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1.
PLoS One ; 16(1): e0245689, 2021.
Article in English | MEDLINE | ID: mdl-33471827

ABSTRACT

INTRODUCTION: Self-reported levels of disability in individuals with low back pain (LBP) have not improved in the last decade. A broader perspective and a more comprehensive management framework may improve disability outcomes. We recently developed and validated the Low Back Pain and Disability Drivers Management (PDDM) model, which aims to identify the domains driving pain and disability to guide clinical decisions. The objectives of this study were to determine the applicability of the PDDM model to a LBP population and the feasibility of conducting a pragmatic trial, as well as to explore clinicians' perceived acceptability of the PDDM model's use in clinical settings. METHODS: This study was an one-arm prospective feasibility trial. Participants included physiotherapists working with a population suffering from LBP and their patients aged 18 years or older presenting with a primary complaint of LBP that sought a new referral and deemed fit for rehabilitation from private and public clinical settings. Clinicians participated in a one-day workshop on the integration of the PDDM model into their clinical practice, and were asked to report various LBP-related outcomes via self-reported questionnaires (i.e., impact of pain on physical function, nervous system dysfunctions, cognitive-emotional factors, work disabilities) at baseline and at six-week follow-up. Physiotherapists' acceptability of the use of the PDDM model and appreciation of the training were assessed via semi-structured phone interviews. Analyses focused on a description of the model's applicability to a LBP population, feasibility outcomes and acceptability measures. RESULTS: Applicablity of the PDDM model was confirmed since it successfully established the profile of patients according to the elements of each categories, and each of the 5 domains of the model was represented among the study sample. Trial was deemed feasible contingent upon few modifications as our predefined success criteria for the feasibility outcomes were met but feasibility issues pertaining to data collection were highlighted. Twenty-four (24) clinicians and 61 patients were recruited within the study's timeframe. Patient's attrition rate (29%) and clinicians' compliance to the study protocol were adequate. Clinicians' perceived acceptability of the use of the model in clinical settings and their appreciation of the training and online resources were both positive. Recommendations to improve the model's integration in clinical practice, content of the workshop and feasibility of data collection methods were identified for future studies. A positive effect for all patients' reported outcome measures were also observed. All outcome measures except for the PainDetect questionnaire showed a statistically significant reduction post-intervention (p<0.05). CONCLUSION: These findings provide preliminary evidence of the potential of the PDDM model to optimize LBP management as well as conducting a future larger-scale pragmatic trial to determine its effectiveness. TRIAL REGISTRATION: Clinicaltrial.gov: NCT03949179.


Subject(s)
Exercise Therapy , Low Back Pain/therapy , Models, Theoretical , Pain Management , Quality of Life , Adult , Feasibility Studies , Female , Humans , Low Back Pain/physiopathology , Male , Middle Aged , Prospective Studies
2.
Qual Res Med Healthc ; 5(2): 9174, 2021 Oct 05.
Article in English | MEDLINE | ID: mdl-37441669

ABSTRACT

Parents of children suffering from a life-limiting medical condition struggle with difficult existential questions. Our objective was to understand why those parents' interactions with the medical world were so different, ranging from hostile to collaborative, with the themes of identity, spirituality and serenity. A grounded theory design based on the narrative identity framework was used to interview sixteen parents. Three categories emerged: i) Parents in the Almighty category delegate all their power to God or medicine and are the most suffering parents as they do not author their life; ii) Parents in the Me category make every decision on their own causing much anxiety, and they become rebarbative to the medical world; iii) Parents in the Guide category take advice from others, while remaining the authors of their stories and are the most serene parents. Understanding and recognizing these categories can have a major impact on communication with those families.

3.
Pain Manag Nurs ; 21(6): 488-494, 2020 12.
Article in English | MEDLINE | ID: mdl-32631762

ABSTRACT

BACKGROUND: Although pain undeniably has negative consequences, pain management often remains suboptimal, particularly in the pediatric population in the emergency room (ER). AIM: In this observational study using qualitative and quantitative methods, we investigated everyday adherence to current nursing best-practice pediatric guidelines in the ER paying particular attention to the interaction between children, parents, and nurses. METHODS: An adapted version of the nursing observation tool for pain management was used to describe pediatric pain management provided by nurses caring for children (0-14 years old) admitted to the ER. We also assessed child-parent-nurse interactions. (The aim of the study was presented to the nurses as part of the survey on interactions without specifying the focus on pain management.) RESULTS: Forty-seven children were included (91 painful episodes) during the observation period (112 hours). There was a screening for pain in 55% of cases, and pain scales were used in 10% of cases. Analgesic treatments were administered in 75% of cases (procedural or disease-related pain). Follow-up evaluations were performed in 19% of cases. Nonpharmacologic approaches were scarcely used. The use of both helpful and nonhelpful languages were noted during interactions with children and parents. Parents' collaboration was rarely requested to help relieve their child's pain. CONCLUSIONS: Our results show that pediatric pain management in the ER could be optimized. Parents are still not considerably involved in their child's pain management. Parents' involvement could contribute to improving pediatric pain management.


Subject(s)
Emergency Service, Hospital/standards , Pain Management/standards , Adolescent , Child , Child, Preschool , Emergency Service, Hospital/organization & administration , Female , Humans , Infant , Male , Pain Management/methods , Pain Measurement/methods , Pediatrics/instrumentation , Pediatrics/methods , Pediatrics/standards , Surveys and Questionnaires
4.
Pediatr Exerc Sci ; 31(4): 425-431, 2019 11 01.
Article in English | MEDLINE | ID: mdl-31043128

ABSTRACT

PURPOSE: To evaluate exercise-induced analgesia (EIA) effectiveness in healthy adolescent males and to investigate possible associations between EIA and physiological/psychological variables. METHODS: Twenty-eight healthy adolescent males (14-17 y) participated in this study. EIA was evaluated by comparing perceptions of heat pain stimulations before and after an increasing maximal load test on a cycle ergometer (VO2max). RESULTS: Pain intensity for mild and strong heat pain stimulations significantly decreased following physical exercise (mild: EIA = 28.6%; 95% confidence interval, 0.9-1.9; P < .001 and strong: EIA = 11.3%; 95% confidence interval, 0.3-1.4; P = .002). The number of physical activity hours per week was positively correlated with the effectiveness of EIA for mild and strong pain intensity (r = .41, P = .03 and r = .43, P = .02, respectively). CONCLUSIONS: Intense physical exercise decreases perception of intensity of experimental heat pain in healthy adolescent males. The least physically active adolescents have reduced EIA effectiveness to experimental heat pain stimulations compared with physically active ones. Adolescents adopting an active lifestyle have more endogenous pain inhibition and could, therefore, potentially be less disposed to suffer from chronic pain later in life.


Subject(s)
Adolescent Behavior , Analgesia/methods , Exercise , Pain Perception/physiology , Pain Threshold , Sedentary Behavior , Adolescent , Adolescent Behavior/physiology , Adolescent Behavior/psychology , Exercise/physiology , Exercise/psychology , Exercise Test , Healthy Volunteers , Humans , Male , Pain Measurement , Pain Threshold/physiology , Pain Threshold/psychology
5.
J Sports Sci ; 37(11): 1265-1269, 2019 Jun.
Article in English | MEDLINE | ID: mdl-30543316

ABSTRACT

The purpose of this study was to identify which averaging methods most accurately measures peak cardiorespiratory fitness (CRF) parameters [peak O2 uptake (VO2), peak O2pulse and peak respiratory exchange ratio (RER)] in a sample of healthy children and adolescents. In this cross-sectional multicenter study, we recruited 278 healthy children aged 12-17 years. We compared the mean peak value of three CRF parameters using the recommended averaging methods (30-second block average) with alternative averaging methods such as moving averages or shorter smoothing periods. We also assessed averaging methods for accuracy by individually reviewing breath-by-breath scatter plots. The 30-second block average method resulted in a lower mean peak VO2 and in an increased proportion of underestimated peak values. Using a 30-second moving average significantly increased mean peak values which increased accuracy. Similar results were found for peak RER and peak O2pulse. In conclusion, the currently recommended averaging method (30-second block average) increased the risk of misinterpretation of peak CRF values in children. Using a moving average approach decreased misinterpretation and increased accuracy.


Subject(s)
Cardiorespiratory Fitness , Exercise Test/methods , Exercise Test/statistics & numerical data , Adolescent , Child , Cross-Sectional Studies , Data Interpretation, Statistical , Humans , Oxygen Consumption , Prospective Studies , Pulmonary Gas Exchange , Software
6.
Pain Res Manag ; 2018: 6375713, 2018.
Article in English | MEDLINE | ID: mdl-30344801

ABSTRACT

Objectives: The use of interdisciplinary patient-centered care (PCC) and empathetic behaviour seems to be a promising avenue to address chronic pain management, but their use in this context seems to be suboptimal. Several patient factors can influence the use of PCC and empathy, but little is known about the impact of pain visibility on these behaviours. The objective of this study was to investigate the influence of visible physical signs on caregiver's patient-centered and empathetic behaviours in chronic pain context. Methods: A convenience sample of 21 nurses and 21 physicians participated in a descriptive study. PCC and empathy were evaluated from self-assessment and observer's assessment using a video of real patients with chronic pain. Results: The results show that caregivers have demonstrated an intraindividual variability: PCC and empathetic behaviours of the participants were significantly higher for patients who have visible signs of pain (rheumatoid arthritis and complex regional pain syndrome) than for those who have no visible signs (Ehler-Danlos syndrome and fibromyalgia) (p < 0.001). Participants who show a greater difference in their patient-centered behaviour according to pain visibility have less clinical experience. Discussion: The pain visibility in chronic pain patients is an important factor contributing to an increased use of PCC and empathy by nurses and physicians, and clinical experience can influence their behaviours. Thus, pain invisibility can be a barrier to quality of care, and these findings reinforce the relevance to educating caregivers to these unconscious biases on their behaviour toward chronic pain patients.


Subject(s)
Attitude of Health Personnel , Chronic Pain , Empathy/physiology , Pain Management/methods , Patient-Centered Care/methods , Adolescent , Adult , Chronic Pain/physiopathology , Chronic Pain/psychology , Chronic Pain/therapy , Female , Humans , Male , Middle Aged , Nurses/psychology , Pain Measurement , Physicians/psychology , Young Adult
7.
Scand J Pain ; 18(4): 711-717, 2018 10 25.
Article in English | MEDLINE | ID: mdl-30007060

ABSTRACT

Background and aims Chronic pain is affecting a growing number of individuals including adolescents. Different endogenous pain inhibitory systems could confer protection against development of chronic pain. Decreased pain perception can be observed following intense pain (i.e. conditioned pain modulation - CPM) or after physical exercise (i.e. exercise-induced analgesia - EIA). Reduced effectiveness of pain inhibitory mechanisms have been reported in several chronic pain conditions. However, the extent of these dysfunctions has not been thoroughly investigated in adolescents suffering from chronic pain. Our hypothesis was that adolescents suffering from chronic pain have less effective CPM and EIA than pain-free teenagers. Methods Twenty-five healthy adolescent girls and 16 teenage girls with chronic pain participated in this study. Only girls were included in this investigation, since chronic pain is more prevalent in females. The effectiveness of CPM was assessed by comparing heat pain stimulations (individually adapted to induce mild pain intensity) performed with a thermode before and after a cold pressor test (CPT; 2 min, 10 °C). EIA was evaluated by comparing pain intensity produced by an ice cube placed on the forearm before and after a graded exercise test on a cycle ergometer. Results Pain intensity produced by heat pain stimulations decreased following CPT in healthy (p<0.05), but not in chronic pain adolescent girls (p=0.4). Pain intensity induced by the ice cube was reduced after exercise in healthy (p<0.05), but not in chronic pain adolescents (p=0.9). The effectiveness of CPM and EIA was inferior in teenage girls suffering from chronic pain compared to healthy participants (p<0.05). Conclusions Endogenous pain inhibitory mechanisms triggered by intense pain or by physical exercise are effective in healthy adolescent girls. Teenage girls living with chronic pain do not show diminished pain perception after a CPT or a graded exercise test. These results suggest that pain inhibitory mechanisms such as CPM and EIA are ineffective in adolescent girls suffering from chronic pain. Implications In a wider context, the findings of the present research could help understand better the mechanisms involved in the development of chronic pain. Improved comprehension of this subject might help prevent chronic pain conditions and thus, reduce the negative impacts of this burden.


Subject(s)
Analgesia , Chronic Pain/physiopathology , Exercise/physiology , Pain Perception/physiology , Adolescent , Cold Temperature , Female , Healthy Volunteers , Hot Temperature , Humans , Pain Measurement
9.
Pain Res Manag ; 20(4): 183-8, 2015.
Article in English | MEDLINE | ID: mdl-26069896

ABSTRACT

BACKGROUND: Chronic pain is a complex phenomenon resulting from biological, psychological and social factors, and the use of patient-centred care (PCC) appears to be a promising avenue for its treatment. Various methods have been used for measuring PCC in nurses and physicians (caregivers); however, methodological problems have been raised following the observation of real clinical encounters or standardized patient simulations. The development of new strategies is required. OBJECTIVE: To develop and validate an observation scale for the assessment of PCC in caregivers, using standardized videos of real patients with chronic pain. METHODS: An expert panel developed five videos and the Sherbrooke Observation Scale of Patient-Centered Care (SOS-PCC), which were tested in a sample of 21 nurses and 21 physicians working with chronic pain patients. The content validity, internal consistency and inter-rater reliability of the SOS-PCC were assessed. RESULTS: The expert panel was satisfied with the content validity of the SOS-PCC. Results revealed good internal consistency (Cronbach's alpha = 0.88) and inter-rater reliability (intraclass coefficient = 0.93) for this scale. CONCLUSIONS: To the authors' knowledge, the SOS-PCC is the first instrument available in French to assess PCC behaviour of caregivers using videos of real patients with chronic pain. The psychometric qualities of these instruments are good. Future studies will need to assess this instrument with other populations of caregivers.


Subject(s)
Chronic Pain/therapy , Pain Management , Patient Outcome Assessment , Patient-Centered Care , Adult , Aged , Female , Humans , Male , Middle Aged , Nurses/psychology , Observation , Physicians/psychology , Psychometrics , Reproducibility of Results , Surveys and Questionnaires , Video Recording
10.
Pain Res Treat ; 2014: 121289, 2014.
Article in English | MEDLINE | ID: mdl-24724021

ABSTRACT

Preterm birth is associated with painful procedures during the neonatal intensive care unit (NICU) stay. Full-term newborns can also experience pain, following surgery. These procedures can have long-lasting consequences. It has been shown that children born preterm show pain responses and cardiac alterations. This study aimed to explore the heart rate reactivity to pain in 107 subjects born either preterm or full-term who were between 7 and 25 years old at testing. We also evaluated the effect of pain experienced at birth, as represented by a longer NICU stay, time under ventilation, and surgery at birth. Participants were asked to immerse their right forearm in 10°C water for 2 minutes. Electrocardiograms were recorded at baseline and during the immersion procedure. Full-term subjects showed a stable increase in heart rate throughout the procedure, whereas preterm ones showed a strong increase at the beginning, which decreased over time. Also, preterm and full-term subjects who experienced pain at birth showed higher resting heart rate, stronger sympathetic activity, and lower cardiac vagal activity. Our study demonstrated a long-term impact of a long NICU stay and surgery at birth on cardiac autonomic activity. This could lead to impaired reactions to pain or stress in later life.

11.
Pain ; 155(6): 1064-1069, 2014 Jun.
Article in English | MEDLINE | ID: mdl-24345429

ABSTRACT

Fibromyalgia (FM) is a chronic widespread pain condition of unknown origin. Reduced endogenous pain inhibition could be related to high pain sensitivity in FM. Associations between conditioned pain modulation (CPM) and cardiovascular responses to pain have been observed in healthy subjects (HS). Because reduced cardiovascular reactivity to various stressors has been reported in FM patients, we investigated relationships between CPM and cardiovascular response to the cold pressor test (CPT) in 22 FM patients and 25 HS. CPM was evaluated by comparing pain intensity produced by a 120-second heat test stimulus (HTS) before and after a CPT (2minutes, 12°C). The CPT, used to activate CPM, produced greater pain intensity in FM patients. Patients with FM had higher heart rates than HS at baseline and during CPT. Higher heart rate was related with higher pain intensity during the CPT. Blood pressure increments during CPT were weaker in the FM group. CPM was less effective in FM patients than in HS. Importantly, systolic blood pressure responses during CPT were positively related to CPM effectiveness, suggesting that reduced blood pressure response during the conditioning stimulus could be involved in CPM dysfunction in the FM group. Higher heart rate could be implicated in the greater sensitivity to cold pain in FM. Patients with FM have reduced blood pressure response to a painful CPT. Reduced cardiovascular reactivity to pain could have important involvement in diminished endogenous pain inhibition efficacy and FM pathophysiology.


Subject(s)
Blood Pressure/physiology , Conditioning, Psychological/physiology , Fibromyalgia/diagnosis , Heart Rate/physiology , Pain Measurement/methods , Pain Threshold/physiology , Adult , Female , Fibromyalgia/physiopathology , Fibromyalgia/psychology , Hot Temperature/adverse effects , Humans , Male , Middle Aged , Pain Measurement/psychology , Pain Threshold/psychology
12.
Pain ; 154(8): 1377-82, 2013 Aug.
Article in English | MEDLINE | ID: mdl-23692807

ABSTRACT

Conditioned pain modulation (CPM) (ie, diffuse noxious inhibitory controls) is characterized by reduced perception of pain caused by intense pain in a remote body area. The conditioning stimuli used to trigger CPM causes pain, but also important cardiovascular responses. Higher blood pressure has been associated with reduced pain sensitivity. Descending pain inhibitory mechanisms such as CPM could be involved in this relationship. We investigated the associations between CPM and cardiovascular responses during the cold-pressor test (CPT). Heat pain threshold and tolerance were evaluated in 26 (13 men, 13 women) healthy subjects. CPM was evaluated by comparing pain intensity produced by a 120-second heat stimulation before and after a CPT (5 minutes, 7°C). Heart rate, blood pressure, and baroreflex sensitivity were monitored at rest and during CPT to evaluate cardiovascular responses. We observed a positive relationship between resting blood pressure and heat pain tolerance. The CPT caused important heart rate and blood pressure increases. CPT also reduced pain intensity during the subsequent heat pain-stimulus, indicating effective CPM. A significant positive association was observed between CPM magnitude and the increase in blood pressure during the CPT. These results show that resting blood pressure values are related to acute pain tolerance, while descending pain inhibition is associated with increases in blood pressure. The rise in blood pressure caused by the conditioning stimulus is an important factor predicting the extent of endogenous pain inhibition in healthy subjects.


Subject(s)
Baroreflex/physiology , Blood Pressure/physiology , Conditioning, Psychological/physiology , Heart Rate/physiology , Pain Perception/physiology , Pain/physiopathology , Adult , Female , Humans , Hyperalgesia/etiology , Hyperalgesia/physiopathology , Male , Pain Threshold/physiology , Physical Stimulation/adverse effects , Young Adult
13.
Clin J Pain ; 28(6): 519-26, 2012 Jul.
Article in English | MEDLINE | ID: mdl-22673485

ABSTRACT

OBJECTIVES: Past studies confirm that patients with fibromyalgia (FM) and irritable bowel syndrome (IBS) show similar pain processing dysfunctions, such as reduced pain inhibition and aberrant autonomic nervous system (ANS) responses. However, patients with FM and IBS have rarely been investigated in the same study. The aim of the present study, therefore, was to compare descending pain inhibition, pain sensitivity, and ANS reactivity to pain in FM, IBS, and healthy controls (HC). METHODS: Female patients with FM (n=10), IBS (n=13), and HCs (n=10) were exposed to multiple cold water (12°C) immersions to study pain sensitivity and descending pain inhibition. Heart rate variability was also assessed during immersions. RESULTS: Pain intensity scores were highest in FM, intermediate in IBS, and smallest in HCs. In contrast, pain inhibition was absent in FM, intermediate in IBS, and strongest in HCs. Importantly, controlling for differences in pain inhibition abolished group differences in pain sensitivity. Heart rate variability analyses confirmed that, in response to mild levels of pain, patients with FM showed greater sympathetic activity whereas HCs showed greater parasympathetic activity. Patients with IBS showed intermediate ANS responses. DISCUSSION: Our results confirm the presence of graded levels of somatic hyperalgesia across patients with IBS and FM. A similar pattern of result was observed for pain inhibitory dysfunctions. These pain processing changes were accompanied by abnormal autonomic responses, which maintained patients (principally patients with FM) in a state of sympathetic hyperactivity. Results suggest that patients with IBS and FM may present common, but graded, pain processing and autonomic dysfunctions.


Subject(s)
Autonomic Nervous System/physiopathology , Fibromyalgia/physiopathology , Irritable Bowel Syndrome/physiopathology , Pain Perception , Pain/physiopathology , Adaptation, Physiological , Adult , Female , Fibromyalgia/complications , Humans , Irritable Bowel Syndrome/complications , Male , Middle Aged , Pain/etiology
14.
Int J Pediatr ; 2012: 820209, 2012.
Article in English | MEDLINE | ID: mdl-22577402

ABSTRACT

Sedation and/or analgesia are standard of care for pediatric patients during painful intervention or medical imaging requiring immobility. Physician availability is frequently insufficient to allow for all procedural sedation. A nurse-led sedation program was created at the Centre Hospitalier Universitaire de Sherbrooke (CHUS) to address this problem. Objective. To evaluate the effectiveness and the safety of our program. Methods. A retrospective study of all the procedural sedations done over one year was performed. Complications were separated in four categories: (1) major complications (call for help; unexpected admission, aspiration, and code); (2) reportable sedation events (oxygen saturation <90%, bradycardia (more than 2 SD below normal for the age of the child), and hypotension (more than 2 SD below normal for the age of the child); (3) difficult sedation (agitation, inadequate sedation, and failure to perform the procedure), (4) minor complications. Results. 448 patients, 249 boys and 199 girls; received sedation for 555 procedures. Overall, 78% (432) of interventions were successfully accomplished: 0% of major complications, 8% of reportable sedation events; 5% of difficult sedation; 9% of minor complications. Conclusion. Our nurse-led sedation program compares favorably to other similar systems.

15.
Curr Med Res Opin ; 28(2): 245-8, 2012 Feb.
Article in English | MEDLINE | ID: mdl-22208674

ABSTRACT

Placebo effects are well-known phenomena in medicine and biology. In fact, placebos are used as control conditions in randomized cross-over clinical trials to validate new treatments. Only recently, however, has it become apparent that the conditioning and/or expectation effects provided by the experience of placebos can influence the results of clinical trials. It seems that combining shams and sequences has prejudiced the conclusions provided by cross-over designs. Frighteningly, this bias is always in the same direction, namely to increase the risk of rejecting potentially valid treatments. New models for clinical trials should be encouraged if we wish to market new and truly valid treatments.


Subject(s)
Cross-Over Studies , Placebo Effect , Placebos/administration & dosage , Randomized Controlled Trials as Topic/methods , Bias , Humans , Research Design , Transcranial Magnetic Stimulation/adverse effects
16.
Pain Med ; 10(8): 1334-40, 2009 Nov.
Article in English | MEDLINE | ID: mdl-19671085

ABSTRACT

OBJECTIVE: Slow deep breathing has been proposed as an effective method to decrease pain. However, experimental studies conducted to validate this claim have not been carried out. DESIGN: We measured thermal pain threshold and tolerance scores from 20 healthy adults during five different conditions, namely, during natural breathing (baseline), slow deep breathing (6 breaths/minute), rapid breathing (16 breaths/minute), distraction (video game), and heart rate (HR) biofeedback. We measured respiration (rate and depth) and HR variability from the electrocardiogram (ECG) output and analyzed the effects of respiration on pain and HR variability using time and frequency domain measures of the ECG. RESULTS: Compared with baseline, thermal pain threshold was significantly higher during slow deep breathing (P = 0.002), HR biofeedback (P < 0.001), and distraction (P = 0.006), whereas thermal pain tolerance was significantly higher during slow deep breathing (P = 0.003) and HR biofeedback (P < 0.001). Compared with baseline, only slow deep breathing and HR biofeedback conditions had an effect on cardiac activity. These conditions increased the amplitude of vagal cardiac markers (peak-to-valley, P < 0.001) as well as low frequency power (P < 0.001). CONCLUSION: Slow deep breathing and HR biofeedback had analgesic effects and increased vagal cardiac activity. Distraction also produced analgesia; however, these effects were not accompanied by concomitant changes in cardiac activity. This suggests that the neurobiology underlying respiratory-induced analgesia and distraction are different. Clinical implications are discussed, as are the possible cardiorespiratory processes responsible for mediating breathing-induced analgesia.


Subject(s)
Biofeedback, Psychology/physiology , Breathing Exercises , Heart Rate/physiology , Hyperalgesia/therapy , Pain Management , Respiratory Physiological Phenomena , Adult , Analgesia/methods , Attention/physiology , Biofeedback, Psychology/methods , Female , Heart Conduction System/physiology , Humans , Hyperalgesia/physiopathology , Hyperalgesia/psychology , Male , Pain/physiopathology , Pain/psychology , Pain Measurement/methods , Pain Threshold/physiology , Pain Threshold/psychology , Photic Stimulation/methods , Psychophysiology , Treatment Outcome , Vagus Nerve/physiology , Young Adult
17.
Eur J Pain ; 12(7): 945-51, 2008 Oct.
Article in English | MEDLINE | ID: mdl-18308597

ABSTRACT

Prematurity is known to affect the development of various neurophysiological systems, including the maturation of pain and cardiac circuits. The purpose of this study was to see if numerous painful interventions, experienced soon after birth, affect counterirritation-induced analgesia (triggered using the cold pressor test) later in life. A total of 26 children, between the ages of 7 and 11 participated in the study. Children were divided into three groups, according to their birth status (i.e., term-born, born preterm and exposed to numerous painful interventions, or born preterm and exposed to few painful interventions). Primary outcome measures were heat pain thresholds, heat sensitivity scores, and cardiac reactivity. Results showed that preterm children and term-born children had comparable pain thresholds. Exposure to conditioning cold stimulation significantly increased heart rate and significantly decreased the thermal pain sensitivity of term-born children. These physiological reactions were also observed among preterm children who were only exposed to a few painful interventions at birth. Changes in heart rate and pain sensitivity in response to conditioning cold stimulation were not observed in preterm children that had been exposed to numerous painful procedures during the neonatal period. These results suggest that early pain does not lead to enhanced pain sensitivity when premature babies become children, but that their endogenous pain modulatory mechanisms are not as well developed as those of children not exposed to noxious insult at birth. Greater frequency of painful procedures also dampened the rise in heart rate normally observed when experimental pain is experienced.


Subject(s)
Afferent Pathways/physiopathology , Infant, Premature, Diseases/physiopathology , Intensive Care, Neonatal , Pain Threshold/physiology , Pain/physiopathology , Afferent Pathways/growth & development , Child , Cold Temperature/adverse effects , Diagnostic Tests, Routine/adverse effects , Enteral Nutrition/adverse effects , Female , Heart Rate , Hot Temperature/adverse effects , Humans , Infant, Newborn , Infant, Premature , Infant, Premature, Diseases/diagnosis , Infant, Premature, Diseases/therapy , Injections/adverse effects , Length of Stay/statistics & numerical data , Male , Pain/etiology , Respiration, Artificial/adverse effects , Respiration, Artificial/statistics & numerical data
18.
J Otolaryngol Head Neck Surg ; 37(2): 279-84, 2008 Apr.
Article in English | MEDLINE | ID: mdl-19128627

ABSTRACT

INTRODUCTION: Tonsillectomy is usually done as day surgery, transferring to the parents most of the postoperative care. They often feel alone and incompetent in front of a child in pain. We developed a guide to help parents for both the evaluation and the management of postoperative pain. OBJECTIVE: To improve pediatric posttonsillectomy pain management with the implementation of a parental guide and treatment algorithm. METHODS: Eighty children (5-17 years) were recruited in this randomized clinical trial. Parents and children were assigned to one of the research groups: control or experimental. All received an identical prescription for acetaminophen (15 mg/kg) and morphine (0.3 mg/kg), information about the medication, a visual analogue scale (VAS), and index cards to be filled at home. The experimental group also received a treatment algorithm associating pain scores with analgesics. RESULTS: Pain scores for the control group and the experimental group were 5.3 and 4.7 on the day of surgery, 4.0 and 3.6 the next day, 2.2 and 2.3 3 days later, and 1.6 and 1.4 1 week after the intervention, respectively. The side effects and the analgesics given were comparable for both groups. CONCLUSION: No significant difference was demonstrated for the studied parameters, probably because the majority of the parents followed the prescriptions well. The guide was much appreciated. The children understood the VAS easily and liked using it. The combination of acetaminophen-morphine needs to be revisited since pain remains problematic.


Subject(s)
Acetaminophen/therapeutic use , Ambulatory Surgical Procedures , Analgesics, Opioid/therapeutic use , Analgesics/therapeutic use , Morphine/therapeutic use , Pain Measurement , Pain, Postoperative/drug therapy , Tonsillectomy , Acetaminophen/adverse effects , Adolescent , Algorithms , Analgesics/adverse effects , Analgesics, Opioid/adverse effects , Child , Child, Preschool , Dose-Response Relationship, Drug , Drug Administration Schedule , Drug Therapy, Combination , Female , Humans , Male , Morphine/adverse effects , Parents/education
19.
J Otolaryngol ; 36(5): 264-9, 2007 Oct.
Article in English | MEDLINE | ID: mdl-17963664

ABSTRACT

INTRODUCTION: Although we routinely use morphine at our institution, moderate to severe pain often persists for several days after tonsillectomy. Nonsteroidal anti-inflammatory drugs could offer significant relief. Unfortunately, concerns about increased risk of bleeding limit their use. Selective inhibitors of cyclooxygenase type 2 (COX-2), such as rofecoxib, which do not affect bleeding time, could be an interesting option. OBJECTIVE: To evaluate the efficiency and safety of "rofecoxib-morphine" versus "acetaminophen-morphine" for post-tonsillectomy pain control. METHOD: Eighty children (5-17 years old) took part in this prospective comparative study. Forty children were in the acetaminophen-morphine group (group A), and the remaining 40 children were in the rofecoxib-morphine group (group R). Pain scores, administered doses of medication, side effects, and the general health status of the child were collected by telephone calls made on the first, third, and seventh days after surgery. RESULTS: Pain scores for group A compared with group R are as follows: day 0 at home arrival, 4.6 to 2.5; day 0 average, 4.7 to 3.3; day 1, 3.6 to 2.6; day 3, 2.3 to 1.4; and day 7, 1.4 to 2.0. Moreover, children who received rofecoxib generally drank, ate, and returned to their regular activities more quickly than the children of group A. No side effects were reported with rofecoxib. CONCLUSION: Rofecoxib (COX-2 inhibitor) significantly reduces pain scores after pediatric tonsillectomy. The combination of rofecoxib and morphine is safe and helps children return more quickly to their activities.


Subject(s)
Acetaminophen/administration & dosage , Analgesics, Opioid/administration & dosage , Cyclooxygenase 2 Inhibitors/administration & dosage , Lactones/administration & dosage , Morphine/administration & dosage , Pain, Postoperative/drug therapy , Sulfones/administration & dosage , Tonsillectomy/adverse effects , Adolescent , Child , Child, Preschool , Drug Therapy, Combination , Female , Humans , Male , Pain Measurement , Pain, Postoperative/etiology
20.
Pediatrics ; 120(2): 275-80, 2007 Aug.
Article in English | MEDLINE | ID: mdl-17671052

ABSTRACT

OBJECTIVES: Case presentation and teaching performed at the bedside are declining. Patients' preference between bedside case presentation and conference-room case presentation is divergent in the literature. Residents seem to prefer the conference room. The objective of this study was to ascertain whether there was a difference of satisfaction and comfort between bedside case presentation and conference-room case presentation for the parents of patients hospitalized in the PICU and for the residents in training in the PICU. METHODS: Every child hospitalized in the PICU who had 2 consecutive morning rounds, performed in the presence of the same resident, attending pediatrician, and parent, was eligible for the study. The study began with the first patient's case presentation after admission in the PICU. Randomization was on the first case presentation: bedside or conference room. On the second day, the other type of case presentation was performed. After each round, the parents and the resident filled out a questionnaire. RESULTS: Twenty-seven parents of 22 patients answered both questionnaires, and 21 questionnaires were answered by residents. Parents' satisfaction was significantly higher during bedside case presentation (96 vs 92, answers reported on a 100-mm linear scale), they preferred bedside case presentation (95 vs 15), and they were more comfortable attending bedside teaching (89 vs 19). There was no difference in the residents' satisfaction nor in their comfort giving the actual case presentation. Residents, on the other hand, were significantly more comfortable asking questions (84 vs 69) and being asked questions (85 vs 67) during conference-room case presentation. A total of 81% of the parents wished that the next case presentation would take place at the bedside. CONCLUSIONS: This study demonstrates the feasibility of a clinical case presentation performed at the bedside in the PICU context that seems to satisfy parents without causing too much discomfort to residents. Thus, bedside case presentation could be a very good teaching strategy in university hospitals.


Subject(s)
Critical Care/methods , Intensive Care Units, Pediatric , Point-of-Care Systems , Teaching/methods , Adult , Child , Child, Preschool , Female , Humans , Infant , Infant, Newborn , Internship and Residency/methods , Male , Middle Aged , Parents/education
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