ABSTRACT
El mioepitelioma de glándula salivar es una neoplasia benigna poco frecuente, que afectaprincipalmente a la parótida (40 %) y que muestra exclusivamente diferenciación mioepitelial.Histológicamente, exhibe variables patrones arquitecturales y diferentes tipos celulares, quepueden ser dominantes o entremezclarse en diferentes proporciones, lo que condiciona unamarcada variabilidad morfológica en el material obtenido por PAAF y con frecuencia su incorrectainterpretación diagnóstica. Aportamos un caso de mioepitelioma parotídeo, diagnosticadoinicialmente como maligno en la PAAF, con estudio histológico e inmunohistoquímico
Salivary gland myoepithelioma is a benign rare neoplasm whose main location is the parotidgland (40 %) and displays an exclusive myoepithelial differentation. Histologically it shows severaland variable architectural patterns and cellular types that can be dominant or mixed in diverseproportions. This leads to a marked morphological variability in the material obtained by FNABand not unfrequently to a wrong diagnostic interpretation.We report the case of a parotid lump, initially diagnosed as a malignant neoplasm by FNAB.Later, the tumor ,was correctly diagnosed as myoepithelioma after histological and inmunohistochemicalexamination
Subject(s)
Male , Adult , Humans , Myoepithelioma/pathology , Parotid Neoplasms/pathology , Salivary Glands/pathology , Diagnosis, DifferentialABSTRACT
El mioepitelioma de glándula salivar es una neoplasia benigna poco frecuente, que afecta principalmente a la parótida (40 %) y que muestra exclusivamente diferenciación mioepitelial. Histológicamente, exhibe variables patrones arquitecturales y diferentes tipos celulares, que pueden ser dominantes o entremezclarse en diferentes proporciones, lo que condiciona una marcada variabilidad morfológica en el material obtenido por PAAF y con frecuencia su incorrecta interpretación diagnóstica. Aportamos un caso de mioepitelioma parotídeo, diagnosticado inicialmente como maligno en la PAAF, con estudio histológico e inmunohistoquímico
Salivary gland myoepithelioma is a benign rare neoplasm whose main location is the parotid gland (40 %) and displays an exclusive myoepithelial differentation. Histologically it shows several and variable architectural patterns and cellular types that can be dominant or mixed in diverse proportions. This leads to a marked morphological variability in the material obtained by FNAB and not unfrequently to a wrong diagnostic interpretation. We report the case of a parotid lump, initially diagnosed as a malignant neoplasm by FNAB. Later, the tumor ,was correctly diagnosed as myoepithelioma after histological and inmunohistochemical examination
Subject(s)
Male , Adult , Humans , Myoepithelioma/diagnosis , Myoepithelioma/pathology , Myoepithelioma/ultrastructure , Immunohistochemistry/methods , Cytodiagnosis/methods , Parotid Neoplasms/diagnosis , Neoplasms, Basal Cell/complications , Neoplasms, Basal Cell/diagnosis , Neoplasms, Basal Cell/pathology , Parotid Gland/anatomy & histology , Parotid Gland/cytology , Parotid Gland/pathology , Saliva/cytology , Microscopy/methods , Diagnosis, DifferentialABSTRACT
An unusual case of synchronous gastric carcinomas occurred in a 28-year-old man with a family history of gastric disease. Two tumor foci were identified: a well-differentiated advanced carcinoma with the phenotypic properties of complete intestinal metaplasia and an early intestinal-type carcinoma. Histochemical and immunohistochemical stains to demonstrate complete intestinal metaplasia, ie, Alcian blue pH 2.5/periodic acid-Schiff, high iron diamine/Alcian blue pH 2.5, CD10, and MUC2, were all positive in the advanced adenocarcinoma. Of all markers used, only high iron diamine/Alcian blue pH 2.5 and Alcian blue pH 0.5 were positive in the early carcinoma. In these cases, mistakes frequently are made during examination of endoscopic biopsies. Fortunately, the advanced adenocarcinoma was low grade (the patient has shown no signs of disease at 6 years postsurgery). Histopathologic, histochemical, and immunohistochemical findings suggest that an extensive substrate of complete intestinal metaplasia (corpus) and of complete and incomplete intestinal metaplasia (antrum) can be associated with two independent tumors with different phenotypes.
Subject(s)
Adenocarcinoma/diagnosis , Carcinoma/diagnosis , Intestinal Neoplasms/diagnosis , Intestines/pathology , Stomach Neoplasms/diagnosis , Adenocarcinoma/complications , Adenocarcinoma/pathology , Adult , Carcinoma/complications , Carcinoma/pathology , Histocytochemistry , Humans , Immunohistochemistry , Intestinal Neoplasms/complications , Intestinal Neoplasms/pathology , Male , Metaplasia , Phenotype , Stomach Neoplasms/complications , Stomach Neoplasms/pathologyABSTRACT
No disponible
