Subject(s)
Cytomegalovirus Infections/diagnostic imaging , Endosonography , Gastritis/diagnostic imaging , Linitis Plastica/diagnostic imaging , Stomach Neoplasms/diagnostic imaging , Antibodies, Viral/analysis , Biopsy , Cytomegalovirus/immunology , Cytomegalovirus Infections/pathology , Cytomegalovirus Infections/virology , Diagnosis, Differential , Gastric Mucosa/pathology , Gastric Mucosa/virology , Gastritis/pathology , Gastritis/virology , Gastroscopy , Humans , Linitis Plastica/pathology , Male , Middle Aged , Stomach Neoplasms/pathologyABSTRACT
OBJECTIVES: We report the efficacy of alteplase (a recombinant tissue plasminogen activator) with heparin or heparin alone in the treatment of acute thrombosis of the portal venous system. METHODS: Ten consecutive patients with acute portal venous system thrombosis were studied. Five patients were treated with alteplase and heparin, and the remaining 5 patients, who were asymptomatic or had a contraindication to alteplase, were treated with heparin alone. RESULTS: In 3 of the 5 patients treated with alteplase, ultrasonography showed total resolution of the thrombus; the remaining 2 had partial resolution of the thrombus. In 4 of the 5 patients treated with heparin alone, ultrasonography showed total resolution of the thrombus, and no change in one. No bleeding occurred. CONCLUSION: Treatment with heparin can result in complete recanalisation of acute portal venous system thrombosis. These data suggest that combined therapy with systemic alteplase does not increase the efficacy of heparin.