ABSTRACT
OBJECTIVE: To analyze the impact of parental Metabolic Syndrome (MS) on adolescents, and to explore the familial aggregation of MS with its components. METHODS: Using a 1:3 case-control familial study design to choose 26 MS male patients as proband and 78 healthy men as controls. Data regarding phenotype of their adolescence offspring were collected. Height, weight, waist circumference (WC), blood pressure, body mass index (BMI), waist-to-hip ratio (WHR) and waist-to-height ratio (WHtR) were measured or calculated. FPG, TC, TG, HDL-C and LDL-C were detected by automatic biochemical analyzer and hs-CRP was detected. RESULTS: WC, WHtR, WHR, DBP and hs-CRP of those adolescents with paternal MS were significantly higher than in controls (P < 0.05). Rates of MS, Obesity depend WC, low level of HDL-C of adolescent with paternal MS were significantly higher than in controls (P < 0.05). The rate of number on MS was significantly higher in case group than in control (r = 0.231, P < 0.05). CONCLUSION: The phenotypes of MS were different between adolescents with or without parental MS, indicating that the familial aggregation of MS had been existed in their adolescent offspring, and mainly presented in central obesity, increased blood pressure and inflammation.
