Although steroids with 5 beta reduction were less potent than 3 alpha-hydroxy-5 alpha reduced compounds for depressing the myometrial activity, they were somewhat more potent than T, DHEA, androstenedione and the remaining 5 alpha reduced compounds tested. Therefore, T could act as a "prehormone", accounting for the maintenance of the physiological myometrial activity through its 5-reduced derivatives.
