ABSTRACT
A study was made of a vasodilating effect of nifedipine on the hemodynamics of 30 patients with chronic postinfarction left ventricular aneurysm, with chronic cardiovascular insufficiency of the II-III degree according to NYHA. A mean value of the acontractile segment on ventriculograms was 32.5 +/- 1.7%. The main parameters of systemic hemodynamics were studied by a method of integral body rheography 1 hour before and after sublingual intake of 20 mg of nifedipine (Corinfar, GDR) at rest, after exercise and during rehabilitation. An increase in the stroke and cardiac indices at rest by an average of 16% was revealed including a noticeable nifedipine effect in patients with elevated final diastolic pressure or arterial tension. During physical exercise a tendency toward an increase in the cardiac output was observed, mainly at the expense of a rise of the stroke volume after drug intake.
Subject(s)
Cardiomyopathy, Dilated/drug therapy , Heart Aneurysm/complications , Hemodynamics/drug effects , Myocardial Infarction/complications , Nifedipine/therapeutic use , Adult , Blood Pressure/drug effects , Cardiac Output/drug effects , Cardiomyopathy, Dilated/etiology , Chronic Disease , Humans , Male , Middle AgedABSTRACT
It was discovered that patients suffering from essential hypertension (EH) of the hypokinetic circulatory type (the cardiac index less than 2.7 1/min/m2) manifest an elevated level of energy metabolism which is mediated by the increased arteriovenous difference according to oxygen, accompanied by an increase in oxygen utilization ratio. In patients, the total peripheral resistance was higher as compared to that in normal subjects (P less than 0.01). In patients with EH of the hyperkinetic circulatory type (the cardiac index over 3.4 1/min/m2), there was a considerable increment of the outward work of the heart left ventricle, reduction in the arteriovenous difference according to oxygen, and diminution of the oxygen utilization ratio as compared with normal subjects. At the same time the energy metabolism and total peripheral vascular resistance did not differ from those in the control group (P greater than 0.05).
