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Incidence of aspirin nonresponsiveness using the Ultegra Rapid Platelet Function Assay-ASA.

Wang, John C; Aucoin-Barry, Denise; Manuelian, Deborah; Monbouquette, Rachele; Reisman, Mark; Gray, William; Block, Peter C; Block, Elizabeth H; Ladenheim, Marc; Simon, Daniel I.

Am J Cardiol ; 92(12): 1492-4, 2003 Dec 15.

Article in English | MEDLINE | ID: mdl-14675598

ABSTRACT

We report the incidence of aspirin nonresponsiveness in a prospective, multicenter registry (n=422 patients) to be 23% using the Ultegra Rapid Platelet Function Assay-ASA, and determined a history of coronary artery disease to be associated with twice the odds of being an aspirin nonresponder (odds ratio 2.01, 95% confidence interval 1.189 to 3.411, p=0.009). Further prospective studies are needed to correlate aspirin nonresponsiveness to adverse clinical events.

Subject(s)

Aspirin/therapeutic use , Coronary Artery Disease/drug therapy , Drug Resistance , Platelet Aggregation Inhibitors/therapeutic use , Coronary Artery Disease/blood , Coronary Artery Disease/complications , Female , Hematocrit , Humans , Incidence , Logistic Models , Male , Middle Aged , Odds Ratio , Platelet Count , Platelet Function Tests/methods , Predictive Value of Tests , Prospective Studies , Registries

ABSTRACT

Subject(s)

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