Subject(s)
Life Style , Peritoneal Dialysis, Continuous Ambulatory , Peritoneal Dialysis , Self Care , Adult , Dependency, Psychological , Humans , MaleSubject(s)
Graft Survival , Kidney Transplantation , Pregnancy Maintenance , Pregnancy in Adolescence , Adolescent , Female , Humans , Infant, Newborn , Kidney/physiopathology , Kidney Failure, Chronic/physiopathology , Kidney Failure, Chronic/therapy , Pregnancy , Pregnancy Complications/physiopathology , Pregnancy Complications/therapy , Renal DialysisABSTRACT
Plasma choline levels were measured in patients who received a kidney transplant, in donors who underwent nephrectomy and in nonrenal surgical patients. Choline was measured using a choline kinase assay. Choline levels in patients receiving a kidney fell from 29.8 +/- 1.86 microM before transplantation to 15.7 +/- 2.32 1 day later; this normal level was maintained for at least 7 months and in a single case for 2 years. Kidney donors and nonrenal surgery patients showed a significant decrease in plasma choline on the day following surgery but choline levels returned to normal by 3 days after surgery. Thus a transplanted functional kidney reduced the high plasma choline levels, associated with uremia, to normal and maintained these normal levels throughout the period of observation.
