1.
Structural requirements for biological activity among antileukemic glaucarubolone ester quassinoids.
J Med Chem
; 19(9): 1130-3, 1976 Sep.
Article
in English
| MEDLINE
| ID: mdl-978677
ABSTRACT
A C-15 ester substituent is required for significant antileukemic activity among the glaucarubolone ester quassinoids, and variations in the ester group are not accompanied by particularly marked changes in antileukemic activity. Unsaturation at the 3,4 position is advantageous for optimal activity, and hydrogenation of this double bond results in marked diminution in both cytotoxicity toward KB cells in tissue culture and inhibitory activity against the P-388 lymphocytic leukemia in mice.
Subject(s)
Antineoplastic Agents/chemical synthesis , Glaucarubin/chemical synthesis , Pyrans/chemical synthesis , Animals , Antineoplastic Agents/therapeutic use , Cell Line , Glaucarubin/analogs & derivatives , Glaucarubin/pharmacology , Glaucarubin/therapeutic use , Leukemia, Experimental/drug therapy , Mice , Structure-Activity Relationship
2.
J Org Chem
; 40(5): 648-54, 1975 Mar 07.
Article
in English
| MEDLINE
| ID: mdl-1133627
3.
J Org Chem
; 40(5): 654-6, 1975 Mar 07.
Article
in English
| MEDLINE
| ID: mdl-1133628
4.
J Air Pollut Control Assoc
; 22(5): 359-63, 1972 May.
Article
in English
| MEDLINE
| ID: mdl-5041617
