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Allergy ; 79(3): 552-564, 2024 Mar.
Article in English | MEDLINE | ID: mdl-38013608

ABSTRACT

Proton pump inhibitors (PPIs) are invaluable therapeutic options in a variety of dyspeptic diseases. In addition to their well-known risk profile, PPI consumption is related to food and environmental allergies, dysbiosis, osteoporosis, as well as immediate and delayed hypersensitivity reactions (HSRs). The latter, although a rare event, around 1%-3%, due to the extraordinarily high rate of prescription and consumption of PPIs are related to a substantial risk. In this Position Paper, we provide clinicians with practical evidence-based recommendations for the diagnosis and management of HSRs to PPIs. Furthermore, the unmet needs proposed in the document aim to stimulate more in-depth investigations in the topic.


Subject(s)
Drug Hypersensitivity , Hypersensitivity, Immediate , Hypersensitivity , Humans , Proton Pump Inhibitors/adverse effects , Drug Hypersensitivity/diagnosis , Drug Hypersensitivity/etiology , Drug Hypersensitivity/therapy , Hypersensitivity, Immediate/diagnosis , Skin Tests
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