1.
Nursing
; 24(3): 66-7, 1994 Mar.
Article
in English
| MEDLINE
| ID: mdl-8127497
2.
J Med Chem
; 36(15): 2059-65, 1993 Jul 23.
Article
in English
| MEDLINE
| ID: mdl-8340910
ABSTRACT
The enantiomers of 6,7,8,9-tetrahydro-N,N-di-n-propyl-3H-benz[e]indol-8- amine (S-(-)-2b and R-(+)-2b) and their corresponding 1-formyl analogs (S-(-)-6 and R-(+)-6) were prepared and evaluated pharmacologically for serotonergic and dopaminergic activity. The introduction of a formyl group in the 1-position shifted the pharmacological profile of 2b from a mixed D2/5-HT1A agonists to a selective 5-HT1A agonist (6). The enantiomers of 6 were agonists with full intrinsic activity and had an affinity comparable to that of 8-hydroxy-2-(di-n-propylamino)tetrahydronaphthalene (8-OH-DPAT). In contrast to 8-OH-DPAT, the enantiomers of compound 6 were found to have good oral availability.
Subject(s)
Indoles/chemical synthesis , Serotonin Receptor Agonists/chemical synthesis , 8-Hydroxy-2-(di-n-propylamino)tetralin/pharmacology , Administration, Oral , Animals , Behavior, Animal/drug effects , Biological Availability , Indoles/pharmacokinetics , Indoles/pharmacology , Male , Rats , Rats, Sprague-Dawley , Serotonin Receptor Agonists/pharmacokinetics , Serotonin Receptor Agonists/pharmacology , Stereoisomerism , Structure-Activity Relationship
3.
Nursing
; 12(11): 129-36, 1982 Nov.
Article
in English
| MEDLINE
| ID: mdl-6924090
Subject(s)
Nursing Care/standards , Adult , Educational Measurement , Female , Humans , Male , Problem Solving
4.
Nursing
; 12(4): 161-9, 1982 Apr.
Article
in English
| MEDLINE
| ID: mdl-6917945