1.
J Org Chem
; 73(10): 3970-3, 2008 May 16.
Article
in English
| MEDLINE
| ID: mdl-18419160
ABSTRACT
The alkylation reactions of an amide enolate derived from a trifluoromethylated oxazolidine (Fox) chiral auxiliary occur with a complete diastereoselectivity and in good yields with various electrophiles. This reaction provides a versatile and straightforward strategy for the synthesis of beta(2)-amino acids and gamma-amino alcohols in enantiopure form.
Subject(s)
Amino Acids/chemical synthesis , Amino Alcohols/chemical synthesis , Oxazoles/chemistry , Amino Acids/chemistry , Amino Alcohols/chemistry , Molecular Conformation , Stereoisomerism
2.
Beilstein J Org Chem
; 1(1): 11, 2005 Oct 07.
Article
in English
| MEDLINE
| ID: mdl-16542022
ABSTRACT
The synthesis of gamma-functionalized cyclopentenones was carried out in a few steps, starting firstly with the preparation of nitroketonic intermediates 2, which were readily transformed into 1,4-diketones using the Nef conversion. The intramolecular cyclization of the gamma-diketones 3 in a basic medium, led to the functionalized cyclopentenones 4.