A novel test device and quantitative colorimetric method for the detection of human chorionic gonadotropin (hCG) based on Au@Zn-salen MOF for POCT applications.

The human chorionic gonadotropin (hCG) hormone is a biomarker that can predict tumors and early pregnancy; however, it is challenging to develop sensitive qualitative-quantitative procedures that are also effective, inventive, and unique. In this study, we used a novel easy in situ reaction of an organic nano-linker with Zn(NO3)2·6H2O and HAuCl4·3H2O to produce a gold-zinc-salen metal-organic framework composite known as Au-Zn-Sln-MOF. A wide variety of micro-analytical instruments and spectroscopic techniques were used in order to characterize the newly synthesized Au-Zn-Sln-MOF composite. Disclosure is provided for a novel swab test instrument and a straightforward colorimetric approach for detecting hCG hormone based on an Au-Zn-Sln-MOF composite. Both of these methods are easy. In order to validate a natural enzyme-free immunoassay, an Au-Zn-Sln-MOF composite was utilized in the role of an enzyme; a woman can use this gadget to determine whether or not she is pregnant in the early stages of the pregnancy or whether or not her hCG levels are excessively high, which is a symptom that she may have a tumor. This cotton swab test device is compatible with testing of various biological fluids, such as serum, plasma, or urine, and it can be easily transferred to the market to commercialize it as a costless kit, which will be 20-30% cheaper than what is available on the market. Additionally, it can be used easily at home and for near-patient testing (applications of point-of-care testing (POCT)).

Prostate-Specific Antigen Monitoring Using Nano Zinc(II) Metal-Organic Framework-Based Optical Biosensor.

BACKGROUND: The prostate-specific antigen (PSA) is an important cancer biomarker that is commonly utilized in the diagnosis of prostate cancer. The development of a PSA determination technique that is rapid, simple, and inexpensive, in addition to highly accurate, sensitive, and selective, remains a formidable obstacle. METHODS: In this study, we developed a practical biosensor based on Zn(II) metal-organic framework nanoparticles (Zn-MOFs-NPs). Many spectroscopic and microanalytical tools are used to determine the structure, morphology, and physicochemical properties of the prepared MOF. RESULTS: According to the results, Zn-MOFs-NPs are sensitive to PSA, selective to an extremely greater extent, and stable in terms of chemical composition. Furthermore, the Zn-MOFs-NPs did not exhibit any interferences from other common analytes that might cause interference. The detection limit for PSA was calculated and was 0.145 fg/mL throughout a wide linear concentration range (0.1 fg/mL-20 pg/mL). CONCLUSIONS: Zn-MOFs-NPs were successfully used as a growing biosensor for the monitoring and measurement of PSA in biological real samples.

Recycling for solar photocatalytic activity of Dianix blue dye and real industrial wastewater treatment process by zinc oxide quantum dots synthesized by solvothermal method.

Solar photocatalytic activity of zinc oxide quantum dots (ZOQDs) was investigated and two samples of ZOQDs were synthesized by solvothermal method and characterized using different spectroscopic techniques. Crystal and morphological properties were obtained from XRD and HRTEM showed the purity, high crystallinity single phase and the elongated shape of prepared quantum dots. The measured crystallite size of the S1 and S2 samples is 8.4 and 9.6 nm respectively. The results of BET analysis and the optical properties of the samples shown that the first sample have larger values for both the specific surface area and band gap energy. Estimation of the photocatalytic performance indicated that the first sample give the best degradation rate of the synthetic Dianix Blue dye (DB) dye (2.47 × 10-2 s-1). Likewise, in the photo-oxidation of coumarin, the sample with the smallest particle size achieves the highest by 20% fluorescence rate than the largest particle size sample. In addition, the work included a study of the mineralization and recycling efficiency of industrial wastewater as a study case in the presence of different doses of ZOQDs by sun light for a one year and this evaluation done according to Egyptian allowed COD limit according to local environmental ministry law.

Benzimidazole - Schiff bases and their complexes: synthesis, anticancer activity and molecular modeling as Aurora kinase inhibitor.

A new series of Schiff bases containing benzіmidazole moiety 11-17 were synthesized by the reaction of 4-(1H-benzо[d]іmіdazоl-2-yl)anіline (1) with different aromatic aldehydes (4-10) via conventional heating and microwave irradiation methods. The structures of the novel Schiff bases were characterized by using different spectral data. Also, metal complexes 18-21 of compound 13 were synthesized, and their structure was confirmed by spectral measurements (IR, NMR, UV), molar conductivity, magnetic susceptibility and thermo-gravimetric analysis. The novel synthesized ligand 13 and its complexes 18-21 were tested for their in vitro antitumor activities towards breast, liver and lung cancer cell lines. Also, the acute toxicity of the prepared compounds 13 and 18-21 was determined in vivo. The results showed that the newly synthesized compounds 13 and 18-21 exhibited a significant activity against cancer, especially for complex 21, compared to standard drug doxorubicin. The molecular docking of complexes 20 and 21 has been also studied as Aurora kinase inhibitors.