Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 1 de 1
Filter
Add more filters










Database
Language
Publication year range
1.
Int J Infect Dis ; 14(5): e444-7, 2010 May.
Article in English | MEDLINE | ID: mdl-19695918

ABSTRACT

Good's syndrome (GS) is an immunodeficiency characterized by thymoma, hypogammaglobulinemia, and impaired T-cell function. The clinical manifestations of GS include recurrent or chronic infections from common or opportunistic pathogens. Encephalitis is a rare event, with only anecdotal reports of cytomegalovirus infection. Herein we report the case of a 79-year-old woman with GS who developed subacute motor deficits and cognitive changes. Magnetic resonance imaging (MRI) of the brain disclosed white- and gray-matter lesions, mostly in the right frontal and parietal areas. Polyoma virus JC, the agent of progressive multifocal encephalopathy (PML), was identified in cerebrospinal fluid samples and brain biopsy specimens. After diagnosis, the disease had a rapid fatal course. The present case represents the first reported association between GS and PML.


Subject(s)
Immunologic Deficiency Syndromes/complications , JC Virus/isolation & purification , Leukoencephalopathy, Progressive Multifocal/complications , Aged , Brain/pathology , Fatal Outcome , Female , Humans , Immunohistochemistry , Immunologic Deficiency Syndromes/pathology , Leukoencephalopathy, Progressive Multifocal/pathology , Leukoencephalopathy, Progressive Multifocal/virology
SELECTION OF CITATIONS
SEARCH DETAIL
...