ABSTRACT
Nowadays, in Russia, diethyl ether is the most popular narcosis for rodent and particular rats. We had tested the new methods based on Zoletil 100 + XylaVet (15 mg/kg and 15-10-5 mg/kg) respectively. 6 conventional female rats were treated with this narcosis. The rats, early have narcotized by diethyl ether were investigated as control group. All of 6 treated with new narcosis animals died in early post-operative time. Interestingly enough, that organ toxicity, except neurologic toxicity, was not described in literature and manuals. We assume that this new narcosis is the cause of portal thromboses.
Subject(s)
Anesthesia, General/adverse effects , Anesthetics/adverse effects , Budd-Chiari Syndrome/chemically induced , Digestive System Surgical Procedures/adverse effects , Postoperative Complications/chemically induced , Tiletamine/adverse effects , Zolazepam/adverse effects , Anesthesia, General/methods , Anesthetics/pharmacology , Animals , Digestive System Surgical Procedures/methods , Drug Combinations , Female , Rats , Tiletamine/pharmacology , Zolazepam/pharmacologyABSTRACT
This study was performed to understand behavior and toxic liver defect in rats in the use of low-alcohol drinks (LAD) and energy drinks (ED). Young rats quickly become accustomed to the LAD, increased tolerance to alcohol. Rats were getting a habit, an intoxicating effect was faster than at the beginning of the LAD using. Were emerged diseases (pneumonia) that more characteristic for more mature animals, was expressed toxic liver defect. All these changes come faster and more pronounced in those animals that drank ED before that. It is necessary to mark that using of a LAD and ED leed to habit and necessity to increase doses of these beverages. Hierarchy of needs were changed, self-preservation instinct was virtually absent, reduced drinking water or food craving.
