ABSTRACT
Propósito de la revisión: revisar la literatura actual sobre el síndrome hipereosinofílico y establecercuáles son las diferencias y semejanzas con el síndrome de Churg-Strauss. Fuente de datos: revisión estructurada de la literatura médica, en las bases de datos Pubmed, Medline y Cochrane. Selección de estudios: se limitó la búsqueda a los artículos de revisión, guías de manejo y meta-análisis, sin límites en idioma ni fecha de publicación, utilizando los términos MESH: hypereosinophilic síndrome, eosinophilic, Churg-Strauss sindrome. Se acoplaron a términos como: update, review, associations. Extracción de datos: se hizo la lectura del resumen de 232 trabajos de los cuales se seleccionaron 111 que eran representativos para el tema de esta revisión, después de una clasificación y ordenamiento, se procedió a la redacción del texto. Conclusiones: el síndrome hipereosinofílico comprende un grupo heterogéneo de enfermedades con presentaciones clínicas muy variadas, para algunos autores el síndrome de Churg-Strauss o más recientemente conocido como granulomatosis eosinofílica con poliangiítis hace parte de este gran síndrome pero para otros, deben considerarse como entidades aparte. (Acta Med Colomb 2014; 39: 174-184).
Purpose of review: to review the current literature on the hypereosinophilic syndrome and establish which are the differences and similarities with Churg-Strauss syndrome. Source of data: structured review of the medical literature in databases Pubmed, Medline and Cochrane. Study selection: the search was limited to review articles, management guidelines and meta-analysis with no limits on language or publication date, using the MESH terms: hypereosinophilic syndrome, eosinophilic, Churg-Strauss syndrome. These were coupled to terms like:update, review, association. Data extraction: reading of the summary of 232 studies was made. Of these, 111 that were representative for the subject of this review, were selected, and after an ordered classification system, the wording was performed. Conclusions: The hypereosinophilic syndrome comprises a heterogeneous group of diseases with varied clinical presentations; for some authors, Churg-Strauss, more recently known as eosinophilic granulomatosis with polyangiitis, is part of this great syndrome, but for others these should be considered as separate entities. (Acta Med Colomb 2014; 39: 174-184).
Subject(s)
Humans , Male , Female , Adult , Granulomatosis with Polyangiitis , Hypereosinophilic Syndrome , Churg-Strauss Syndrome , Disease , EosinophiliaABSTRACT
BACKGROUND: Allergen immunotherapy has demonstrated usefulness in the management of allergic diseases such as asthma, allergic rhinitis and conjunctivitis. However, little is known about its effectiveness in vernal keratoconjunctivitis (VKC), a disease mediated by IgE and lymphocytes, that can cause loss of visual acuity in a permanent way. OBJECTIVE: To describe safety and effectiveness of allergen immunotherapy in a group of patients with VKC. METHODS: From a sample of 575 patients sensitized to house dust mites, who received ultra-rush immunotherapy for asthma, allergic rhinoconjuctivitis or atopic dermatitis, 28 patients with VKC were selected and a retrospective analysis was performed with the evaluation of factors related to safety, pharmacological treatment and clinical response to immunotherapy.. RESULTS: Twenty eight patients with VKC who received allergen immunotherapy were studied. There were 21 men and 7 women, with an average age of 11 years. A total of 490 doses were administered (35 for build-up and 455 for maintenance) for different periods. The average number of doses per patient was 17. There were no local or systemic reactions. Seventy one percent of the patients presented a clear reduction in the use of medications, with an improvement in symptoms 89% and physical findings 68%. CONCLUSIONS: Allergen immunotherapy seems to be a safe and efficient treatment for patients with VKC, and can contribute along with pharmacological management to the improvement of symptoms and reduction in the use of medications.
