ABSTRACT
We report a case of 31-year-old woman presented with a chronic pelvic pain and a 3-cm left ovarian cyst on ultrasonography. At the time of laparoscopy, we observed two blue peritoneal lesions at the pelvic insertion of left round ligament. Histopathological examination of a biopsy showed a pigmentation due to a decorative tattoo of the left thigh.
Subject(s)
Pelvic Pain/diagnosis , Tattooing/adverse effects , Adult , Chronic Disease , Female , Humans , Laparoscopy/methods , Ovarian Cysts/diagnostic imaging , Pelvis , Peritoneum , Round Ligament of Uterus , Thigh , UltrasonographyABSTRACT
We report two cases of pneumocystis pneumonia in patients receiving chemotherapy for breast cancer. These case series emphasize the frailty of the patients as the causative role for occurrence of this uncommon complication of chemotherapy in breast cancer. We remind the importance of screening for unusual adverse events in frail patients receiving chemotherapy.
Subject(s)
Antineoplastic Agents/adverse effects , Breast Neoplasms/drug therapy , Pneumonia, Pneumocystis/chemically induced , Taxoids/adverse effects , Aged , Docetaxel , Female , Humans , Middle AgedABSTRACT
We report a case of T1N0 left breast cancer in a 47-year-old woman. Histopathological examination of a non sentinel axillary lymph node showed a pigmentation due to a decorative tattoo of the arm. The authors discuss a new concept: Axillary Reverse Mapping.
Subject(s)
Breast Neoplasms/pathology , Coloring Agents/analysis , Lymph Nodes/pathology , Tattooing/adverse effects , Breast Neoplasms/drug therapy , Breast Neoplasms/radiotherapy , Combined Modality Therapy , Female , Humans , Middle AgedABSTRACT
Cavernous angiomas are vascular malformations mostly located in the central nervous system and characterized by enlarged capillary cavities without intervening brain parenchyma. Clinical symptoms include seizures, haemorrhage and focal neurological deficits. Cavernous angiomas prevalence is close to 0.5% in the general population. They may be inherited as an autosomal dominant condition in as much as 50% of cases. Cerebral cavernous malformations (CCM) loci were previously identified on 7q, 7p and 3q (refs 4,5). A strong founder effect was observed in the Hispano-American population, all families being linked to CCM1 on 7q (refs 4,7). CCM1 locus assignment was refined to a 4-cM interval bracketed by D7S2410 and D7S689 (ref. 8). Here we report a physical and transcriptional map of this interval and that CCM1, a gene whose protein product, KRIT1, interacts with RAP1A (also known as KREV1; ref. 9), a member of the RAS family of GTPases, is mutated in CCM1 families. Our data suggest the involvement of the RAP1A signal transduction pathway in vasculogenesis or angiogenesis.
