ABSTRACT
BACKGROUND: Atopic dermatitis (AD) is characterized by an impaired skin barrier, which can allow enhanced penetration of allergens. It is not clear whether AD influences the risk of developing contact allergy. OBJECTIVES: To examine the association between AD at preschool age and contact allergy at 16 years of age. METHODS: At 16 years of age, 2215 adolescents from the population-based cohort BAMSE were included. These adolescents had been followed with repeated questionnaires regarding AD throughout childhood, and contact allergy was assessed by skin patch test at 16 years. RESULTS: AD at preschool age was associated with contact allergy to at least one of the tested substances at 16 years of age among boys [adjusted odds ratio (OR) 1·51, 95% confidence interval (CI) 1·03-2·20] but not among girls (adjusted OR 0·77, 95% CI 0·54-1·10). AD at preschool age was not associated with contact allergy to nickel in either boys or girls. In contrast, AD at preschool age was associated with contact allergy to fragrance mix I (adjusted OR 3·10, 95% CI 1·66-5·80). This association was observed especially for AD at preschool age in combination with IgE sensitization to airborne or food allergens (adjusted OR 3·80, 95% CI 1·67-8·61). CONCLUSIONS: The results suggest that AD in early childhood may be associated with contact allergy to fragrances, but not to nickel, in adolescence.
Subject(s)
Dermatitis, Allergic Contact/epidemiology , Dermatitis, Atopic/epidemiology , Adolescent , Child , Child, Preschool , Dermatitis, Allergic Contact/diagnosis , Female , Follow-Up Studies , Humans , Infant , Male , Patch Tests , Risk Assessment , Risk Factors , Self Report/statistics & numerical data , Sex Factors , Sweden/epidemiologyABSTRACT
Seven females, six laboratory assistants, participated in the experimental part of the study. The level of muscular activity in different sitting work postures was recorded, using surface electrodes, as full-wave-rectified and low-pass filtered EMG, and normalised. The laboratory assistants also rated the degree of exertion in four different body regions during their ordinary microtome sectioning work, comparing the use of anterior chest support with the use of their usual chair with lumbar support. The use of anterior chest support reduced the muscular activity in the lumbar back muscles but increased it in the shoulder muscles. Perceived exertion in the neck, shoulders and thoracic back regions increased. Anterior chest support does not seem to solve the problem of neck- and-shoulder load-elicited pain during the work of preparing laboratory sections.
