Subject(s)
Myiasis/diagnosis , Travel , Animals , Back , Female , Humans , Italy , Larva , Middle Aged , Myiasis/pathologySubject(s)
Cornea/surgery , Refractive Surgical Procedures , Forecasting , Humans , Ophthalmology/methods , Optometry/methodsABSTRACT
The excimer laser will have a tremendous impact on the future of eye care. This article covers the basic concepts of photorefractive and phototherapeutic keratectomy. Preoperative, operative, and postoperative techniques are reviewed. Common postoperative complications are discussed. This article also reviews clinical data and future trends in excimer technology. A comparison of photorefractive keratectomy with radial keratotomy is also provided.
Subject(s)
Cornea/surgery , Keratotomy, Radial/methods , Photorefractive Keratectomy , Refractive Surgical Procedures , Humans , Keratotomy, Radial/adverse effects , Lasers, Excimer , Photorefractive Keratectomy/adverse effects , Photorefractive Keratectomy/methods , Photorefractive Keratectomy/trends , Postoperative Care , Postoperative ComplicationsSubject(s)
Cornea/surgery , Laser Therapy , Myopia/surgery , Follow-Up Studies , Humans , Postoperative Complications , Treatment Outcome , United StatesABSTRACT
This paper presents the numerous similarities between Norrie's disease and bilateral persistent hyperplastic primary vitreous. A description of each disease is given, as well as a case report which demonstrates the difficulty in distinguishing the two disease processes when there is a negative family history of blindness. A discussion section focuses on the need for a better differential protocol for Norrie's disease, which would aid the clinician when a family history of blindness is absent.
Subject(s)
Deafness/genetics , Intellectual Disability/genetics , Retina/abnormalities , Vitreous Body/pathology , Blindness/congenital , Child , Diagnosis, Differential , Humans , Hyperplasia , MaleSubject(s)
Arthritis/blood , Psoriasis/blood , beta 2-Microglobulin/metabolism , Adult , Female , Humans , Male , Middle AgedABSTRACT
Pre-treatment Serum Beta 2-microglobulin (S B2-m) and OKT4/OKT8 Ratio (T4/T8 R) were studied in 15 patients with Mycosis Fungoides (MF) and in 10 subjects with Chronic Superficial Benign Dermatitis (CSBD) in order to verify whether these parameters may lend support to an earlier differential diagnosis. S B2-m levels and T4/T8 R showed no significant difference in CSBD as compared to normal controls. MF patients displayed elevated S B2-m and T4/T8 R values in comparison to healthy controls and subjects suffering from CSBD (P less than 0.001). After photochemotherapy (PUVA), markedly decreased S B2-m and T4/T8 R values were observed in all patients but two who proved to be unresponsive to PUVA treatment. On the basis of reported data, S B2-m and T4/T8 R can be regarded as an additional tool to discriminate CSBD and MF when clinical and histological features are not significantly diagnostic. Finally, these parameters seem to provide reliable information in monitoring response to treatment.
Subject(s)
Dermatitis/blood , Mycosis Fungoides/blood , beta 2-Microglobulin/metabolism , Adult , Antibodies, Monoclonal , Dermatitis/diagnosis , Diagnosis, Differential , Female , Humans , Leukocyte Count , Male , Middle Aged , Mycosis Fungoides/diagnosis , Mycosis Fungoides/therapy , PUVA Therapy , T-Lymphocytes, Helper-Inducer , T-Lymphocytes, RegulatoryABSTRACT
Peripheral blood mononuclear cells (PBMC), as defined by monoclonal antibodies (OKT3, OKT4, OKT8, OK 1, Leu 7, Leu 11b) were determined in 10 psoriatic patients and in 10 healthy subjects before and after administration of short-term PUVA therapy. A comparison of the mean baseline percentages of the two groups showed a statistically significant increase in Leu 7+ cells (p less than 0.001) as well as a slight increase in OKM1 and OKT8 positive cells in the psoriatic subjects. After 21 exposures, these subsets showed a reduction towards control values, while a significant increase in OKT3 and OKT4 positive cells (p less than 0.01) could be observed only in the control group. These results indicate that short-term PUVA therapy is associated with changes in PBMC subpopulations. This modification, however, does not necessarily imply a disturbance of immune system function, including natural killer activity.
