ABSTRACT
Introducción: La incidencia anual de tuberculosis (TB) humana por Mycobacterium bovis ha disminuido considerablemente en los países industrializados desde inicios del sigloXX. El objetivo de este estudio fue conocer las características epidemiológicas, clínicas y microbiológicas de esta enfermedad en Castilla y León (CyL). Métodos: Estudio retrospectivo de los casos de TB por M. bovis de CyL en un periodo de 10 años, comparando la epidemiología, los factores de riesgo y la evolución entre las formas pulmonares (TBP) y extrapulmonares (TBEP). Resultados: Se recopilaron 75 casos de TB por M. bovis: 45 TBP y 31 TBEP. La incidencia acumulada de TB por M. bovis fue de 0,3 casos por 100.000 habitantes. Se mantuvo estable entre el primer y el segundo quinquenio (0,27 vs. 0,33, p = 0,656), a pesar del descenso de la incidencia global de la TB (13,58 vs. 10,71, p < 0,0001). La edad media fue de 66,2 + 21,3 años, principalmente varones (63%) y nacidos en España (92%). TBP fue significativamente más frecuente en varones, mayores de 66 años, con inmunosupresión o fumadores. La mortalidad fue del 9%, asociada a la edad, a la inmunosupresión o a un tratamiento diferente al recomendado por la OMS. Conclusiones: La incidencia de TB por M. bovis en CyL es superior a la de España y otros países europeos, y se mantuvo estable a pesar del descenso de la TB por MTC. Afectó mayoritariamente a población nacida en España que vivía en zonas rurales y con elevada media de edad
Introduction: The annual incidence of tuberculosis (TB) from Mycobacterium bovis in humans has considerably declined in industrialised countries since the early twentieth century. The objective of this study was to determine the epidemiological, clinical and microbiological characteristics of patients with this illness in Castile and León (CyL). Methods: Retrospective study of all M. bovis TB cases in CyL over a 10-year period, comparing the risk factors, the epidemiology and the clinical course between pulmonary (PTB) and extrapulmonary TB (EPTB). Results: 75 cases of TB were due to M. bovis: 45 PTB and 31 EPTB. The annual incidence of TB due to M. bovis was 0.3 cases per 100,000. It remained stable between the first and second five-year period (0.27 vs. 0.33, p = 0.656). However, the overall incidence of TB fell in both five-year periods (13.58 vs. 10.71, p < 0.0001). The mean age was 66.2 + 21.3 years, mainly men (63%) and Spanish patients (92%). PTB was significantly more frequent in men, aged over 66 years, with immunosuppressive conditions or who were smokers. Mortality was 9%, associated with higher age, immunosuppression or treatment different from that recommended by the WHO. Conclusions: The incidence of M. bovis TB in CyL was higher than that for Spain and for other European countries, and remained stable despite the decreased the TB due to MTC. It affected mostly Spanish-born patients who lived in rural areas and with a high mean age
Subject(s)
Humans , Male , Female , Infant, Newborn , Infant , Child, Preschool , Child , Adolescent , Young Adult , Adult , Middle Aged , Aged , Tuberculosis/epidemiology , Tuberculosis/microbiology , Mycobacterium bovis , Retrospective Studies , Spain/epidemiology , Risk Factors , IncidenceABSTRACT
INTRODUCTION: The annual incidence of tuberculosis (TB) from Mycobacterium bovis in humans has considerably declined in industrialised countries since the early twentieth century. The objective of this study was to determine the epidemiological, clinical and microbiological characteristics of patients with this illness in Castile and León (CyL). METHODS: Retrospective study of all M. bovis TB cases in CyL over a 10-year period, comparing the risk factors, the epidemiology and the clinical course between pulmonary (PTB) and extrapulmonary TB (EPTB). RESULTS: 75 cases of TB were due to M. bovis: 45 PTB and 31 EPTB. The annual incidence of TB due to M. bovis was 0.3 cases per 100,000. It remained stable between the first and second five-year period (0.27 vs. 0.33, p=0.656). However, the overall incidence of TB fell in both five-year periods (13.58 vs. 10.71, p<0.0001). The mean age was 66.2+21.3 years, mainly men (63%) and Spanish patients (92%). PTB was significantly more frequent in men, aged over 66 years, with immunosuppressive conditions or who were smokers. Mortality was 9%, associated with higher age, immunosuppression or treatment different from that recommended by the WHO. CONCLUSIONS: The incidence of M. bovis TB in CyL was higher than that for Spain and for other European countries, and remained stable despite the decreased the TB due to MTC. It affected mostly Spanish-born patients who lived in rural areas and with a high mean age.
