Subject(s)
Antiprotozoal Agents , Cardiomyopathy, Dilated , Leishmaniasis, Cutaneous , Organometallic Compounds , Humans , Meglumine Antimoniate/adverse effects , Cardiomyopathy, Dilated/chemically induced , Cardiomyopathy, Dilated/drug therapy , Meglumine/adverse effects , Leishmaniasis, Cutaneous/diagnosis , Leishmaniasis, Cutaneous/drug therapyABSTRACT
Chemotherapy extravasation is a rare but severe cutaneous complication associated with administration of intravenous chemotherapy. Extravasation causes serious disability and diminishes the quality of life in patients with cancer undergoing antineoplastic therapy. Treatment of chemotherapy extravasation is not standardized. We report a patient with paclitaxel extravasation who was successfully treated with corticosteroids.
Subject(s)
Antineoplastic Agents, Phytogenic , Paclitaxel , Humans , Paclitaxel/adverse effects , Antineoplastic Agents, Phytogenic/adverse effects , Quality of Life , Extravasation of Diagnostic and Therapeutic Materials , SkinABSTRACT
Tinea capitis (TC) is a common infectious disease throughout the world, mainly seen in children, but it can occur in adults. Even if mycological examination is essential to confirm the diagnosis, it has been proved that trichoscopy is a very effective useful tool in the screening of TC. Herein, we report two cases of adult TC with atypical clinical presentations causing a diagnostic delay of several years.
Subject(s)
Acute Generalized Exanthematous Pustulosis/pathology , Erythema/pathology , Spider Bites/pathology , Acute Generalized Exanthematous Pustulosis/diagnosis , Acute Generalized Exanthematous Pustulosis/etiology , Animals , Erythema/diagnosis , Erythema/etiology , Female , Humans , Middle Aged , Remission, Spontaneous , Skin/pathology , Spider Bites/complications , Spider Bites/diagnosis , Spiders/pathogenicity , Watchful WaitingABSTRACT
Bullous morphea is a rare variant of localized scleroderma characterized by occasional intermittent blisters. Lichen sclerosus is a chronic inflammatory disease. The coexistence of morphea and lichen sclerosus has been reported in different sites in the same patient and more rarely in the same lesion. We report the case of a 54-year-old woman with an atypical presentation of bullous morphea and some histological features of lichen sclerosus. She presented with a 5-year history of an ulcerated plaque, with a sclerotic and atrophic center and indurated budding margins, localized on the lumbar back. Initially the diagnosis of a squamous cell carcinoma was suggested. A skin biopsy confirmed the diagnosis of bullous morphea and showed some histological features of lichen sclerosus. Topical betamethasone and silicone gel ointment were prescribed leading to complete healing of the ulceration within five months. Our case is unusual because of the atypical clinical presentation, the histological aspect combining signs of bullous morphea and lichen sclerosus, and the favorable results with the use of local corticotherapy and silicone gel.
Subject(s)
Scleroderma, Localized/pathology , Silicone Gels/administration & dosage , Administration, Topical , Adrenal Cortex Hormones/administration & dosage , Female , Humans , Middle Aged , Scleroderma, Localized/drug therapyABSTRACT
BACKGROUND: Atopic dermatitis (AD) is a heterogeneous disease. Thus, it is difficult to set up standard diagnostic criteria that cover the entire spectrum of AD patients. Our objectives were to study the epidemiologic characteristics of AD in Tunisia and to evaluate five diagnostic criteria (Hanifin and Rajka, Williams, Taieb and Boralevi, REACH and ISAAC questionnaire). METHODS: This prospective case-control study was carried out in our Dermatology Department in Tunisia. The cases and controls were collected over a period of one year (January 3, 2017, to January 2, 2018). RESULTS: We collected 101 patients with AD and 101 controls. Patients and controls were comparable by age and gender. The mean age of patients was 9 years and 9 months with sex ratio 1.02. Children accounted for more than half of the patients (61.39%). The sensitivity and specificity of the criteria were, respectively: 90.1% and 90.1% for the Hanifin and Rajka criteria, 53.47% and 96.04% for the Williams criteria, 62.50% and 92.3% for the Taieb and Boralevi criteria, 41.58% and 92.08% for ISAAC questionnaire, 49.5% and 91.09% for REACH questionnaire. A new version of AD diagnostic criteria has been proposed. By applying these new criteria retrospectively to our patients, the sensitivity rises to 90.1%. CONCLUSION: The new version of AD criteria is a practical diagnostic tool compared to the Hanifin and Rajka criteria and seems to correct the problem of low sensitivity of the Williams criteria. Large validation studies are needed.
