Implicaciones anestésicas de la mastocitosis / No disponible

Las mastocitosis engloban un conjunto de enfermedades caracterizadas por un acúmulo de mastocitos en la piel, con o sin afectación de otros órganos o sistemas. La etiología de las mastocitosis es desconocida. Las formas cutáneas son generalmente propias de la infancia, y se pueden acompañar de manifestaciones clínicas generalizadas con o sin infiltración sistémica. La importancia anestésica de la enfermedad radica en que muchos de los fármacos empleados pueden ser causa de una liberación masiva de mediadores químicos mastocitarios. Presentamos una revisión de la implicaciones de las anestesia en el manejo de la mastocitosis (AU)

Mastocytosis encompass a group of diseases characterized by an accumulation of mast cells in the skin, with or without involvement of other organs or systems. The etiology of mastocytosis is unknown. Cutaneous forms are usually of childhood, and can be accompanied by widespread clinical manifestations with or without systemic infiltration. The importance of the disease anesthetic is that many of the drugs used can cause a massive release of mast cell chemical mediators. We present a review of the implications of anesthesia management will in mastocytosis (AU)

Involvement of the cytoskeleton in Junin virus multiplication.

The role of the cellular cytoskeleton in Junin virus (JV) infection was explored in two ways. Firstly, the action of inhibitors that affect individual cytoskeletal systems (microtubules or microfilaments) selectively was analysed. It was found that perturbations of microtubule or microfilament networks caused by colchicine, nocodazole, nifedipine, EGTA or DMSO strongly affected virion production and viral protein expression at non-cytotoxic concentrations. Secondly, the extent of association of viral proteins and infectious virus particles with the cytoskeletal fraction of monkey Vero cells was determined by using three non-ionic detergents, Triton X-100 (TX-100), NP-40 and octyl glucoside (OG). The cytoskeleton retained nearly 70% of the external JV envelope glycoprotein GP38 and about 40% of the JV nucleoprotein NP, according to TX-100 and OG insolubility results. Furthermore, 1% of the total cell-bound infectivity was detected in the detergent-insoluble fraction, suggesting that cytoskeletal components are involved in the initiation of the assembly and budding processes of JV particles at the plasma membrane.

[Comparison of seroconversion rates between well-nourished and malnourished children after measles immunization at nine months of age]. / Viragem sorológica após a vacinação contra o sarampo, realizada em crianças eutróficas e desnutridas, aos nove meses de idade.

The study was based on activities developed at Embu, SP, between October 1989 and June 1990. Its purpose was to study serological turning after child vaccination against measles at the age of nine months. Two groups were compared, both within the same age limits. Group number I included eutrophic children and group number II included undernourished children. Gomes criteria was used to evaluate the childrens nutritional state. Antibodies (AB) dosage was done through hemagglutination inhibition (HI) and ELISA. These two laboratory methods were also checked regarding its sensibility. Out of 130 children studied, 80 could be evaluated. From this total, 56 (70%) belonged to group I and 24 (30%) belonged to group II. When the ELISA method was used, a significantly higher seroconversion percentage (P < 0.05 or 5%) was found among children belonging to group II. This percentage was not detected when the HI method was used.