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1.

[Cell kinetics in experimental rheumatoid lesions and application in antirheumatic drug research (author's transl)]. / Zellkinetische Studien an rheumatoiden Entzündungsmodellen und deren Bedeutung in der Therapieforschung.

Dreher, R; Schlumberger, H D; Löbbecke, E A; Federlin, K.

Immun Infekt ; 7(1): 14-20, 1979 Feb.

Article in German | MEDLINE | ID: mdl-437821

ABSTRACT

The kinetics of chronic inflammatory cellular infiltrates in antiglobulin-induced arthritis, peritonitis and subcutaneous fibrin granuloma were investigated. Only small numbers of the mononuclear cells were labeled after 3H-thymidine impulse labeling, whereas a high labeling index results after 3H-thymidine labeling of the bone marrow. It is concluded that in experimental arthritis the inflammatory so-called cellular hyperplasia consists in bone marrow derived mononuclear cells. In experimental peritonitis glucocorticoid treatment decreases the 3H-thymidine labeling indices. By means of such labeling studies the antiproliferative and antiexsudative properties of steroids were demonstrated quantitatively. Therefore we suggest to make use of experimental cell kinetics for the recognition of anti-rheumatic drugs.

Subject(s)

Anti-Inflammatory Agents/therapeutic use , Arthritis, Experimental/pathology , Arthritis/pathology , Granuloma/pathology , Peritonitis/pathology , Animals , Autoradiography , Cell Division , Cell Movement , Female , Guinea Pigs , Kinetics

2.

Acetylsalicylic acid intolerance.

Schlumberger, H D; Löbbecke, E A; Kallós, P.

Acta Med Scand ; 196(6): 451-8, 1974 Dec.

Article in English | MEDLINE | ID: mdl-4218444

Subject(s)

Antibodies/analysis , Aspirin/adverse effects , Drug Hypersensitivity/immunology , Adult , Aged , Allergens , Animals , Antigens , Aspirin/therapeutic use , Asthma/drug therapy , Asthma/immunology , Chronic Disease , Drug Hypersensitivity/etiology , Female , Humans , Immune Sera , Immunization, Passive , Immunodiffusion , Immunoglobulins/metabolism , Macaca mulatta/immunology , Male , Middle Aged , Radioimmunoassay , Salicylates/adverse effects , Salicylates/therapeutic use , Skin Tests

3.

[Morphological-physiological investigation on the effect of 5-azacytidine in the nucleolus]. / Morphologisch-physiologische Untersuchung am Nukleolus nach Einwirkung von 5-Azacytidin

Voigt, W H; Löbbecke, E A; Grundmann, E.

Acta Histochem ; Suppl 13(0): 165-76, 1973.

Article in German | MEDLINE | ID: mdl-4138746

Subject(s)

Azacitidine/pharmacology , Cell Nucleolus/drug effects , Animals , Autoradiography , Cell Nucleolus/metabolism , Cell Nucleolus/physiology , Cell Nucleolus/ultrastructure , Cytidine/metabolism , HeLa Cells/drug effects , HeLa Cells/ultrastructure , Histocytochemistry , Humans , In Vitro Techniques , Liver/drug effects , Liver/ultrastructure , Mice , Microscopy, Electron , Tritium

4.

[Morphological and physiological effect of 5-azacytidine on nucleoli]. / Morphologisch-physiologische Untersuchung am Nukleolus narch Einwirkung von 5-Azacytidin

Voigt, W H; Löbbecke, E A; Grundmann, E.

Acta Histochem ; SUPPL 13: 165-76, 1973.

Article in German | MEDLINE | ID: mdl-4143083

Subject(s)

Cell Nucleolus/drug effects , HeLa Cells/drug effects , Liver/drug effects , Animals , Autoradiography , Azacitidine/metabolism , Azacitidine/pharmacology , Cell Nucleolus/metabolism , Endoplasmic Reticulum/drug effects , HeLa Cells/metabolism , HeLa Cells/ultrastructure , Histocytochemistry , Liver/metabolism , Liver/ultrastructure , Mice , Mitochondria, Liver/drug effects , Ribosomes/drug effects

5.

[Experimental study on the proliferation activity of the epithelia of skin transplants]. / Versuche zur Ermittlung der Proliferation des Epithels von Hauttransplantaten.

Löbbecke, E A; Grundmann, E.

Virchows Arch B Cell Pathol ; 9(2): 135-44, 1971.

Article in German | MEDLINE | ID: mdl-5001352

Subject(s)

Epithelium/growth & development , Skin Transplantation , Animals , Autoradiography , Cell Count , DNA/biosynthesis , Epithelial Cells , Hair/cytology , Male , Mice , Thymidine , Time Factors , Transplantation, Autologous , Transplantation, Homologous , Tritium

6.

[Variability of generation time in fetal cell types of rats. Autoradiographic studies following prolonged infusion with 3H-thymidine]. / Variabilität der Generationszeit bei fetalen Zellarten der Ratte. Autoradiographische untersuchungen nach Dauerinfusion mit 3H-Thymidin.

Löbbecke, E A; Schultze, B; Maurer, W.

Exp Cell Res ; 55(2): 176-84, 1969 May.

Article in German | MEDLINE | ID: mdl-5772113

Subject(s)

Cell Differentiation , Cell Division , Embryonic and Fetal Development , Thymidine/metabolism , Animals , Autoradiography , Cartilage/cytology , Cell Division/radiation effects , Epithelial Cells , Intestines/cytology , Kinetics , Muscles/cytology , Myocardium/cytology , Thymidine/administration & dosage , Time Factors , Tritium

7.

[Radioautographic study of the course of interphase in cultivated cells]. / Autoradiographische Untersuchung des Interphaseablaufs gezüchteter Zellen.

Löbbecke, E A; Weissenfels, N.

Acta Histochem ; : Suppl 8:171+, 1968.

Article in German | MEDLINE | ID: mdl-4981936

Subject(s)

Culture Techniques , Mitosis , Animals , Autoradiography , Cell Nucleus/metabolism , Chick Embryo , Thymidine/metabolism , Tritium

8.

[Autoradiographic studies on the variability of generation times of fetal cell types of the rat with the help of continuous infusions of 3H thymidine]. / Autoradiographische Untersuchungen zur Variabilität der Generationszeiten von fetalen Zellarten der Ratte mit Hilfe von Dauerinfusionen mit 3H-Thymidin.

Schultze, B; Löbbecke, E A; Maurer, W.

Acta Histochem ; : Suppl 8:351-7, 1968.

Article in German | MEDLINE | ID: mdl-4981951

Subject(s)

Fetus , Mitosis , Thymidine/administration & dosage , Animals , Autoradiography , Epithelium/growth & development , Female , Intestines , Muscle Development , Myocardium , Pregnancy , Rats , Skin , Thymidine/metabolism , Tongue , Tritium

9.

[Advantages of glutaraldehyde fixation in relation to autoradiographic studies on cultured cells]. / Vorzüge der Glutaraldehyd-Fixation bei autoradiographischen Untersuchungen an gezüchteten Zellen.

Weissenfels, N; Löbbecke, E A.

Naturwissenschaften ; 54(7): 168-9, 1967 Apr.

Article in German | MEDLINE | ID: mdl-4869754

Subject(s)

Aldehydes , Autoradiography , Culture Techniques , Histological Techniques , Animals , Chickens , Glutarates , Microscopy, Phase-Contrast , Muscles/embryology , Thymidine/metabolism , Tritium

10.

[A contribution to the clarification of the amitosis problem]. / Ein Beitrag zur Klärung des Amitose-Problems.

Weissenfels, N; Lobbecke, E A.

Naturwissenschaften ; 54(7): 178, 1967 Apr.

Article in German | MEDLINE | ID: mdl-5585858

Subject(s)

Cell Nucleus/metabolism , Culture Techniques , DNA/biosynthesis , Myocardium/cytology , Myocardium/metabolism , Animals , Chick Embryo , Heart/embryology , Thymidine/metabolism , Tritium

11.

[Induction of somatic mutations in Ephestia by injections of mustard gas solutions]. / Die Auslösung von somatischen Mutationen bei Ephestia durch Injektion von Senfgas-Lösungen.

Löbbecke, E A.

Mol Gen Genet ; 99(2): 115-24, 1967.

Article in German | MEDLINE | ID: mdl-5584164

Subject(s)

Mechlorethamine/pharmacology , Mutagens/pharmacology , Mutation , Radiation Genetics , Animals , Insecta , Mutation/radiation effects

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