Impact of dual-chamber pacing with closed loop stimulation on quality of life in patients with recurrent reflex vasovagal syncope: results of the SPAIN study.

AIMS: Reflex vasovagal syncope (VVS) is the most common cause of syncope and patients with recurrent episodes may severely impair quality of life (QoL). This pre-specified analysis evaluated whether the clinically significant reduction in syncope burden demonstrated by dual-chamber pacing with closed loop stimulation (DDD-CLS) reported in the SPAIN trial translates into improved QoL. METHODS AND RESULTS: Patients aged ≥40 years with ≥5 VVS episodes and cardioinhibitory response induced by head-up tilt testing were included. Patients were randomized 1:1 to active DDD-CLS pacing algorithm for 12 months followed by sham DDI mode for the remaining 12 months (Group A) or vice versa (Group B). QoL was assessed using the Short Form-36 (SF-36) health survey, Physical Component Score (PCS), and Mental Component Score (MCS) before randomization (baseline) and at 12- and 24-month follow-up. Fifty-four patients were enrolled from 11 participating centres. No significant carryover effect was detected for any variable, and the only period effect was observed in the vitality subdomain (P = 0.033). Mean SF-36 scores were higher in the DDD-CLS group vs. the DDI group for the eight subdomains and significantly different in physical role, bodily pain, and vitality (P < 0.05). The analysis of component summary scores indicated that DDD-CLS benefited both mental and physical components with significant differences in PCS when compared with the DDI group. CONCLUSION: Dual-chamber pacing with closed loop stimulation determined a significant and clinically relevant improvement in QoL across both mental and physical components in patients with recurrent VVS. REGISTRATION: Closed Loop Stimulation for Neuromediated Syncope (SPAIN Study); NCT01621464.

Selección de lo mejor del año 2017 sobre la utilidad de la estimulación cardiaca en el tratamiento del síncope vasovagal / Selection of the best of 2017 on the usefulness of cardiac stimulation in the treatment of vasovagal syncope

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Dual-Chamber Pacing With Closed Loop Stimulation in Recurrent Reflex Vasovagal Syncope: The SPAIN Study.

BACKGROUND: Pacing in vasovagal syncope remains controversial. OBJECTIVES: The authors evaluated dual-chamber pacing with closed loop stimulation (DDD-CLS) in patients with cardioinhibitory vasovagal syncope. METHODS: This randomized, double-blind, controlled study included Canadian and Spanish patients age ≥40 years, with high burden syncope (≥5 episodes, ≥2 episodes in the past year), and a cardioinhibitory head-up tilt test (bradycardia <40 beats/min for 10 s or asystole >3 s). Patients were randomized to either DDD-CLS pacing for 12 months followed by sham DDI mode pacing at 30 pulses/min for 12 months (group A), or sham DDI mode for 12 months followed by DDD-CLS pacing for 12 months (group B). Patients in both arms crossed-over after 12 months of follow-up or when a maximum of 3 syncopal episodes occurred within 1 month. RESULTS: A total of 46 patients completed the protocol; 22 were men (47.8%), and mean age was 56.30 ± 10.63 years. The mean number of previous syncopal episodes was 12 (range 9 to 20). The proportion of patients with ≥50% reduction in the number of syncopal episodes was 72% (95% confidence interval [CI]: 47% to 90%) with DDD-CLS compared with 28% (95% CI: 9.7% to 53.5%) with sham DDI mode (p = 0.017). A total of 4 patients (8.7%) had events during DDD-CLS and 21 (45.7%) during sham DDI (hazard ratio: 6.7; 95% CI: 2.3 to 19.8). Kaplan-Meier curve was significantly different between groups in time to first syncope: 29.2 months (95% CI: 15.3 to 29.2 months) versus 9.3 months (95% CI: 6.21 months, NA; p < 0.016); odds ratio: 0.11 (95% CI: 0.03 to 0.37; p < 0.0001). CONCLUSIONS: DDD-CLS pacing significantly reduced syncope burden and time to first recurrence by 7-fold, prolonging time to first syncope recurrence in patients age ≥40 years with head-up tilt test-induced vasovagal syncope compared with sham pacing. (Closed Loop Stimulation for Neuromediated Syncope [SPAIN Study]; NCT01621464).

Oclusión iatrogénica de arteria circunfleja: imagen intracoronaria / Iatrogenic occlusion of the circumflex artery: Intracoronary image

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Ulceración tardía de la pared vascular tras implante de stent liberador de sirolimus / Peri-stent ulcer like appearance late after sirolimus-eluting stent implantation

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Modelo de intervención coronaria percutánea primaria en la Región de Murcia / The primary percutaneous coronary intervention program in Murcia

Antes de la implantación del programa, la intervención coronaria percutánea primaria era la excepción en el tratamiento del infarto agudo de miocardio, a pesar de que se reperfundía con fibrinolíticos a menos del 40% de los pacientes. Desde 1998 se comenzó a tratar con intervención coronaria percutánea primaria a todos los pacientes que acudían al Hospital Universitario Virgen de la Arrixaca. En el año 2000, se diseñó un programa de tratamiento del infarto agudo de miocardio con intervención coronaria percutánea primaria para toda la Región de Murcia, al que se denominó APRIMUR, estableciendo una primera fase que sólo incluía los tres hospitales de la capital. El programa se hizo extensible al resto de la Región en 2001. Se describe del programa sus primeras fases, el transporte, la metodología de trabajo, los objetivos primarios y secundarios, lo que consideramos puntos clave y su sostenibilidad. Se han realizado más de 3.500 intervenciones coronarias percutáneas primarias, con una media mensual actual de 40-45 casos. La mortalidad ha ido variando desde cifras anuales superiores al 10% a las más actuales del 6% en 2007 y el 6,6% en 2009. Hemos conseguido que, al menos en la mitad de la Región, las cifras de reperfusión superen el 90% y vayan aumentando anualmente en el resto de las comarcas (AU)

Before the primary percutaneous coronary intervention program was implemented, few acute myocardial infarction patients were treated using the technique, even though less than 40% were reperfused using thrombolytic agents. In 1988, we started to use primary percutaneous coronary intervention to treat all patients admitted with acute myocardial infarction to the Virgen de la Arrixaca University Hospital in Murcia, Spain. In 2000, we developed a program, APRIMUR, to treat acute myocardial infarction using primary percutaneous coronary intervention throughout the Murcia region. The first phase involved only three hospitals in the regional capital. The program was then extended to the rest of the region in 2001. This article describes the first phases of the program, including patient transport and work methodology, the primary and secondary aims of the program, what we regard as the program’s key features, and the sustainability of the program. More than 3500 primary percutaneous coronary interventions have now been performed, at a mean rate of 40-45 per month. Annual mortality ranged from more than 10% at the beginning of the program to, more recently, 6.0% in 2007 and 6.6% in 2009. We have achieved a reperfusion rate greater than 90% in at least half the region and the rate is increasing each year in the remaining districts (AU)

Emergency percutaneous coronary intervention in unprotected left main coronary arteries. Predictors of mortality and impact of cardiogenic shock.

INTRODUCTION AND OBJECTIVES: Percutaneous coronary intervention (PCI) for unprotected left main coronary artery (LMCA) disease may be essential following acute myocardial infarction (AMI). However, few data are available on the use of emergency PCI in unprotected LMCAs outside of clinical trials. The objective of this study was to determine the frequency of in-hospital mortality, its predictors and its association with cardiogenic shock, and long-term outcomes in patients with unprotected LMCA disease who undergo emergency PCI because of AMI. METHODS: The study included 71 consecutive patients who underwent emergency angioplasty of the LMCA and who were followed up clinically. RESULTS: Overall, 42 patients (59%) had ST-elevation AMI and 47 (66%) had cardiogenic shock or developed it during PCI. Eleven patients (16%) died in the catheterization laboratory and 33 (47%) died during hospitalization. Inhospital mortality was similar in those with and without evidence of ST-segment elevation on ECG (48% vs. 45%; P=1). Multivariate analysis showed that the predictors of in-hospital mortality were cardiogenic shock (odds ratio [OR]=4.5; 95% confidence interval [CI], 1.1-18) and incomplete revascularization (OR=5.1; 95% CI, 1.0-26). After discharge, 39 patients were followed up for a median of 32 months. Mortality in the first year was 10%. CONCLUSIONS: Emergency PCI is a viable therapeutic option for AMI due to unprotected LMCA disease. However, in-hospital mortality is high, regardless of ST-segment elevation, particularly if there is cardiogenic shock or complete revascularization has not been achieved.

Intervencionismo percutáneo urgente sobre el tronco coronario izquierdo no protegido. Factores predictores de mortalidad y análisis del shock cardiogénico / Emergency percutaneous coronary intervention in unprotected left main coronary arteries. Predictors of mortality and impact of cardiogenic shock

Introducción y objetivos. El intervencionismo coronario percutáneo (ICP) de la enfermedad de tronco coronario izquierdo (TCI) no protegido puede ser necesaria en el infarto agudo de miocardio (IAM). Sin embargo, la evidencia del ICP urgente en el TCI fuera de ensayos clínicos no es muy amplia. El objetivo del estudio es evaluar la mortalidad intrahospitalaria, sus predictores y su asociación con shock, así como eventos a largo plazo en pacientes con enfermedad de TCI tratado con ICP urgente debido a un IAM. Métodos. Se incluyó a 71 pacientes consecutivos en los que se realizó una angioplastia urgente sobre el TCI y seguimiento clínico posterior. Resultados. Presentaron IAM con elevación del ST 42 (59%) y presentaban shock cardiogénico o lo desarrollaron durante el procedimiento 47 (66%). Murieron en la sala de hemodinámica 11 (16%) y 33 (47%) durante la hospitalización. La mortalidad intrahospitalaria fue independiente de la elevación del ST en el ECG (el 45 frente al 48%; p = 1). Los predictores multivariables de mortalidad intrahospitalaria fueron el shock cardiogénico (4,5; intervalo de confianza [IC], 1,1-18) y la revascularización incompleta (odds ratio [OR] = 5,1; IC, 1-26). Tras el alta hospitalaria se siguió a 39 pacientes durante una mediana de 32 meses. La mortalidad durante el primer año de seguimiento fue del 10%. Conclusiones. El ICP es una opción terapéutica en el seno del IAM debido a enfermedad de TCI. Sin embargo, la mortalidad intrahospitalaria es elevada independientemente de la elevación del ST en el ECG y especialmente cuando se asocia a shock cardiogénico y no se logra una revascularización completa (AU)

Introduction and objectives. Percutaneous coronary intervention (PCI) for unprotected left main coronary artery (LMCA) disease may be essential following acute myocardial infarction (AMI). However, few data are available on the use of emergency PCI in unprotected LMCAs outside of clinical trials. The objective of this study was to determine the frequency of in-hospital mortality, its predictors and its association with cardiogenic shock, and long-term outcomes in patients with unprotected LMCA disease who undergo emergency PCI because of AMI. Methods. The study included 71 consecutive patients who underwent emergency angioplasty of the LMCA and who were followed up clinically. Results. Overall, 42 patients (59%) had ST-elevation AMI and 47 (66%) had cardiogenic shock or developed it during PCI. Eleven patients (16%) died in the catheterization laboratory and 33 (47%) died during hospitalization. Inhospital mortality was similar in those with and without evidence of ST-segment elevation on ECG (48% vs. 45%; P=1). Multivariate analysis showed that the predictors of in-hospital mortality were cardiogenic shock (odds ratio [OR]=4.5; 95% confidence interval [CI], 1.1-18) and incomplete revascularization (OR=5.1; 95% CI, 1.0-26). After discharge, 39 patients were followed up for a median of 32 months. Mortality in the first year was 10%. Conclusions. Emergency PCI is a viable therapeutic option for AMI due to unprotected LMCA disease. However, in-hospital mortality is high, regardless of ST-segment elevation, particularly if there is cardiogenic shock or complete revascularization has not been achieved (AU)

[In-hospital and long-term mortality in women with acute myocardial infarction treated by primary angioplasty]. / Mortalidad a corto y largo plazo en mujeres con infarto de miocardio tratado con angioplastia primaria.

INTRODUCTION AND OBJECTIVES: Mortality and morbidity after ST-elevation myocardial infarction (STEMI) are higher in women than men. It is not clear whether reperfusion by elective treatment with primary angioplasty can improve the poor prognosis in women with this condition. The objective of this study was to determine the effect of sex on clinical characteristics, and on in-hospital and long-term outcomes in patients with STEMI undergoing reperfusion by primary angioplasty. METHODS: A prospective observational study was performed in 838 consecutive patients with STEMI treated by primary angioplasty at a single hospital. Of these, 183 (22%) were women. RESULTS: Women were older (70 years vs 62 years; P<.01), were less frequently smokers (8% vs 53%; P<.01), more frequently had diabetes (45% vs 27%; P<.01) or hypertension (59% vs 36%; P<.01), presented later for angioplasty (4.1 h vs 3.6 h; P=.05), and experienced cardiogenic shock more frequently during the procedure (21% vs 12%; P<.01). There were no differences in the culprit vessel most often responsible for the infarction, in the procedural success rate, or in stent or glycoprotein IIb/IIIa inhibitor use. The total in-hospital mortality rate was higher in women (22% vs 9%; P<.01), as was the adjusted in-hospital rate (odds ratio 2.5, 95% confidence interval 1.2-5.2). During long-term follow-up after discharge (median 35.4 months), there was no significant difference in age-adjusted survival rate (relative risk 1.2, 95% confidence interval 0.7-1.9). CONCLUSIONS: Despite recent advances in the treatment of STEMI, women experience greater in-hospital mortality, even after adjustment for baseline clinical characteristics. However, the long-term age-adjusted mortality rate in women discharged from hospital was similar to that in men.

Mortalidad a corto y largo plazo en mujeres con infarto de miocardio tratado con angioplastia primaria / In-hospital and long-term mortality in women with acute myocardial infarction treated by primary angioplasty

Introducción y objetivos. Las mujeres presentan, con respecto a los varones, una mayor mortalidad y morbilidad tras un infarto agudo de miocardio con elevación del segmento ST (IAMEST). Hay controversia sobre si la angioplastia primaria (ACTPp) como tratamiento de elección logra contrarrestar el peor pronóstico de las mujeres en esta situación. El objetivo fue determinar la influencia del sexo en las características clínicas y en el pronóstico intrahospitalario y a largo plazo de un grupo de pacientes con IAMEST tratados con ACTPp como método de reperfusión. Métodos. Estudio observacional prospectivo de una cohorte de 838 pacientes consecutivos, de ellos 183 (22%) mujeres, con IAMEST tratados con ACTPp en un único centro. Resultados. Las mujeres fueron mayores (70 frente a 62 años; p < 0,01), menos fumadoras (el 53 frente al 8%; p < 0,01), más diabéticas (el 45 frente al 27%; p < 0,01), hipertensas (el 59 frente al 36%; p < 0,01), se presentaron con mayor retraso (el 4,1 frente al 3,6 h; p = 0,05) y más shock cardiogénico durante el procedimiento (del 21 frente al 12%; p = 0,01). No hubo diferencias en la arteria causante del IAM, en el éxito angiográfico o en el uso de stents o inhibidores de la glucoproteína IIb/IIIa. La mortalidad intrahospitalaria fue mayor en las mujeres, tanto en el análisis bruto (el 22 frente al 9%; p < 0,01) como en el multivariable (odds ratio = 2,5; intervalo de confianza [IC] del 95%, 1,2-5,2). En el seguimiento clínico a largo plazo (mediana de 35,4 meses) no hubo diferencias en los supervivientes tras el alta tras ajustar por la edad (riesgo relativo = 1,2; IC del 95%, 0,7-1,9). Conclusiones. A pesar de los recientes avances en el tratamiento del IAMEST, las mujeres presentan una mayor mortalidad hospitalaria ajustada por características basales. Las mujeres supervivientes tras el alta hospitalaria tuvieron una similar mortalidad a largo plazo cuando se ajustó por la edad

Introduction and objectives. Mortality and morbidity after ST-elevation myocardial infarction (STEMI) are higher in women than men. It is not clear whether reperfusion by elective treatment with primary angioplasty can improve the poor prognosis in women with this condition. The objective of this study was to determine the effect of sex on clinical characteristics, and on in-hospital and long-term outcomes in patients with STEMI undergoing reperfusion by primary angioplasty. Methods. A prospective observational study was performed in 838 consecutive patients with STEMI treated by primary angioplasty at a single hospital. Of these, 183 (22%) were women. Results. Women were older (70 years vs 62 years; P<.01), were less frequently smokers (8% vs 53%; P<.01), more frequently had diabetes (45% vs 27%; P<.01) or hypertension (59% vs 36%; P<.01), presented later for angioplasty (4.1 h vs 3.6 h; P=.05), and experienced cardiogenic shock more frequently during the procedure (21% vs 12%; P<.01). There were no differences in the culprit vessel most often responsible for the infarction, in the procedural success rate, or in stent or glycoprotein IIb/IIIa inhibitor use. The total in-hospital mortality rate was higher in women (22% vs 9%; P<.01), as was the adjusted in-hospital rate (odds ratio 2.5, 95% confidence interval 1.2-5.2). During long-term follow-up after discharge (median 35.4 months), there was no significant difference in age-adjusted survival rate (relative risk 1.2, 95% confidence interval 0.7-1.9). Conclusions. Despite recent advances in the treatment of STEMI, women experience greater in-hospital mortality, even after adjustment for baseline clinical characteristics. However, the long-term age-adjusted mortality rate in women discharged from hospital was similar to that in men

[Early heart rate increase does not predict the result of the head-up tilt test potentiated with nitroglycerin]. / El incremento temprano de la frecuencia cardíaca no predice el resultado de la prueba de basculación potenciada con nitroglicerina.

INTRODUCTION AND OBJECTIVES: The magnitude of the change in heart rate during the first few minutes of the head-up tilt test has been used to predict the test's result. The aim of this study was to investigate whether the heart rate increase during the head-up tilt test potentiated with nitroglycerin is related to the development of syncope. PATIENTS AND METHOD: The study included 158 consecutive patients with syncope, with stable sinus rhythm, and without structural cardiac disease who were undergoing a head-up tilt test with nitroglycerin. The heart rate increment induced by the tilt maneuver and by nitroglycerin administration was calculated, and its relationship to clinical variables and to the test's results was analyzed. RESULTS: The head-up tilt test gave positive results in 117 patients (74%). The heart rate was 68.7 (11.3) bpm in the decubitus position and 85.1 (15.4) bpm during the first 6 min of tilting. There was strong inverse correlation between the heart rate increase induced by tilting and age (r=--0.63; P<.001), but the increase (16.8 [9.3] bpm in patients with syncope versus 14.9 [11.3] bpm in those without; P=.3) did not predict the result of the test. The heart rate increase induced by nitroglycerin was also similar for patients with and without syncope during the pharmacologic phase of the test (27.3 [12.6] bpm and 26.7 (13.4) bpm, respectively; P=.8). CONCLUSIONS: The magnitude of the heart rate increase during the first few minutes of tilt-testing and after nitroglycerin administration is inversely related to age but does not predict the result of the head-up tilt test with nitroglycerin.

El incremento temprano de la frecuencia cardíaca no predice el resultado de la prueba de basculación potenciada con nitroglicerina / Early heart rate increase does not predict the result of the head-up tilt test potentiated with nitroglycerin

Introducción y objetivos. El incremento acentuado de la frecuencia cardíaca en los primeros minutos de la prueba de basculación ha sido utilizado como predictor del resultado final de ésta, en protocolos sin potenciación farmacológica o con isoproterenol. El objetivo del estudio es evaluar si este incremento se relaciona con la aparición de síncope durante la prueba de basculación potenciada con nitroglicerina. Pacientes y método. Análisis retrospectivo de 158 pacientes consecutivos sometidos a prueba de basculación potenciada con nitroglicerina por síncope, sin cardiopatía y en ritmo sinusal. Se calculó el incremento de la frecuencia cardíaca secundario a la basculación y el debido a la nitroglicerina, relacionándolos con las variables clínicas y el resultado de la prueba. Resultados. La prueba de basculación fue positiva en117 pacientes (74%). La frecuencia cardíaca pasó de68,7 ± 11,3 lat/min en decúbito a 85,1 ± 15,4 lat/min en los primeros 6 min pos-basculación. El incremento de frecuencia presentó una fuerte correlación negativa con la edad (r = -0,63; p < 0,001), pero no se relacionó significativamente con el resultado (16,8 ± 9,3 lat/min en el grupo con prueba positiva frente a 14,9 ± 11,3 en el negativo; p = 0,3). El aumento de la frecuencia cardíaca inducido por la nitroglicerina (27,3 ± 12,6 y 26,7 ± 13,4lat/min, respectivamente; p = 0,8) tampoco predijo el resultado del test durante la fase farmacológica. Conclusiones. Los incrementos de frecuencia cardíaca en los primeros minutos después de la basculación y la administración del fármaco se relacionan fundamentalmente con la edad y no tienen utilidad para predecir el resultado de la prueba de basculación potenciada con nitroglicerina (AU)

Introduction and objectives. The magnitude of the change in heart rate during the first few minutes of the head-up tilt test has been used to predict the test’s result. The aim of this study was to investigate whether the heart rate increase during the head-up tilt test potentiated with nitroglycerin is related to the development of syncope. Patients and method. The study included 158 consecutive patients with syncope, with stable sinus rhythm, and without structural cardiac disease who were undergoing a head-up tilt test with nitroglycerin. The heart rate increment induced by the tilt maneuver and by nitroglycerin administration was calculated, and its relationship to clinical variables and to the test’s results was analyzed. Results. The head-up tilt test gave positive results in117 patients (74%). The heart rate was 68.7 (11.3) bpm in the decubitus position and 85.1 (15.4) bpm during the first 6 min of tilting. There was strong inverse correlation between the heart rate increase induced by tilting and age (r = -0.63; P<.001), but the increase (16.8 [9.3] bp min patients with syncope versus 14.9 [11.3] bpm in those without; P=.3) did not predict the result of the test. The heart rate increase induced by nitroglycerin was also similar for patients with and without syncope during the pharmacologic phase of the test (27.3 [12.6] bpm and 26.7(13.4) bpm, respectively; P=.8). Conclusions. The magnitude of the heart rate increase during the first few minutes of tilt-testing and after nitroglycerin administration is inversely related to age but does not predict the result of the head-up tilt test with nitroglycerin (AU)

[Effect of time elapsed from spontaneous syncope on the diagnostic performance of the head-up tilt table test]. / Efecto del tiempo transcurrido tras el síncope sobre el rendimiento diagnóstico de la prueba de basculación.

OBJECTIVES: The propensity for spontaneous and tilt-induced neurocardiogenic syncope may exhibit temporal variations. Therefore the diagnostic performance of the head-up tilt test could be improved if it were performed soon after the occurrence of spontaneous syncope. The objective of this study was to assess whether the time interval between the last syncopal episode and tilt table testing influenced the outcome of the test. PATIENTS AND METHOD: Three hundred and fifteen patients undergoing diagnostic tilt table testing potentiated with nitroglycerin for suspected neurocardiogenic syncope were included in the study. The time between the last spontaneous syncope and the tilt table test was recorded and its relationship with the results of the test was analyzed. RESULTS: The tilt table test was positive in 211 patients (67.0%). The time from syncope to test was similar for patients with positive and negative tilt table test results: 28 (1-500) vs 32 (2-700) days (NS). No significant relation was observed between the results of the test and the occurrence of spontaneous syncope during the week, the month or the three months previous to the procedure. However, in men and in patients older than 50 years a higher rate of positive tests was observed if the tilt test was performed within the first month after the last spontaneous syncope. CONCLUSIONS: The time from the last previous spontaneous syncope to the head-up tilt test does not have a significant impact on test outcome in the overall population with suspected neurocardiogenic syncope. However, the rate of positivity might decrease in men and patients older than 50 years if the test is performed later than one month after the spontaneous syncopal episode.

Efecto del tiempo transcurrido tras el síncope sobre el rendimiento diagnóstico de la prueba de basculación / Effect of time elapsed from spontaneous syncope on the diagnostic performance of the head-up tilt table test

Introducción y objetivos. La propensión a sufrir síncopes neuromediados parece modificarse con el tiempo, por lo que el rendimiento diagnóstico de la prueba de basculación podría mejorar si se efectúa pronto tras el episodio sincopal. El objetivo del estudio es determinar si el tiempo transcurrido desde el síncope espontáneo hasta la realización de la prueba de basculación modifica la tasa de positividad de la misma. Pacientes y método. Se incluye a 315 pacientes a los que se practicó una prueba de basculación diagnóstica potenciada con nitroglicerina por sospecha de síncope vasovagal. Se registró el tiempo desde el síncope hasta la realización de la prueba y se analizó su relación con el resultado de la misma. Resultados. La basculación fue positiva en 211 pacientes (67,0 por ciento). El tiempo síncope-basculación fue similar en los pacientes con resultado positivo y negativo (28 [1-500] frente a 32 [2-720] días; NS). Globalmente, no existió una relación significativa entre el resultado de la prueba y la existencia de síncope durante la semana, el mes o los 3 meses previos. Sin embargo, en los varones y en mayores de 50 años, la tasa de positividad fue mayor en los pacientes con un tiempo síncope-basculación inferior a un mes. Conclusiones. El tiempo transcurrido desde el último síncope espontáneo no afecta significativamente el resultado del test de basculación en una población global evaluada para diagnóstico de síncope, pero la tasa de positividad puede disminuir en varones y en mayores de 50 años si la prueba se efectúa después de un mes del último síncope (AU)