ABSTRACT
Hypereosinophilia (HE) is rare but often secondary to a nonhematologic disease such as allergic disorders and parasitic infections. HE can also be associated with hematologic malignancies and be the result of a clonal proliferation or reactive to another hematologic condition. Association of HE with acute lymphoblastic leukemia (ALL) is rare in children. We reported a case of a teenager presented with HE secondary to B-ALL who experienced severe cardiac complications with severe absolute eosinophil count. We compared his clinical evolution with other published cases and we reported 2 mutations linked to B-ALL never described before in this context.
Subject(s)
Cardiomyopathies/pathology , Hypereosinophilic Syndrome/pathology , Lymphoma, B-Cell/pathology , Precursor Cell Lymphoblastic Leukemia-Lymphoma/pathology , Adolescent , Cardiomyopathies/etiology , Humans , Hypereosinophilic Syndrome/etiology , Lymphoma, B-Cell/complications , Male , Precursor Cell Lymphoblastic Leukemia-Lymphoma/complications , PrognosisABSTRACT
Teaching point: The mnemonic CRITOE is a must-know that describes the sequence of elbow ossification center appearance and stands for capitellum, radial head, internal epicondyle, trochlea, olecranon and external epicondyle.
