ABSTRACT
Pityriasis rubra pilaris (PRP) is a rare papulosquamous disorder of unknown aetiology. There are only three cases reported occurring coincident with internal neoplasia. We report a case of this disorder presenting as the initial manifestation of a previously undiagnosed malignancy with metastases in the liver. The primary tumour was not detected. The patient had a complete remission of his PRP with topical steroids alone, but died of the malignancy.
Subject(s)
Hand Dermatoses/etiology , Liver Neoplasms/secondary , Neoplasms, Unknown Primary/complications , Pityriasis Rubra Pilaris/etiology , Adult , Fatal Outcome , Hand Dermatoses/pathology , Humans , Male , Pityriasis Rubra Pilaris/pathologyABSTRACT
A 43-year-old man with ulcerous granulomatous cheilitis and submaxillary lymph node invasion caused by Scopulariopsis brevicaulis infection is described. Administration of itraconazole produced a dramatic and definitive cure. Reported cases of deep mycosis caused by S. brevicaulis infection are also reviewed.
Subject(s)
Dermatomycoses/microbiology , Facial Dermatoses/microbiology , Lymphatic Diseases/microbiology , Melkersson-Rosenthal Syndrome/microbiology , Mitosporic Fungi/isolation & purification , Skin Ulcer/microbiology , Adult , Chronic Disease , Dermatomycoses/diagnosis , Dermatomycoses/therapy , Facial Dermatoses/diagnosis , Facial Dermatoses/therapy , Humans , Lymphatic Diseases/diagnosis , Lymphatic Diseases/therapy , Male , Maxilla , Melkersson-Rosenthal Syndrome/diagnosis , Melkersson-Rosenthal Syndrome/therapy , Skin Ulcer/diagnosis , Skin Ulcer/therapyABSTRACT
A case of an inguinal pulsatile hematoma, secondary to a malignant melanoma, is reported. Considerations about such type of diseases are made. Importance of anatomical Pathology is also noted.
Subject(s)
Hematoma/etiology , Inguinal Canal , Melanoma/complications , Skin Neoplasms/complications , Aged , Female , Hallux , HumansABSTRACT
We report a 63-year-old man with violaceous nummular patches on the trunk. Histopathologic studies were consistent with a diagnosis of malignant angioendotheliomatosis or angiotropic lymphoma. Immunohistochemical study of skin was positive for UCHL-1 antigen and leukocyte common antigen and negative for L-26, Ulex europaeus lectin I, vimentin, cytokeratin, and epithelial membrane antigen. Ultrastructural study ruled out an endothelial origin of the neoplastic cells. These data confirmed the diagnosis of malignant proliferative angioendotheliomatosis. Five years before, a soft tissue lymphoma had been excised. This is an unusual case of malignant angioendotheliomatosis for the following two reasons: (1) a previous association with a soft tissue lymphoma and (2) the rarely described T immunophenotype of neoplastic lymphoid cells.
Subject(s)
Hemangioendothelioma/pathology , Lymphoma, T-Cell, Cutaneous/pathology , Lymphoma , Neoplasms, Multiple Primary , Skin Neoplasms/pathology , Soft Tissue Neoplasms , Hemangioendothelioma/immunology , Humans , Lymphoma/pathology , Male , Middle Aged , Skin Neoplasms/immunology , Soft Tissue Neoplasms/pathologyABSTRACT
A patient with Sjögren's syndrome and seronegative polyarthritis is reported. After piroxicam intake and sun exposure she developed subacute cutaneous lupus erythematosus lesions with Ro antibodies. Despite drug withdrawal, typical cutaneous lesions and serological markers of systemic lupus erythematosus (SLE) progressively appeared. The use of piroxicam and other nonsteroidal anti-inflammatory drugs with photosensitizing potential in patients with Sjögren's syndrome, sicca syndrome or a high suspicion of a collagen disorder should be avoided because these drugs may trigger a latent SLE.
Subject(s)
Lupus Erythematosus, Systemic/physiopathology , Piroxicam/adverse effects , Adult , Antibodies, Antinuclear/analysis , Arthritis/drug therapy , Female , Humans , Lupus Erythematosus, Systemic/immunology , Photosensitivity Disorders/chemically induced , Piroxicam/administration & dosage , Piroxicam/therapeutic use , Sjogren's Syndrome/drug therapyABSTRACT
A 46-years-old man with non familial acrokeratosis verruciformis of Hopf is described. We comment on the clinical and histopathological features of this rare dermatosis and the unsuccessful therapy with etretinate.
