ABSTRACT
BACKGROUND: Barthel Index (BI) measures functional status. Our aim was to analyze if BI and other factors not included in Pneumonia Severity Index (PSI) predict mortality in general population with community acquired pneumonia (CAP). METHODS: Prospective observational study including all patients with CAP diagnosed in 2006. Endpoint of study: 30-day mortality. Variables not included in PSI as BI were analyzed. Strength of association was determined by odds ratio (OR) with 95% confidence interval. RESULTS: 550 patients, mean age of 60.3 ± 20.8, were included. 32 were lost during follow-up and 518 patients were finally analyzed. 44 (8.5%) patients died in the first 30 days after CAP diagnosis. In bivariate analysis, mortality was significantly more frequent in patients with PSI ≥ IV (19.2% vs 1.9%), BI≤80 points (23.9% vs 2.9%), multilobar infiltrate (20% vs 6%), diabetes mellitus (14.9% vs 6.5%), influenza vaccination (11.9% vs 6.6%) and pneumococcal vaccination (16.7% vs 6%). In multivariate analysis, mortality independently associated factors were: BI ≤80, OR: 3.9(CI95% 1.4-10.5; p < 0.001); PSI ≥ IV OR: 3.9(1.2-12.7; p < 0.05); and multilobar infiltrate OR: 2.9(1.1-7.3; p = 0.05). CONCLUSION: A BI score ≤80 is associated with a higher mortality in patients with CAP independently of the PSI. BI can be a useful tool to predict CAP mortality in general population.
Subject(s)
Community-Acquired Infections/mortality , Community-Acquired Infections/pathology , Pneumonia/mortality , Pneumonia/pathology , Severity of Illness Index , Adolescent , Adult , Aged , Aged, 80 and over , Female , Humans , Male , Middle Aged , Prognosis , Prospective Studies , Young AdultSubject(s)
Community-Acquired Infections/therapy , Pneumonia/therapy , Adult , Aged , Community-Acquired Infections/mortality , Comorbidity , Consensus Development Conferences as Topic , Decision Making , Emergency Service, Hospital , Family Practice , Humans , Patient Admission/standards , Pneumonia/mortality , Population Dynamics , Prognosis , Severity of Illness Index , Societies, Medical , Spain/epidemiologyABSTRACT
The efficacy and safety of levosimendan administration in patients with acute heart failure admitted to intensive care units has been well established. However, no information is available on the drug's beneficial effects in emergency departments. We studied 40 patients with acute heart failure who showed no or only partial improvement after conventional treatment and who received levosimendan during the period 2005-2006. The patients' mean age was 76 (9) years. The most common etiology was ischemic heart disease, and 85% of patients were in New York Heart Association (NYHA) class III or IV. The clinical response was favorable in 82% of patients, while adverse effects occurred in 18%. Some 70% were admitted to the emergency department short-stay unit. These findings indicate that levosimendan can be used safely and effectively in hospital emergency departments.
Subject(s)
Cardiotonic Agents/therapeutic use , Heart Failure/drug therapy , Hydrazones/therapeutic use , Pyridazines/therapeutic use , Acute Disease , Aged , Emergency Service, Hospital , Emergency Treatment , Female , Humans , Male , Prospective Studies , SimendanABSTRACT
La eficacia y la seguridad de la administración de levosimendán en las unidades de cuidados intensivos en pacientes con insuficiencia cardiaca aguda está bien establecida, pero no hay pruebas científicas de sus efectos favorables en los servicios de urgencias (SUH). Hemos estudiado a 40 pacientes con insuficiencia cardiaca aguda con ausencia de mejoría o mejoría parcial tras tratamiento convencional a los que se administró levosimendán entre 2005 y 2006. La media de edad fue de 76 ± 9 años. La cardiopatía isquémica fue la etiología más frecuente; el 85% de los pacientes se encontraba en estadio III-IV de la New York Heart Association. La respuesta clínica fue favorable en un 82% de los pacientes y sólo un 18% presentó efectos adversos. El 70% de los pacientes ingresó en la unidad de corta estancia dependiente del SUH. Los resultados obtenidos indican que levosimendán puede utilizarse de forma segura y eficaz en los SUH (AU)
The efficacy and safety of levosimendan administration in patients with acute heart failure admitted to intensive care units has been well established. However, no information is available on the drug's beneficial effects in emergency departments. We studied 40 patients with acute heart failure who showed no or only partial improvement after conventional treatment and who received levosimendan during the period 2005-2006. The patients' mean age was 76 (9) years. The most common etiology was ischemic heart disease, and 85% of patients were in New York Heart Association (NYHA) class III or IV. The clinical response was favorable in 82% of patients, while adverse effects occurred in 18%. Some 70% were admitted to the emergency department short-stay unit. These findings indicate that levosimendan can be used safely and effectively in hospital emergency departments (AU)
Subject(s)
Humans , Heart Failure/drug therapy , Receptors, Calcium-Sensing , Cardiotonic Agents/pharmacokinetics , Emergency Service, Hospital , Myocardial Ischemia/complications , Prospective StudiesSubject(s)
Anti-Bacterial Agents/administration & dosage , Ceftazidime/administration & dosage , Home Care Services, Hospital-Based/statistics & numerical data , Pseudomonas Infections/drug therapy , Aged , Aged, 80 and over , Aminoglycosides/administration & dosage , Aminoglycosides/therapeutic use , Anti-Bacterial Agents/economics , Anti-Bacterial Agents/therapeutic use , Ceftazidime/therapeutic use , Comorbidity , Drug Therapy, Combination , Female , Home Care Services, Hospital-Based/economics , Humans , Infusion Pumps/economics , Infusion Pumps/statistics & numerical data , Infusions, Intravenous/economics , Infusions, Intravenous/methods , Male , Middle Aged , Pseudomonas Infections/economics , SpainABSTRACT
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