ABSTRACT
Candida spp. vertebral osteomyelitis is rare. Clinical presentation is unspecific. Diagnosis requires mycological culture of a biopsy specimen. Therapeutic management is based on prolonged course of azole or liposomal amphotericin B. We report the case of Candida tropicalis vertebral osteomyelitis with epidural involvement in a 27 years-old male patient, followed for S-ß-thalassemia and with a history of candidemia. The fungus was isolated from a needle biopsy of the vertebral disk. The outcome was favorable under antifungal treatment by amphotericin B and voriconazole.
Subject(s)
Candida tropicalis/isolation & purification , Candidemia/complications , Osteomyelitis/etiology , Adult , Amphotericin B/therapeutic use , Antifungal Agents/therapeutic use , Humans , Male , Voriconazole/therapeutic useABSTRACT
In this prospective study, we assessed the incidence of central venous catheter (CVC)-related thrombosis in haematopoietic stem cell transplant (HSCT) recipients. We determined the contribution of inherited prothrombotic abnormalities in blood coagulation to CVC-related thrombosis in these patients. The study was conducted between May 2002 and September 2004. CVCs were externalized, nontunneled, polyurethane double lumen catheters. Before catheter insertion, laboratory prothrombotic markers included factor V Leiden, the prothrombin gene Gly20210A mutation, plasma antithrombin levels, and protein C and S activity. All patients were systematically examined by ultrasonography just before, or <24 h after, catheter removal, and in case of clinical signs of thrombosis. A total of 171 patients were included during the 28-month study period. Five (2.9%) and three (1.7%) patients had evidence of protein C and protein S deficiency, respectively. Only one patient had an antithrombin deficiency (0.6%). In total, 10 patients (5.8%) were heterozygous for the factor V Leiden mutation, and one patient had heterozygous prothrombin G20210A mutation (0.6%). We observed a CVC-related thrombosis in 13 patients (7.6%). Thrombosis was diagnosed in four out of 20 patients (20%) with a inherited prothrombotic abnormality compared to nine of 151 patients (6%) who did not have a thrombophilic marker (relative risk 3.3 CI 95% 1.1-9.9). Our results suggest that inherited prothrombotic abnormalities contribute substantially to CVC-related thrombosis in HSCT recipients. In view of physicians' reluctance to prescribe prophylactic anticoagulant treatment in these patients, a priori determination of inherited prothrombotic abnormalities may form a basis to guide these treatment decisions.
Subject(s)
Catheterization, Central Venous/adverse effects , Hematopoietic Stem Cell Transplantation/adverse effects , Thrombophilia/complications , Thrombosis/etiology , Blood Coagulation Factors/genetics , Catheterization/adverse effects , Family Health , Female , Genetic Predisposition to Disease , Humans , Male , Middle Aged , Prevalence , Prospective Studies , Thrombophilia/diagnosis , Thrombophilia/geneticsABSTRACT
The case of a seven-year-old with multifocal (type II) Langheran's cell histiocytosis since the age of two years is reported. Despite therapy, biliary cirrhosis with portal hypertension developed gradually. Histologic studies of liver biopsy specimens, computed tomography, and transhepatic cholangiography disclosed dilatation of the bile ducts, suggesting sclerosing cholangitis, a specific complication of Langherans' cell histiocytosis which precipitates the development of biliary cirrhosis.
Subject(s)
Cholangitis, Sclerosing/diagnostic imaging , Histiocytosis, Langerhans-Cell/complications , Biopsy , Child , Cholangiography , Cholangitis, Sclerosing/etiology , Cholangitis, Sclerosing/pathology , Humans , Hypertension, Portal/etiology , Liver Cirrhosis/etiology , Male , Tomography, X-Ray ComputedABSTRACT
In a patient with disk herniation it is often difficult to establish that the disk is free in the spinal canal. A retrospective medical record study comparing 65 cases of free herniated disk (FHD) confirmed upon surgery and 65 cases of disk protrusion (DP) demonstrated that FHD was more common in young male blue collar workers, especially those who worked in the sitting position. No clinical findings were diagnostic of FHD although the straight-leg raising test was positive at smaller angles than in disk protrusion. In this study, sensitivity and specificity of CT scan for the diagnosis of FHD were 75% and 80%, respectively. CT scan findings suggestive of FHD included a free disk fragment, found in 22.5% of cases, and an acute connecting angle. Saccoradiculography was more sensitive but less specific than CT scan in this study. In FDH, migration was common and ragged hernia contours were seen on the saccoradiculography images.
Subject(s)
Intervertebral Disc Displacement/diagnosis , Adult , Female , Humans , Intervertebral Disc Displacement/diagnostic imaging , Intervertebral Disc Displacement/epidemiology , Male , Myelography , Retrospective Studies , Spinal Nerve Roots/diagnostic imaging , Tomography, X-Ray ComputedSubject(s)
Hyperprolactinemia/etiology , Hypothyroidism/complications , Pituitary Neoplasms/etiology , Prolactinoma/etiology , Adult , Diagnosis, Differential , Female , Humans , Hyperprolactinemia/genetics , Hypothyroidism/genetics , Pituitary Neoplasms/diagnosis , Pituitary Neoplasms/genetics , Prolactinoma/diagnosis , Prolactinoma/geneticsABSTRACT
The authors report a new case of chondrosarcoma of the mandible in a 24 year-old female patient. They insist on the rareness of this entity and on the difficulties in establishing this diagnosis from the clinical, radiological and pathological points of view. Elements of prognosis are discussed through a review of the literature.
