Subject(s)
Angina, Unstable/diagnosis , Chest Pain/diagnosis , Creatine Kinase/blood , Electrocardiography/methods , Myocardial Infarction/diagnosis , Troponin I/analysis , Adult , Aged , Angina, Unstable/epidemiology , Biomarkers/analysis , Chest Pain/epidemiology , Cohort Studies , Confidence Intervals , Diagnosis, Differential , Emergency Service, Hospital , Evidence-Based Medicine , Female , Humans , Incidence , Male , Middle Aged , Monitoring, Physiologic/methods , Myocardial Infarction/epidemiology , Odds Ratio , Risk Assessment , Risk Factors , Sensitivity and Specificity , Time Factors , United Kingdom/epidemiologyABSTRACT
BACKGROUND: Although urinary incontinence (UI) is a common and costly problem, its prevalence and severity in ambulatory patients is not well established. The main objectives of this study were to define the prevalence and severity of urinary incontinence in adult men and women who came to a primary care office for health care, to determine if these patients had ever told a health care provider about this problem, and to determine if they would be interested in treatment if it were available and effective. METHODS: Men and women aged 20 years and over who came to family physicians' offices seeking health care for any reason during an 11-week period were the subjects of a survey by an anonymous questionnaire. Five family practice offices in UPRNet (the Upper Peninsula Research Network), a research network in Michigan, participated. We defined "current urinary incontinence" as any degree of incontinence in the past 12 months. RESULTS: Of the 2830 study participants, 33% had current urinary incontinence (95% confidence interval [CI] 31% to 35%). Incontinence was experienced by 11% of the men and 43% of the women. Urinary incontinence constituting a social or hygienic problem was reported by 5% of the men and 23% of the women (17% overall). Of those with current UI, 72% had not told a health care provider. Of the patients who had not told a physician, 37% said they would seek care if they knew tests and effective treatment were available. CONCLUSIONS: Urinary incontinence is a common problem among those seen in primary care settings, and its presence is often not known to the health care provider.
Subject(s)
Urinary Incontinence/epidemiology , Adult , Aged , Family Practice , Female , Humans , Male , Michigan/epidemiology , Middle Aged , PrevalenceABSTRACT
The effects of the photosystem II herbicides diuron (3-(3,4-dichlorophenyl)-1,1-dimethylurea) and atrazine (2-chloro-4-ethylamino-6-isopropylamino-s-triazine) on the photosynthetic membranes of a cyanobacterium, Aphanocapsa 6308, were compared to the effects on a higher plant, Spinacia oleracea. The inhibition of photosystem II electron transport by these herbicides was investigated by measuring the photoreduction of the dye 2,6-dichlorophenol-indophenol spectrophotometrically using isolated membranes. The concentration of herbicide that caused 50% inhibition of electron transport (I(50) value) in Aphanocapsa membranes for diuron was 6.8 x 10(-9) molar and the I(50) value for atrazine was 8.8 x 10(-8) molar. (14)C-labeled diuron and atrazine were used to investigate herbicide binding with calculated binding constants (K) being 8.2 x 10(-8) molar for atrazine and 1.7 x 10(-7) molar for diuron. Competitive binding studies carried out on Aphanocapsa membranes using radiolabeled [(14)C]atrazine and unlabeled diuron revealed that diuron competed with atrazine for the herbicide-binding site. Experiments involving the photoaffinity label [(14)C]azidoatrazine (2-azido-4-ethylamino-6-isopropylamino-2-triazine) and autoradiography of polyacrylamide gels indicated that the herbicide atrazine binds to a 32-kilodalton protein in Aphanocapsa 6308 cell extracts.
